A5088361178- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Fetal and Pediatric Neurological Disorders
- Congenital Anomalies and Fetal Surgery
- Cancer-related molecular mechanisms research
- Shoulder Injury and Treatment
- RNA modifications and cancer
- Tendon Structure and Treatment
- Periodontal Regeneration and Treatments
- Congenital Ear and Nasal Anomalies
- EEG and Brain-Computer Interfaces
- Orthopedic Surgery and Rehabilitation
- Language Development and Disorders
- Tumors and Oncological Cases
- Orthodontics and Dentofacial Orthopedics
- Hedgehog Signaling Pathway Studies
- Fractal and DNA sequence analysis
- Fusion and Plasma Physics Studies
- Seismic Imaging and Inversion Techniques
- Milk Quality and Mastitis in Dairy Cows
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Structural Response to Dynamic Loads
- Analytical chemistry methods development
- Cancer-related Molecular Pathways
- Hydrocarbon exploration and reservoir analysis
Capital Medical University
2015-2024
Tianjin Stomatological Hospital
2018-2021
Beijing Obstetrics and Gynecology Hospital
2020-2021
October 6 University
2021
Beijing Hospital
2017
Dalian University of Technology
2015
Sinopec (China)
2014
Yangzhou University
2013
Xuzhou Medical College
2013
Shanxi Medical University
2011
Dispersive liquid-liquid microextraction is a new sample pretreatment technology based on traditional liquid extraction. In this paper, the application of low-toxicity extractants such as low-density extractants, auxiliary stripping agents and ionic liquids in extraction modes solvent de-emulsification, suspension extractant curing, extraction, back liquid-dispersion microextraction, are summarized. addition, synergism technique with other preparation techniques, solid-phase dispersive solid...
The main of the present study was to investigate role insulin-like growth factor 2 mRNA-binding protein (IGF2BP2) in oral squamous cell carcinoma (OSCC) with overarching providing new biomarkers or potential therapeutic targets for OSCC.We combined datasets downloaded from Gene Expression Omnibus (GEO), Cancer Genome Atlas (TCGA), and samples collected clinic evaluate expression IGF2BP2 OSCC. survival analysis respectively performed based on TCGA, GEO, clinical samples. Correlations between...
Abstract A crucial component of the musculoskeletal system, tendon is one most commonly injured tissues in body. In severe cases, ruptured leads to permanent dysfunction. Although many efforts have been devoted seeking a safe and efficient treatment for enhancing healing, currently existing treatments not yet achieved major clinical improvement. Here, an injectable granular hyaluronic acid (gHA)‐hydrogel engineered deliver fibromodulin (FMOD)—a bioactive extracellular matrix (ECM) that...
Abstract Facial nerves are frequently crushed or cut during facial surgery. In this study, the feasibility of repairing in rabbits after crush off injury was evaluated using collagen conduits with A collagen‐binding domain (CBD)‐human basic fibroblast growth factor (bFGF). total 39 six‐month‐old New Zealand White were randomly divided into four groups nine rabbits, and bilateral injuries made on each animal's face. Three classified as healthy control. The then either untreated wrapped a...
Ankyloblepharon–ectodermal defects–cleft lip/palate (AEC) syndrome, also known as Hay–Wells is an autosomal genetic disease with the main features of ankyloblepharon filiforme adnatum, ectodermal defects, and cleft lip/palate. The authors report a patient 17 months old girl AEC syndrome having ankyloblepharon, palate, ectrodactyly some associated features. Etiology, clinical features, differential diagnosis, treatment have been elaborated in this report.
An extremely rare patient of congenital midline sinus the upper lip in a 2-year-old boy is presented. The was located on philtrum just below base columella. Surgical removal performed via an extra- and inraoral approach. Histopathological examination resected revealed it to be lined by keratinized stratified squamous epithelium with sebaceous glands hair follicles. Three postulates can account for formation lip: fusion theory, merging invagination theory. However, etiology this abnormality...
In this study, we investigated brain morphological changes in adults with non-syndromic cleft lip and palate (NSCLP) after articulation rehabilitation (AR). High-resolution T1 weighted magnetic resonance imaging data were analyzed from 45 NSCLP palatoplasty: 24 subjects assessed before AR (bNSCLP) 21 (aNSCLP). addition, there age sex matched controls. Intergroup differences of grey matter volume evaluated as a comprehensive measure the cortex; cortical thickness complexity (gyrification...
This study aimed to explore brain activation in patients with cleft lip and palate (CLP) using a Chinese character subvocalization task, which the stimuli were selected from clinical articulation evaluation test. CLP is congenital disability. Individuals usually have disorder caused by abnormal structure. Previous studies showed that primary somatosensory motor areas had significant difference CLP. However, whether was restored normal level after palatoplasty speech rehabilitation not clear....
