A5103000391- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Function and Risk Factors
- Thyroid Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Urinary Tract Infections Management
- Cell Adhesion Molecules Research
- Digital Image Processing Techniques
- Insects and Parasite Interactions
- Medical Imaging and Pathology Studies
- Radioactive Decay and Measurement Techniques
- Gout, Hyperuricemia, Uric Acid
- Pulmonary Hypertension Research and Treatments
- Oral and gingival health research
- MRI in cancer diagnosis
- Monoclonal and Polyclonal Antibodies Research
- Ophthalmology and Eye Disorders
- Cardiac Health and Mental Health
- Advanced Radiotherapy Techniques
- Protease and Inhibitor Mechanisms
- Lung Cancer Research Studies
Tongji University
2021-2025
Shanghai Pulmonary Hospital
2021-2025
First Affiliated Hospital of Xiamen University
2020-2024
Xiamen University
2024
Fujian Medical University
2014-2022
Huaqiao University
2021
Quanzhou Normal University
2017
Guangzhou Medical University
2008-2016
First Affiliated Hospital of Guangzhou Medical University
2008-2016
University of Southern California
2005
We tried to unveil the clinical significance of miR-146a as a biomarker in M2 macrophage polarization diabetic wound healing. Initially, we found reduced macrophages patients. Next, dual-luciferase assay verified that toll-like receptor 4 (TLR4) was target gene miR-146 and negatively regulated by miR-146. Moreover, after ectopic expression depletion experiments and/or TLR4, lipopolysaccharide-induced inflammatory response detected. The results revealed overexpression promoted suppressing...
Occult nodal metastasis (ONM) plays a significant role in comprehensive treatments of non-small cell lung cancer (NSCLC). This study aims to develop deep learning signature based on positron emission tomography/computed tomography predict ONM clinical stage N0 NSCLC. An internal cohort (n = 1911) is included construct the (DLNMS). Subsequently, an external 355) and prospective 999) are utilized fully validate predictive performances DLNMS. Here, we show areas under receiver operating...
Tumor necrosis treatment (TNT) uses degenerating tumor cells and necrotic regions of tumors as targets for radioimmunotherapy. Previous studies in animal models clinical trials have demonstrated that when linked to the therapeutic radionuclide iodine-131, recombinant chimeric TNT antibody ((131)I-chTNT) can deliver doses regardless location or type malignancy. Therapeutic efficacy toxicity (131)I-chTNT advanced lung cancer patients were studied this pivotal registration trial.Patients with...
To reveal the natural correlation between prostate-specific membrane antigen (PSMA) imaging and tumor neovascularization in prostate cancer further explore E-urea-K-based PSMA-targeted (EK-PSMA) as a potential indicator of neovascularization, 22Rv1 mouse models were established underwent 99mTc-HYNIC-ALUG SPECT/CT. Pearson analysis was applied to assess relationship tracer uptake characteristics, including size, glucose metabolism, cell phenotypes (e.g., Ki-67, VEGF, CD31, PSMA). Then,...
The role of host microbes in the pathogenesis several diseases has been established, and altered microbiomes have related to diseases. However, variability urinary microbiome individuals with gout not evaluated date. Therefore, we conducted present prospective study characterize gut its potential relation gout. Urine samples from 30 patients healthy controls were analyzed by Illumina Miseq sequencing 16S rRNA hypervariable regions, compared according alpha-diversity indices, complexity...
A 56-year-old woman presented with edema in the upper part of body, enlarged axillary lymph nodes, and progressive bone pain for 1 year. Malignant disease was initially suspected. This patient underwent 68Ga-DOTA-FAPI-04 PET/CT detection primary lesion evaluation extent. revealed multiple abnormal foci at skeleton, muscle, subcutaneous fat. The imaging findings, highly suggestive Erdheim-Chester disease, have been later confirmed by histopathology. case highlights that would be useful...
Minor salivary gland (MSG) biopsy is a critical but invasive method for the classification of primary Sjögren's disease (pSjD). Here we aimed to identify proteins as potential biomarkers and establish non-invasive prediction model pSjD. Liquid chromatography-tandem mass spectrometry was conducted on whole saliva samples from patients with pSjD non-Sjögren control subjects (non-pSjD). Proteins involved in immune processes were upregulated group, such complement C3 (C3), factor B (CFB),...
