A5027132791- MicroRNA in disease regulation
- Cardiovascular Health and Disease Prevention
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- MRI in cancer diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Intracranial Aneurysms: Treatment and Complications
- Coronary Interventions and Diagnostics
- Palliative Care and End-of-Life Issues
- Lipid metabolism and disorders
- Dialysis and Renal Disease Management
- Family Caregiving in Mental Illness
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Atherosclerosis and Cardiovascular Diseases
- Inflammasome and immune disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Glycation End Products research
Pudong Medical Center
2021-2025
Fudan University
2021-2025
Acute myocardial infarction (AMI) is associated with well-established metabolic risk factors, especially hyperlipidemia and obesity. Myocardial ischemia-reperfusion injury (mIRI) significantly offsets the therapeutic efficacy of revascularization. Previous studies indicated that disrupted lipid homeostasis can lead to peroxidation damage inflammation, yet underlying mechanisms remain unclear. Here, study demonstrates a key driver mIRI. Long-chain fatty acyl-CoA synthetase 1 (ACSL1)...
Cerebral ischemia-reperfusion injury (CIRI) leads to cognitive dysfunction, neuronal death, and inflammation. Understanding the molecular mechanisms underlying CIRI is crucial for developing effective therapeutic strategies. This study aims investigate roles of activating transcription factor 3 (Atf3) lon protease homolog 1 (Lonp1) in CIRI, particularly focusing on how Atf3 regulates Lonp1 expression its effects mitochondrial function. Single-cell transcriptomics proteomic analyses were...
ABSTRACT Background To explore the therapeutic and preventive effect of dendritic cells injection combined with radical prostatectomy on prostate cancer in mice. Methods We extracted antigens from mouse RM‐1 cocultured them to induce maturation. constructed situ carcinoma subcutaneous tumor models prostate. The efficacy cell was evaluated model, ability prevent model. Means assessment included ultrasonography, flow cytometry analysis, Elisa. Results Dendritic effectively inhibited growth...
Carotid atherosclerosis is a chronic inflammatory disorder and responsible for the vast majority of ischemic strokes. Inappropriate innate adaptive immune responses synergize with malfunctional vascular wall cells to cause atherosclerotic lesions. Yet, functional characteristics specific endothelial cell subsets associated cerebrovascular events are poorly understood.
Transcarotid artery revascularization (TCAR) is thought to be a promising technique and instrument for treating carotid stenosis with favorable outcomes. Since there remain several differences in anatomic characteristics among races, this study was conducted investigate the eligibility of TCAR Chinese patients who underwent revascularization.A retrospective review from 2019 2021 conducted. The based on instruction ENROUTE Neuroprotection System. configuration circle Willis (CoW) were...
Background: Exosomes-encapsulated microRNAs (miRNAs) have been established to be implicated in the pathogenesis of different diseases. Nevertheless, circulating exosomal miRNAs thromboangiitis obliterans (TAO) remains poorly understood. This study aimed explore effects associated with TAO on human vascular smooth muscle cells (HVSMCs).Methods: The exosomes were isolated from plasma patients and normal controls then sent for small RNA sequencing. Differentially expressed (DE-miRNAs)...
The aim of this study is to identify the peri-procedural risk factors and outcomes hemodynamic instability (HI) after carotid artery stenting (CAS).A single-center, retrospective was performed in 168 patients who underwent CAS procedure between September 2017 2020. presence HI, as defined by hypertension (systolic blood pressure >160 mmHg), hypotension <90 and/or bradycardia (heart rate <60 bpm), recorded. Long-period HI persistent lasting more than 24 h. Patient demographics, comorbidities,...
Thromboangiitis obliterans (TAO) is a non-atherosclerotic, segmental, chronic vascular inflammatory disease. Our aim was to explore the underlying mechanisms of long non-coding RNA (lncRNA)-related competing endogenous RNAs (ceRNAs) in TAO. Six blood samples were collected from patients with TAO and healthy individuals (three for each category). Total extracted participant sequenced. Differentially expressed lncRNAs (DE-lncRNAs) miRNAs (DE-miRNAs) screened, ceRNA networks associated...
The objective of this study was to evaluate the effect continuity care on self-management ability and quality life (QOL) in patients undergoing maintenance hemodialysis (MHD).One hundred were randomly assigned observation group control group. In group, received a 12-month care. given with routine nursing. Evaluate patients' QOL between two groups 1 week before discharge 6 12 months outpatient MHD.Observation had higher Hemodialysis Self-Management Instrument (HD-SMI) scores Kidney Disease...
Background/Objectives: The purpose of this study was to develop the gemcitabine-loaded drug-eluting beads (G-DEBs) for transarterial chemoembolization (TACE) in rabbit renal tumors and evaluate their antitumor effect using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography/X-ray computed tomography (18F-FDG PET/CT). Methods: DEBs were prepared by polyvinyl alcohol-based macromer crosslinked with N-acryl tyrosine N,N′-methylenebis(acrylamide). Gemcitabine loaded through ion change...
Objective. This study aimed to identify circular RNA profiles (circRNAs) via high-throughput sequencing and distinguish the differentially expressed (DE) circRNAs between stable unstable plaques. Methods. was performed on carotid plaque samples obtained from patients with artery stenosis. DE were screened, six verified using quantitative real-time PCR (qRT-PCR). Functional evaluation of conducted Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses. Results....
Plaque vulnerability is associated with the degree of carotid artery stenosis (CS) and risk stroke. MicroRNAs (miRNAs) exert critical functions in disease progression, although only a few miRNAs have been well identified CS. Therefore, this study aimed to investigate differential expression profile their potential plaques CS patients. Three patients stable three vulnerable who underwent endarterectomy were enrolled study. Differentially expressed (DEmiRNAs) between determined using small RNA...