Human alveolar bone-derived mesenchymal stem cells (hABMSCs) are promising candidates for bone therapies, which have the capacity to differentiate into osteoblasts. Recently, secretion of inducible cytokines and growth factors from (MSCs) has been discovered, we also reported osteogenic effects cell physical stimulation. In this study, investigated hABMSCs-conditioned media (B-CSM) on differentiation hABMSCs in vitro. Furthermore, analyzed B-CSM by proteomics array identify facilitate...
Non-syndromic cleft lip with or without palate (NSCL/P) is a common craniofacial birth defect. Growing evidence has demonstrated the competing endogenous RNA (ceRNA) hypothesis played role in pathogenesis of NSCL/P. Here, we identified important lncRNAs NSCL/P and constructed ceRNA regulatory network to predict their underlying functional mechanism.Total isolated from peripheral blood samples were analyzed by Human Clariom D Affymetrix platform differentially expressed genes (DEGs)...
The development of an expert consensus based on specific domestic situations will provide practical guidance to the efforts aiming at improving cleft care in China. team approach twenty-one centers were pooled together, covering pre-surgical orthopedics, primary surgical repair, orthodontic treatment, alveolar bone graft, secondary deformity correction, palatal fistulae diagnosis and treatment velopharyngeal incompetence, speech therapy, otitis media management, skeletal correction....
Nonsyndromic cleft lip with or without palate (NSCL/P) represents a complex condition caused by genetic and environmental factors. The aim of this study was to investigate the relationship between EPHA3 polymorphisms NSCL/P.To five single nucleotide (SNPs) NSCL/P, we selected 180 affected patients 167 normal controls from Chinese Han Population. SNPs (rs7650466, rs1398197, rs17801309, rs1054750, rs7632427) were genotyped using SNaPshot technique; bioinformatic analyses performed determine if...
Speech therapy has been widely used as an essential for compensatory articulation errors in nonsyndromic cleft lip and palate patients. We sought to identify potential biomarkers of children after speech rehabilitation based on resting-state fMRI graph theory techniques. scanned 28 typically developing a 3T MRI scanner. Functional networks were constructed, their topological properties obtained assessing between-group differences (two-sample t-tests). Also, language clear degree scale scores...
Cleft lip and palate (CLP) is one of the most common craniofacial malformations. Overall, 40–80% CLP patients have varying degrees articulation problems after palatoplasty. Previous studies revealed abnormal articulation-related brain function in patients. However, association between disorders cortical structure development remains unclear. Twenty-six adolescents (aged 5–14 years; mean 8.88 female/male 8/18), twenty-three adults 18–35 23.35 6/17), thirty-seven healthy 5–16 9.89 5/16),...
Non-syndromic clefts of the lip and/or palate (NSCLP) is most common congenital anomaly in craniofacial region. NSCLP a highly gene-associated malformation. We speculate that pregnant women with fetuses (pregnancies NSCLP) may have specific brain changes during pregnancy. To explore characteristic function pregnancies NSCLP, we analyzed resting-state MRI (rs-MRI) data forty-two (21 and 21 normal fetuses) to compare intergroup differences (fractional) amplitude low frequency fluctuations...
In vitro evaluation of the effects plasminogen activator inhibitor-1 (PAI-1) transfected-conditioned media (P-CM) on differentiation human periodontal ligament stem cells (hPDLSCs) and periapical follicular (hPAFSCs).The hPDLSCs hPAFSCs received from impacted third molars were treated with P-CM viability, as well evaluated. Plasmids constructed according to standard techniques, all sequences validated by proper enzyme digestion sequencing. Chinese hamster ovarian (CHO) transfected...
Abstract Background Cleft lip and palate is one of the most common oral maxillofacial deformities associated with a variety functional disorders. speech disorder (CPSD) occurs frequently manifests series characteristic features, which are called cleft characteristics. Some scholars believe that children CPSD poor outcomes may also have weaknesses in input processing ability, but evidence still lacking so far. Aims (1) To explore whether output disorders defects abilities; (2) to correlation...
The cleft lip and palate (CLP) is one of the most common craniofacial malformations in humans. We collected functional magnetic resonance data 23 CLP patients before rehabilitation training (Bclp) after (Aclp), who were performing Chinese character pronunciation tasks, performed brain activation analysis to explore changes mechanism articulation disorder training. study found that Aclp group had significant motor cortex, Broca area, Wernicke area cerebellum. While Bclp weak cortex with a...
Abstract Previous research showed that pharynx in adult patients with unrepaired isolated cleft palate (UICP) significantly enlarged. However, the literature lacks studies juvenile patients. Thus, this study aimed to conduct a 3-dimensional evaluation of UICP using cone beam computed tomography. Cone tomography images 58 nonsyndromic and 60 noncleft controls aged from 4 13 years were acquired. Both divided into 3 groups according their ages. Image processing analyses performed Mimics ZWCAD....