A5021551521- Hearing Loss and Rehabilitation
- Neuroscience and Music Perception
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Optical Imaging and Spectroscopy Techniques
- Noise Effects and Management
- Multisensory perception and integration
- Craniofacial Disorders and Treatments
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Orthodontics and Dentofacial Orthopedics
- Visual perception and processing mechanisms
- Speech and Audio Processing
- Cleft Lip and Palate Research
- Advanced Image Processing Techniques
- Image Processing Techniques and Applications
- Obstructive Sleep Apnea Research
- Cardiovascular and Diving-Related Complications
- Hearing, Cochlea, Tinnitus, Genetics
- Music Technology and Sound Studies
- Neuroscience of respiration and sleep
- Blind Source Separation Techniques
- Music and Audio Processing
- Photoacoustic and Ultrasonic Imaging
Capital Medical University
2019-2025
Beijing Tongren Hospital
2022-2025
Abstract Healthy aging leads to complex changes in the functional network of speech processing a noisy environment. The dual‐route neural architecture has been applied study processing. Although evidence suggests that senescent increases activity brain regions across dorsal and ventral stream offset reduced periphery, regulatory mechanism networks underlying such compensation remains largely unknown. Here, by utilizing near‐infrared spectroscopy (fNIRS), we investigated compensatory...
Abstract Deconvolution is the most commonly used image processing method in optical imaging systems to remove blur caused by point‐spread function (PSF). While this has been successful deblurring, it suffers from several disadvantages, such as slow time due multiple iterations required deblur and suboptimal cases where experimental operator chosen represent PSF not optimal. In paper, we present a deep‐learning‐based deblurring that fast applicable microscopic systems. We tested robustness of...
Abstract Our ability to localize low‐frequency sounds relies on interaural time differences (ITD), a sensitivity that is fundamental our pinpoint sound sources in azimuth and segregate competing across wide range of situations. However, the neural representation ITD has not been well characterized. This study aimed elucidate distinctions evoked cortical potentials global functional connectivity during unattended processing localization horizontal plane, by recording analyzing auditory...
Abstract Speech comprehension in noise depends on complex interactions between peripheral sensory and central cognitive systems. Despite having normal hearing, older adults show difficulties speech comprehension. It remains unclear whether the brain’s neural responses could indicate aging. The current study examined individual brain activation during perception different listening environments predict age. We applied functional near-infrared spectroscopy to 93 normal-hearing human (20 70...
Background Patients with severe profound hearing loss could benefit from cochlear implantation (CI). However, the neural mechanism of such is still unclear. Therefore, we analyzed electroencephalogram (EEG) and behavioral indicators auditory function remodeling in patients CI. Both were sampled at multiple time points after (1, 90, 180 days). Methods First, speech perception ability was evaluated recording a list Chinese words sentences 15 healthy controls (HC group) 10 CI (CI group). EEG...
Patients with age-related hearing loss (ARHL) often struggle tracking and locating sound sources, but the neural signature associated these impairments remains unclear. Using a passive listening task stimuli from five different horizontal directions in functional magnetic resonance imaging, we defined regions of interest (ROIs) auditory "where" pathway based on data previous literatures young normal listeners (n = 20). Then, investigated associations demographic, cognitive, behavioral...
In this study, we investigated brain morphological changes in adults with non-syndromic cleft lip and palate (NSCLP) after articulation rehabilitation (AR). High-resolution T1 weighted magnetic resonance imaging data were analyzed from 45 NSCLP palatoplasty: 24 subjects assessed before AR (bNSCLP) 21 (aNSCLP). addition, there age sex matched controls. Intergroup differences of grey matter volume evaluated as a comprehensive measure the cortex; cortical thickness complexity (gyrification...
Previous studies reported that auditory cortices (AC) were mostly activated by sounds coming from the contralateral hemifield. As a result, sound locations could be encoded integrating opposite activations both sides of AC ("opponent hemifield coding"). However, human "where" pathway also includes series parietal and prefrontal regions. It was unknown how represented in those high-level regions during passive listening. Here, we investigated neural representation voxel-level tuning analysis,...
Cochlear implants (CIs) allow patients with severe to profound hearing loss gain or regain their sense of hearing. However, the objective assessment auditory rehabilitation in CI users remains a challenge. In particular, utility phase-amplitude coupling (PAC) for evaluating postoperative unknown. present study, we conducted an oddball paradigm stimuli varying sample speech syllables and collected electroencephalography (EEG) signals 10 at time implant was activated 180 days after activation....
Abstract Understanding speech-in-noise is a significant challenge for individuals with age-related hearing loss (ARHL). Evidence suggests that increased activity in the frontal cortex compensates impaired speech perception healthy aging older adults. However, whether adults ARHL still show preserved compensatory function and specific neural regulatory mechanisms underlying such compensation remains largely unclear. Here, by utilizing synchronized EEG-fNIRS test, we investigated oscillatory...
Abstract The onset of hearing loss can lead to altered brain structure and functions. However, restoration may also result in distinct cortical reorganization. A differential pattern functional remodeling was observed between post- prelingual cochlear implant users, but it remains unclear how these speech processing networks are reorganized after implantation. To explore the impact language acquisition on perception we conducted assessments activation, connectivity, graph theory-based...
Aging and language background have been shown to affect pitch information encoding at the subcortical level. To study individual compounded effects on encoding, Frequency Following Responses were recorded from subjects across various ages backgrounds. Differences found in strength accuracy among groups, indicating that experience aging magnitude of ability Moreover, stronger seen phase-locking native speaker while appears more impact tracking older adult groups.
Abstract Our ability to localize low-frequency sounds relies on interaural time differences (ITD), the sensitivity which underlies our sound sources in azimuth and segregate competing across a wide range of situations. However, cortical representation ITD has not been well characterized. To investigate evoked potentials global functional connectivity during unattended processing localization horizontal plane, auditory mismatch negativity (MMN) was recorded analyzed adults using...