A5051456425- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Neurotransmitter Receptor Influence on Behavior
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- MRI in cancer diagnosis
- Schizophrenia research and treatment
- Pain Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Parkinson's Disease Mechanisms and Treatments
- Bone health and treatments
- Retinopathy of Prematurity Studies
- Functional Brain Connectivity Studies
- Forensic Toxicology and Drug Analysis
- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Cancer Cells and Metastasis
- Diet and metabolism studies
- Medical Imaging and Pathology Studies
- Estrogen and related hormone effects
Fudan University
2016-2025
Pudong Medical Center
2021-2025
Huashan Hospital
2016-2025
Johns Hopkins University
2011
GTx (United States)
2011
Chung Shan Hospital
2010
(177)Lu-labeled ethylenediamine-N,N,N',N'-tetrakis methylene phosphonic acid ((177)Lu-EDTMP), was used to palliate metastatic bone pain as a new bone-seeking radiopharmaceutical. In this phase II study, we assessed the efficacy and safety of (177)Lu-EDTMP for palliation in patients with breast cancer hormone refractory prostate metastases.Sixteen were enrolled trial subsequently divided into 2 groups, low-dose group (1295 MBq) high dose (2590 determine differences toxicities response rates....
To reveal the natural correlation between prostate-specific membrane antigen (PSMA) imaging and tumor neovascularization in prostate cancer further explore E-urea-K-based PSMA-targeted (EK-PSMA) as a potential indicator of neovascularization, 22Rv1 mouse models were established underwent 99mTc-HYNIC-ALUG SPECT/CT. Pearson analysis was applied to assess relationship tracer uptake characteristics, including size, glucose metabolism, cell phenotypes (e.g., Ki-67, VEGF, CD31, PSMA). Then,...
OBJECTIVE Chronic frontal hemodynamic disturbances are associated with executive dysfunction in adult patients moyamoya disease (MMD). However, the impact of surgical revascularization on and its underlying mechanism remains unclear. The aim present study was to examine postoperative radiological correlates cognitive improvement thereby explore mechanism. METHODS Fourteen who met inclusion criteria were identified at Huashan Hospital, operated on, successfully followed up for 6 months....
Estrogen receptor beta (ERβ) is an important ER subtype that plays crucial roles in many physiological and pathological disorders. Herein, we developed the probe [18F]PVBO for vivo ERβ targeted PET imaging obtained promising results. The nonradioactive PVBO showed a 12.5-fold stronger binding affinity to than ERα vitro. In vitro assays revealed specific uptake of by DU145 cells. xenografts increased during 120 min dynamic scanning, with maximum 2.80 ± 0.30% ID/g. Based on time activity...
Circulating tumor cells (CTCs) are valuable in both basic research and clinical application for cancer management. In the current study, we evaluated diagnostic value of CTCs pancreatic ductal adenocarcinoma (PDAC).In total, 143 blood samples from 95 consecutively diagnosed PDAC patients 48 healthy donors were collected. Combined data immunostaining CD45, DAPI fluorescence situ hybridization (FISH) with chromosome 8 centromere (CEP8) probe used to identify CTCs. Cells features...
Azide is an important chemical functional group and has been widely used in biology. However, the impact of azide on vivo behaviors compounds rarely studied. Herein, was introduced into a fluorescent dye for near-infrared window two (NIR-II) bone imaging. Specifically, we designed synthesized small-molecule NIR-II dyes, N3-FEP-4T capped with FEP-4T without capping. In vitro assays revealed that showed 5- 5.6- times higher hydroxyapatite accumulation macrophage uptake than those FEP-4T,...
Myelin pathology is present in many neurological conditions such as multiple sclerosis (MS) and traumatic spinal cord injury (SCI). To facilitate development of novel therapies aimed at myelin repair, we set out to develop imaging agents that permit direct quantification myelination vivo. In this work, designed synthesized a series fluorescent fluorinated can be used for vivo positron emission tomography (PET) combined with subsequent post-mortem cryoimaging. Structure–activity relationship...
Mitochondria-targeting positron emission tomography (PET) and fluorescent dual-modal probes are rarely reported. As one of the most promising lipophilic cations, F16 its derivatives (F16s) have never been used for myocardial imaging. In this work, 14 F16s synthesized evaluated cardiac vitro cell fluorescence imaging revealed that lead probe 5MEF is precisely localized in mitochondria cardiomyocytes. addition, it shows excellent ex vivo quality with heart-to-muscle heart-to-liver ratios up to...
In addition to causing white matter lesions, chronic cerebral hypoperfusion (CCH) can also cause damage gray matter, but the underlying molecular mechanisms remain largely unknown. order obtain a better understanding of relationship between gene expression and transcriptional regulation alterations, novel upstream regulators could be identified using integration analysis transcriptome epigenetic approaches. Here, bilateral common carotid artery stenosis (BCAS) model was established for...
Objectives Lutetium-177-labeled ethylenediamine-N,N,N′,N′-tetrakis (methylene phosphonic acid) (177Lu-EDTMP), a beta-emitting bone-seeking therapeutic radiopharmaceutical being assessed as an agent for palliation of bone pain, can emit suitable gamma-photons scintigraphy. This investigation sought to characterize its optimal conditions whole-body gamma camera imaging in patients. Materials and methods Eleven patients with metastases underwent scanning using both 99mTc-methyl-diphosphonate...
Chronic excess of growth hormone (GH) often leads to systemic complications. The reversibility these complications after GH resolution is not fully understood.To investigate when and what extent will the comorbidities be ameliorated.We conducted a prospective study comprising 24 patients with acromegaly, who achieved remission transsphenoidal surgery. dynamic changes endocrine, cardiovascular, respiratory, sleep, bone morphology parameters were evaluated at enrollment 1 week, month, 3...
Abnormal accumulation amyloid-β (Aβ) is recognized as one of the crucial factors for progression and pathology AD, which has accelerated development new chemical agents or technology early mapping monitoring Aβ plagues. While plaques from diffuse to highly compacted (dense-core), most reported dyes probes could only stain core Aβ, due lack technology, research on periphery was always ignored. Herein, we a near-infrared (NIR) fluorescent probe named Dicyano-3, had capability both plaques....
Abstract Background Sarcopenia, an age-related disorder characterized by loss of skeletal muscle mass and function, is recently recognized as a complication in elderly patients with type 2 diabetes mellitus (T2DM). Skeletal muscles play crucial role glycemic metabolism, utilizing around 80% blood glucose. Accordingly, we aimed to explore the relationship between glucose metabolism T2DM. Methods We employed AWGS 2019 criteria for diagnosing low 1999 World Health Organization (WHO) diagnostic...
Circulating tumor cells (CTCs) are an important topic of investigation for both basic and clinical cancer research. In this prospective study, we evaluated the role CTCs in ampullary cancer. We analyzed blood samples from 62 consecutively diagnosed patients with adenocarcinoma 24 healthy controls their CTC content. Combined data immunostaining CD45, 4',6-diamidino-2-phenylindole (DAPI), fluorescence situ hybridization a chromosome 8 centromere (CEP8) probe were used to identify CTCs; that...
Contezolid (MRX-I), a novel oxazolidinone antibiotic, was recently approved for the treatment of serious Gram-positive infections. The pharmacokinetics and disposition [14C]contezolid were investigated in single-dose human mass balance study. Cross-species comparison plasma exposure contezolid metabolites performed, safety disproportionate metabolite evaluated with additional nonclinical studies. After an oral administration 99.1 μCi/602-mg dose [14C]contezolid, approximately 91.5%...