Ruozhu Dai, Huilin Zhuo, Yangchun Chen, Kelian Zhang, Yongda Dong, Chengbo Chen and Wei Wang. Mechanism of isosorbide dinitrate combined with exercise training rehabilitation to mobilize endothelial progenitor cells in patients coronary heart disease. Bioengineered. 2021 Nov. doi: 10.1080/21655979.2021.2000258.Since publication, significant concerns have been raised about the compliance ethical policies for human research integrity data reported article.When approached an explanation,...
In this study, we aimed to evaluate the efficacy of thyroid volume measurement using 99mTc pertechnetate single-photon emission computed tomography (SPECT) images, acquired by standardized uptake value (SUV)-shape scheme designed our expert team.A total 18 consecutive patients with Graves' disease (GD) were subjected both ultrasonographic and SPECT examinations within a five-day interval. The lobes isthmus was measured ultrasonography (US) according ellipsoid equation. volume, determined as...
A perfusion-ventilation lung SPECT image analysis system is developed in this paper. The applies the minimum cross-entropy threshold selection method to recognizing from image, and utilizes watershed segmentation separate right left pulmonary lobes. In system, a contour tracing operator used detect edge of lobe. can automatically divide lobe into 9 regions calculate radiation counts its proportion total counts. Finally, manage medical information database store perfusion ventilation images...
Fluorine-18-fluorodeoxyglucose (18F-FDG) injection activity is positively associated with radiation dose and positron emission tomography (PET) image count. Measurement error greater smaller counts; therefore, precise analysis needed to avoid high doses of exposure caused by 18F-FDG injection. We aimed identify validate the optimal acquisition time for cardiac viability imaging intravenous insulin preparation administration based on fixed activity.Cardiac PET images from 30 patients coronary...
Considering the fact that standardized uptake value (SUV) of a normal lung tissue is expressed as x±SD, x+3×SD could be considered threshold to outline internal tumor volume (ITV) neoplasm.Three hollow models were filled with 55.0 kBq/mL fluorine-18 fluorodeoxyglucose (18F-FDG) represent tumors. The fixed barrel 5.9 18F-FDG characterize tissues phantom. PET/CT images phantom acquired at rest. Then, was moved periodically simulate breathing while acquiring data. Volume recovery coefficient...
The aim of this study was to evaluate the relative error (RE) in thyroid absorbed dose (TD) iodine-131 (131I) patients with Graves' disease comparing simplified Quimby-Marinelli-Hine formula method (sQMHF) and Standard Operational Procedures for dosimetry (SOPD) recommended by European Association Nuclear Medicine.This included 45 12 men 33 women; age 44.1±12.8 years. Thyroid mass (TM) measured using ultrasound. Uptake 131I (RAIU) tested at 2, 4-6, 24, 48-72, 96-168h after its administration...
Objective To explore the epidemiology and imaging characteristics of spinal lymphoma, provide evidence for early diagnosis. Methods China National Knowledge Infrastructure (CNKI), Wanfang Vip electronic database were searched articles regarding lymphorna. The key words spine, lymphorna, epidural. Using Meta analysis, 20 meeting criteria including 152 cases studied. Results mean age at diagnosis was 37.3 years old, male female ratio 1.9:1, diseased region thoracic segments spine 66.9% all...
This study aimed to investigate the relationship between standardised uptake value of free wall right ventricular myocardium (SUVrv) and left end-diastolic volume (LVEDV) among patients with heart failure reduced ejection fraction (HFrEF) coronary artery disease (CAD). retrospective included 50 CAD HFrEF scheduled for cardiac viability imaging electrocardiography-gated fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). The maximal SUVrv was...
Abstract Purpose This study aimed to identify and validate the optimal 18 F-FDG activity acquisition time for cardiac viability imaging with intravenous insulin administration based on a fixed activity. Methods Cardiac positron emission tomography (PET) images from 30 patients coronary artery disease (CAD) were retrospectively reconstructed into 900, 360, 180, 90, 45 s durations. An product of maximum standardized uptake value (SUV) myocardium segmental (SU) (MSAT) was determined through...
Abstract Purpose This study aimed to identify and validate the optimal 18 F-FDG activity acquisition time for cardiac viability imaging with intravenous insulin administration based on a fixed activity. Methods Cardiac positron emission tomography (PET) images from 30 patients coronary artery disease (CAD) were retrospectively reconstructed into 900, 360, 180, 90, 45 s durations. An product of maximum standardized uptake value (SUV) myocardium segmental (SU) (MSAT) was determined through...