A5002525535- Salivary Gland Disorders and Functions
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Cell Adhesion Molecules Research
- Spondyloarthritis Studies and Treatments
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Reproductive System and Pregnancy
- Bone Metabolism and Diseases
- Glycosylation and Glycoproteins Research
- Autoimmune and Inflammatory Disorders Research
- Platelet Disorders and Treatments
- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- CNS Lymphoma Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Viral Infections and Vectors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Hematological disorders and diagnostics
- Eosinophilic Disorders and Syndromes
- IL-33, ST2, and ILC Pathways
- Mosquito-borne diseases and control
First Affiliated Hospital of Xiamen University
2014-2024
Xiamen University
2017-2024
Nantong Tumor Hospital
2022-2023
Nantong University
2022-2023
Xiamen Blood Center
2022
PLA Navy General Hospital
2015
Capital Medical University
2012-2014
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2012
Institute of Cancer Research
1991
Fibroblast-like synoviocytes (FLS) are the main cell component in inflamed joints of patients with rheumatoid arthritis (RA). FLS intimately interact infiltrating T cells. Fibroblasts have potent inhibitory effects on cells, leading to resolution inflammation and immune tolerance. However, this "regulatory" phenotype is defect RA, RA instead act as "proinflammatory" mediating perpetuation. Signals that orchestrate fibroblast heterogeneity remain unclear. Here, it demonstrated different...
To clarify clinical characteristics of immune thrombocytopenia (ITP) subsets associated with autoimmune diseases (AIDs). Five thousand five hundred twenty patients were reviewed retrospectively. One four ITP included for analysis. Clinical manifestations at first thrombocytopenic episode recorded. Systemic lupus erythematosus (SLE) and primary Sjogren syndrome (pSS) accounted a large part in AIDs secondary ITP. SLE-ITP, pSS-ITP, (pITP) different several aspects immunological characteristics....
Abstract Microdamage and its related inflammation contribute to the development of radiographic axial spondyloarthritis (r-axSpA). Inflammation cell death in damaged tissues are associated with cell-free DNA (cfDNA) release. Here we investigated whether circulating cfDNA could be a potential biomarker for evaluating disease activity treatment response r-axSpA. Circulating was detected discovery validation cohort 79 60 newly diagnosed r-axSpA patients respectively 42 healthy controls using...
Interleukin-33 (IL-33), the most recently discovered member of IL-1 superfamily, has been linked to several human pathologies including autoimmune diseases, sepsis, and allergy through its specific receptor ST2. However, there is little information regarding role IL-33 in gout. In this study, we investigated potential gout patients. The serum level was measured by ELISA, clinical laboratory parameters, creatinine, urea, lipid, were extracted from medical record system. expression...
The role of host microbes in the pathogenesis several diseases has been established, and altered microbiomes have related to diseases. However, variability urinary microbiome individuals with gout not evaluated date. Therefore, we conducted present prospective study characterize gut its potential relation gout. Urine samples from 30 patients healthy controls were analyzed by Illumina Miseq sequencing 16S rRNA hypervariable regions, compared according alpha-diversity indices, complexity...
The neurological involvement associated with primary Sjögren's syndrome (pSS) can be life threatening. However, the specific characteristics of pSS-related remain obscure. This study aimed at determining clinical this in patients pSS.The data 205 pSS who were admitted to our department between January 2015 and June 2017 studied. Characteristics laboratory findings abnormalities compared without.Forty exhibited (19.51%); these, 13 central nervous system (CNS) only, 20 peripheral (PNS) 7 both,...
Objective: Clinical characteristics of immune thrombocytopenia (ITP) associated with primary Sjögren's syndrome (pSS) have not been clearly defined. This study aimed to evaluate the prevalence and secondary ITP in patients pSS. Methods: A total 291 pSS our hospital were retrospectively analyzed. manifestations laboratory findings compared between without ITP. Results: The was 12.03%. Compared ITP, younger had higher disease activity. interstitial lung diseases (ILD) significantly lower...
Background: Increased platelet count has been reported in ankylosing spondylitis (AS) patients, but its clinical significance is still largely elusive. The objective of this study was to evaluate the role AS especially impact on treatment outcomes. Methods: A case-control containing 35 patients receiving anti-tumor necrosis factor-α (anti-TNF-α) therapy and 45 healthy controls performed, were followed at least 6 months after anti-TNF-α therapy. systematic review meta-analysis studies...
Background:The clinical serum markers CA125 and D-dimer have been reported to predict lymph node metastasis(LNM) in several malignant tumors, but the reports ovarian cancer(OC) are still absent.The purpose of this study was explore value indicator combined with (ICD) predicting LNM patients OC.Methods: A total 447 diagnosed OC from January 2008 June 2019 were included retrospective as training set.A 284 validation set.The optimal cut-off critical ICD evaluated by receiver operating...
Background The mechanisms of doxorubicin (DOX) cardiotoxicity were complex and controversial, with various contradictions between experimental clinical data. Understanding the differences in molecular mechanism DOX-induced acute chronic may be an ideal entry point to solve this dilemma. Methods Mice injected intraperitoneally DOX [(20 mg/kg, once) or (5 mg/kg/week, three times)] construct models, respectively. Survival record ultrasound monitored cardiac function. corresponding left...
Minor salivary gland (MSG) biopsy is a critical but invasive method for the classification of primary Sjögren's disease (pSjD). Here we aimed to identify proteins as potential biomarkers and establish non-invasive prediction model pSjD. Liquid chromatography-tandem mass spectrometry was conducted on whole saliva samples from patients with pSjD non-Sjögren control subjects (non-pSjD). Proteins involved in immune processes were upregulated group, such complement C3 (C3), factor B (CFB),...
Fas and its ligand FasL, members of tumor necrosis factor receptor superfamily, have been implicated in the process cell apoptosis. FasL consists two forms, membrane (mFasL) soluble (sFasL). sFasL can be produced by mFasL cleaved matrix metalloproteinases (MMP) also reveals a role for binding to which is expressed on surface. Although Fas/FasL axis has variety diseases, Sjogren's syndrome still remains ill defined. In this study, we investigated potential pathogenesis (SS). We found that...