A5052931233- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Bioactive Compounds and Antitumor Agents
- Protein Tyrosine Phosphatases
- Computational Drug Discovery Methods
- Microbial Natural Products and Biosynthesis
- Long-Term Effects of COVID-19
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Natural product bioactivities and synthesis
- Diabetes Treatment and Management
- Chemical synthesis and alkaloids
- Natural Antidiabetic Agents Studies
- Cancer-related Molecular Pathways
- Vitamin C and Antioxidants Research
- Natural Products and Biological Research
- Pituitary Gland Disorders and Treatments
- Pregnancy and Medication Impact
- Phytochemistry Medicinal Plant Applications
- Environmental and Cultural Studies in Latin America and Beyond
- Quinazolinone synthesis and applications
Universidad La Salle
2015-2024
Universidad La Salle
2015-2021
Universidad Nacional Autónoma de México
2007-2019
Multidisciplinary Digital Publishing Institute (Switzerland)
2019
The development of severe COVID-19 is related to the preexistence comorbidities and an inadequate nutritional status. latter a critical factor for infection progression disease. Notably, optimal nutrition impacts immune system function, as malnutrition high cytokine levels in late phase disease, correlating with poor prognosis. In this sense, omega-3 fatty acids (O3FAs) have anti-inflammatory properties that may reduce morbidity mortality from infection. O3FAs are linked better prognosis...
An increasing occurrence of resistance in insect pests and high mammal toxicity exhibited by common pesticides increase the need for new alternative molecules. Among these alternatives, bioinsecticides are considered to be environmentally friendly safer than synthetic insecticides. Particularly, plant extracts have shown great potential laboratory conditions. However, lack studies that confirm their mechanisms action diminishes applications on a large scale. Previously, we reported growth...
SARS-CoV-2 infects host cells by interacting its spike protein with surface angiotensin-converting enzyme 2 (ACE2) receptors, expressed in lung and other cell types. Although several risk factors could explain why some countries have lower incidence fatality rates than others, environmental such as diet should be considered. It has been described that high polyunsaturated fatty acid (PUFA) intake a number of COVID-19 victims higher rate recovery from the disease. Moreover, it was found...
Panama has an extensive mangrove area and it is one of the countries with highest biodiversity in America. Mangroves are widely used traditional medicine, nevertheless, there very few studies that validates their medicinal properties Given urgent need for therapeutic options to treat several diseases public health importance, ecosystem could be interesting source new bioactive molecules. This study was designed evaluate potential Pelliciera rhizophorae as a compounds. The present...
The first semisynthesis and biological profiling of the new abietane diterpenoid (+)-liquiditerpenoic acid A (abietopinoic acid) (7) along with several analogues are reported. compounds were obtained from readily available methyl dehydroabietate (8), which was derived (−)-abietic (1). Biological comparison conducted according to different functional groups, leading some basic structure–activity relationships (SAR). In particular, ferruginol sugiol 7 10–16 characterized by presence an...
The design of multitarget drugs is an essential area research in Medicinal Chemistry since they have been proposed as potential therapeutics for the management complex diseases. However, defining a drug not easy task. In this work, we propose vector analysis measuring and "multitargeticity." We developed terms, such order force ligand, to finally reach two parameters: indexes 1 2. combination these allows discrimination drugs. Several training sets were constructed test usefulness indexes:...
Mangroves plants and their endophytes represent a natural source of novel bioactive compounds. In our ongoing research on mangrove from the Panamanian Pacific Coast, we have identified several endophytic fungi. From these organisms, an isolate belonging to genus
Metabolic syndrome (MetS) is a complex disease that includes metabolic and physiological alterations in various organs such as the heart, pancreas, liver, brain. Reports indicate blackberry consumption, maqui berry, has beneficial effect on chronic diseases cardiovascular disease, obesity, diabetes. In present study, vivo silico studies have been performed to evaluate molecular mechanisms implied improve parameters of MetS. Fourteen-day administration berry reduces weight gain, blood fasting...
Infection from multidrug resistant bacteria has become a growing health concern worldwide, increasing the need for developing new antibacterial agents. Among strategies that have been studied, biofilm inhibitors acquired relevance as potential source of drugs could act complement current and therapies. Based on structure 2-alkyl-3-hydroxy-4-quinolone N-acylhomoserine lactone, molecules mediators quorum sensing formation in Pseudomonas aeruginosa, we designed, prepared, evaluated inhibition...
Metabolic syndrome (MetS) contributes to the spread of cardiovascular diseases, diabetes mellitus type 2, and neurodegenerative diseases. Evaluation sex- hormone-dependent changes in body weight, blood pressure, lipids, oxidative stress markers, alterations different types memory Sprague-Dawley rats fed with a high fat fructose (HFHF) diet were evaluated. After 12 weeks feeding male female HFHF, weight gain, increase generation dyslipidemia compared animals chow observed. Regarding memory,...
Metabolic syndrome (MetS) is a complex disease that affects almost quarter of the world’s adult population. In MetS, diabetes, obesity, hyperglycemia, high cholesterol, and blood pressure are most common disorders. Polypharmacy used strategy for managing conditions related to but it has drawbacks such as low medication adherence. Multitarget ligands have been proposed an interesting approach developing drugs treat diseases. However, suitable preclinical models allow their evaluation in...
p21-Activated kinase-1 (Pak1) is frequently overexpressed and/or amplified in human breast cancer and necessary for transformation of mammary epithelial cells. Here, we show that Pak1 interacts with phosphorylates the Calcium/Calmodulin-dependent Protein Kinase II (CaMKII), pharmacological inhibition or depletion leads to diminished activity CaMKII. We found a strong correlation between CaMKII expression samples, combined small-molecule inhibitors was synergistic induced apoptosis more...
During pregnancy, there is a state of immune tolerance that predisposes them to viral infection, causing maternal-fetal vulnerability the adverse effects COVID-19. Bacterial coinfections significantly increase mortality rate for However, it known all drugs, including antibiotics, will enter fetal circulation in variable degree despite role placenta as protective barrier and can cause teratogenesis or other malformations depending on timing exposure drug. Also, important consider impact...
Metabolic syndrome is a set of risk factors that consist abdominal obesity, arterial hypertension, alterations in the lipid profile, and hyperglycemia. The current therapeutic strategy includes polypharmacy, using three or more drugs to control each component. However, this approach has drawbacks could lead failure. Multitarget are molecules with ability act on different targets simultaneously an attractive alternative for treating complex diseases such as metabolic syndrome. Previously, we...