A5022993204- Reconstructive Surgery and Microvascular Techniques
- Reconstructive Facial Surgery Techniques
- Wound Healing and Treatments
- melanin and skin pigmentation
- Facial Rejuvenation and Surgery Techniques
- Dermatologic Treatments and Research
- Surgical Sutures and Adhesives
- Urological Disorders and Treatments
- Surgical site infection prevention
- Nasal Surgery and Airway Studies
- Tissue Engineering and Regenerative Medicine
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Melanoma and MAPK Pathways
- Facial Nerve Paralysis Treatment and Research
- Skin Protection and Aging
- Urologic and reproductive health conditions
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- Trauma Management and Diagnosis
- Photoacoustic and Ultrasonic Imaging
- Botulinum Toxin and Related Neurological Disorders
- Female Genital Mutilation/Cutting Issues
Second Military Medical University
2016-2025
Changhai Hospital
2016-2025
Qingdao University
2018-2020
Qingdao Municipal Hospital
2018-2020
American College of Surgeons
2020
Creative Commons
2020
Wake Forest University
2020
Christie's
2020
Abstract Excessive scar formation caused by myofibroblast aggregations is of great clinical importance during skin wound healing. Studies have shown that mesenchymal stem cells (MSCs) can promote regeneration, but whether MSCs contribute to remains undefined. We found umbilical cord-derived (uMSCs) reduced and accumulation in a skin-defect mouse model. these functions were mainly dependent on uMSC-derived exosomes (uMSC-Exos) especially exosomal microRNAs. Through high-throughput RNA...
Modulating the surface properties of nanoparticles (NPs) is an important approach to accomplish immune escape, prolonged blood retention time, and enhance ability targeted drug delivery. The camouflage cancer cell membrane onto has been proved be ideal active targeting NPs. Herein, we isolated melanoma cells coat doxorubicin (DOX) indocyanine green (ICG)-loaded hollow copper sulfide NPs (ID-HCuSNP@B16F10) for photothermal therapy, photoacoustic imaging, chemotherapy. A remarkable in vitro...
Spalt-like transcription factor 4 (SALL4) plays a vital role in the progression of many human diseases. However, and mechanism SALL4 regulates keloid formation remain unclear. The mRNA levels ubiquitin-specific peptidase 37 (USP37) tissues fibroblasts were determined by quantitative real-time PCR. Western blot was performed to measure protein SALL4, USP4/10/37, collagen-related markers, PI3K/AKT-related markers. growth, invasion migration using CCK8 assay, EdU flow cytometry, transwell assay...
Submental fat (SMF) is a common aesthetic concern traditionally treated with liposuction. Non-surgical alternatives like injectable deoxycholic acid are gaining popularity. However, no related products have been clinically approved in China. This study evaluated the efficacy and safety of MEI005, acid-based formulation, reducing SMF Chinese adults. multicenter, randomized, double-blind, placebo-controlled phase III trial included 325 adults moderate to SMF. Participants received MEI005 or...
Autologous fat grafting has been widely used in plastic surgery recent years, but the unstable retention of graft always a key clinical problem. Adipose tissue poor tolerant to ischemia, so transplanted adipose needs rebuild blood supply at an early stage order survive stably. Our previous study found that comparing human foreskin fibroblast exosome (HFF-Exo), adipose-derived stem cells (hADSC-Exo) can significantly improve proliferation vascular endothelial and angiogenic effect artificial...
Reconstruction of the auricular conchal cavity is relatively difficult because its unique structure, shape, and location. We compared different methods repair concha to determine method that would cause least injury donor site. The selected was based on location size defect. If defect located in upper part concha, or if >15 mm diameter, we used a post-auricular subcutaneous pedicle island flap pulled through sulcus tunnel cover wound. lower <15 pre-auricular translocation passed intertragic...
Abstract Background One popular and well-established marker for the immune checkpoint blockade (ICB) response is tumor mutation burden (TMB). Persistent TMB (pTMB), a subset of TMB, provides better indicator to predict patient ICB therapy outcomes, as shown by some studies. Immune drugs have significantly changed how melanoma treated in recent years. Methods In this study, we integrated TCGA-SKCM database data pTMB TCGA from paper that first mentioned analyzed mutational characteristics...
Abstract Background Several cathepsins have been identified as being involved in the development of cancer. Nevertheless, connection between and skin cancers remained highly elusive. Methods A bidirectional Mendelian randomization (MR) analysis was performed to investigate causal association malignancies. The genome‐wide studies (GWAS) data for cathepsins, malignant melanoma (MM), basal cell carcinoma (BCC) were obtained from European research. primary method employed inverse variance...
To describe a modified surgical procedure that uses combination of the tarsoconjunctival flap, orbicularis myocutaneous advancement and paranasal-island flap to correct extensive full-thickness lower eyelid defects in functioning eyes.From May 2010 December 2013, total 15 patients had reconstructive surgeries large giant defect, with an average 19-month follow-up. The musculocutaneous flaps were harvested from both paranasal regions clinical outcomes recorded analyzed.No major complications...
We aimed at evaluating the effects of hydrosurgery and traditional surgical approach with two parallel incisions in treatment osmidrosis.This prospective study enrolled patients axillary osmidrosis between January 2015 November 2016. For hydrosurgery, a 1-cm-long incision was made middle posterior long axis. The hand piece turned upside down processed 'W-O' way. method, 3-cm-long were transversely. Patient demographics, complications, duration procedures outcomes collected compared. All had...
The nasal tip is a prominent landmark on the face, and skin carcinomas of this area are very common. Moderate large deep defects normally represent difficult reconstructive challenge. Nasal-tip reconstruction techniques have evolved to allow not only filling gap, but cosmetic functional retention. Numerous flap options available reconstruct defect nose. In paper, we report technique axial frontonasal its use in nasal-tip East Asians. described good alternative for > 15 mm diameter, with...
The hERCC 2 gene is an important DNA repair molecule for initiating Cutaneous melanoma ( CM ). Therefore, it advisable to study the possible functional SNV s in . To achieve this goal, we collected total 2, 253 from EMBL website, of which 303 are non‐synonymous single nucleotide variants (ns s). Then, SIFT and PolyPhen were used predict damaging ns s, four (rs368866996, rs377739017, rs370819591, rs121913022) suggested be mutations. Since I‐Mutant2.0 showed a decrease stability mutants...
Abstract Objective We aimed to explore the efficacy of keystone flap combined with vacuum‐assisted closure (VAC) in repair sacrococcygeal wounds. Methods This study is a retrospective review patients undergoing reconstruction between January 2014 and 2018. A standardized data collection template was used collect related variables. The detailed process reconstructive surgery carefully described this study. postoperative healing closely observed. Results Twelve underwent average wound size...