A5100527585- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- RNA modifications and cancer
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Adenosine and Purinergic Signaling
- Metabolism, Diabetes, and Cancer
- Neuropeptides and Animal Physiology
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Mast cells and histamine
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- Pediatric Hepatobiliary Diseases and Treatments
- Acupuncture Treatment Research Studies
- Fibroblast Growth Factor Research
- Cancer, Stress, Anesthesia, and Immune Response
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Protein purification and stability
- FOXO transcription factor regulation
Sun Yat-sen University
2018-2024
The First Affiliated Hospital, Sun Yat-sen University
2018-2024
Zhongshan Hospital
2018-2024
Fudan University
2017-2024
First Affiliated Hospital of Kunming Medical University
2024
Zhongshan Hospital of Xiamen University
2024
Pennsylvania State University
2024
Institut des Sciences Analytiques et de Physico-Chimie pour l'Environnement et les Matériaux
2024
University College London
2024
Kunming Medical University
2024
T cell-redirecting bispecific antibodies are specifically designed to bind tumor-associated antigens, thereby engaging with CD3 on the cell receptor. This linkage between tumor cells and actively triggers activation initiates targeted killing of identified cells. These have emerged as one most promising avenues within immunotherapy. However, despite success in treating hematological malignancies, significant advancements solid tumors yet be explored. In this review, we aim address critical...
Diabetes mellitus and pancreatic cancer are intimately related. Our previous studies showed that high levels of blood glucose promote epithelial-mesenchymal transition cancer. In this study, we evaluated the relationship between hyperglycemia hypoxic tumor microenvironments.HIF-1α expression was by immunohistochemistry in clinical tissues with or without diabetes mellitus. Statistcal analysis performed to explore HIF-1α pathological features patients vivo vitro models established detect...
Abstract Background Gallstones are the cause of a majority biliary tract discomfort. Although many community-based studies have addressed risk factors for gallstone disease (GSD), little is known about GSD prevalence and in Chinese populations. Methods From January 2014 to 2015, participants ( N = 2,068,523) were recruited by Meinian Onehealth Healthcare Co., Ltd. They received physical examination, was determined ultrasound. Results The 8.1%. Risks similar between males females all age...
Circulating tumor cells (CTCs) are valuable in both basic research and clinical application for cancer management. In the current study, we evaluated diagnostic value of CTCs pancreatic ductal adenocarcinoma (PDAC).In total, 143 blood samples from 95 consecutively diagnosed PDAC patients 48 healthy donors were collected. Combined data immunostaining CD45, DAPI fluorescence situ hybridization (FISH) with chromosome 8 centromere (CEP8) probe used to identify CTCs. Cells features...
Tumor‐infiltrating neutrophils ( TIN ) carry out quite significant but opposite functions in different cancers, and their function biliary cancer has not been fully characterized. To investigate the prognostic significance of cancer, a training set (n = 118) validation 127) were involved this study. evaluated by immunohistochemical staining CD 66b, then defined as low (neutrophils <18/high‐power field [ HPF ]) vs high ≥18/ ). Kaplan‐Meier curve, Cox proportional hazards models receiver...
The study investigated the impact of dietary montmorillonite on growth performance, intestinal mucosal barrier, and microbial community in weaned piglets with control group (CON) supplementation 0.2% (0.2% M). Compared CON group, M feed diet increased average daily gain (ADG) days 15–35 day 1–35 intake (ADFI) (0.05 &lt; P 0.1). Besides, higher villus height duodenum jejunum lower crypt depth colon were revealed than ( 0.05). Moreover, V/C (ratio depth) was compared to that both from...
Abstract Background A history of abdominal biliary tract surgery has been identified as a relative contraindication for laparoscopic common bile duct exploration (LCBDE), and there are very few reports about procedures in patients with surgery. Methods We retrospectively reviewed the clinical outcomes 227 consecutive previous operations at our institution between December 2013 June 2019. total 110 underwent LCBDE, 117 open (OCBDE). Patient demographics perioperative variables were compared...
Aims While etiology behind the observed acceleration of ischemic heart disease in postmenopausal women is poorly understood, collective scientific data suggest cardioprotective effects endogenous female sex hormone, estrogen. We have previously shown that 17β-estradiol (E2) protects cardiomyocytes exposed to hypoxia-reoxygenation (H/R) by inhibiting p38α - p53 signaling apoptosis and activating pro-survival p38β mitogen activated protein kinase (p38β MAPK), leading suppression reactive...
Introduction: This study was designed to explore the associations between impaired cognition in chronic kidney disease (CKD) patients and dysfunction of glymphatic system. Method: Data were obtained from 77 CKD 50 age-matched healthy control individuals First Affiliated Hospital Zhengzhou University. stratified into with without cognitive function. T2-weighted magnetic resonance imaging results used assess area ratios for perivascular space ventricles participants, while Montreal Cognitive...
Background Sepsis, affecting over 30 million people worldwide each year, is a key mortality risk factor in critically ill patients. There are significant regional discrepancies its impact. Acetaminophen, common over-the-counter drug, often administered to control fever suspected infection cases intensive care units (ICUs). It considered generally safe when used at therapeutic levels. Despite widespread use, there’s inconsistent research regarding efficacy sepsis management, which creates...
Background Large cell neuroendocrine carcinoma (LCNEC) is a rare and typically aggressive malignancy with poor prognosis. This study developed nomogram model to predict the overall survival (OS) of patients LCNEC. Methods LCNEC were identified from Surveillance, Epidemiology, End Results database between 2004–2014. Univariate multivariate Cox regression models used determine demographic clinicopathological features associated OS. A was generated OS its performance assessed by Harrell's...
Emerging evidence indicates carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is involved in the development of atherosclerosis (AS). However, roles and functions CEACAM1 AS remain unknown. Therefore, this study aims to investigate molecular AS. We constructed a diabetes mellitus (DM) + high-fat diet (HFD) mouse model based on streptozotocin (STZ)-induced apolipoprotein E-knockdown (ApopE-/-) regulatory mechanism miR-449a/CEACAM1 axis. The mRNA expression protein levels...
Circulating tumor cells (CTCs) are an important topic of investigation for both basic and clinical cancer research. In this prospective study, we evaluated the role CTCs in ampullary cancer. We analyzed blood samples from 62 consecutively diagnosed patients with adenocarcinoma 24 healthy controls their CTC content. Combined data immunostaining CD45, 4',6-diamidino-2-phenylindole (DAPI), fluorescence situ hybridization a chromosome 8 centromere (CEP8) probe were used to identify CTCs; that...
Abstract Recent studies have reported that tumor‐infiltrating mast cells (TIM) play an important role in tumor regression, but the effect of TIM gallbladder cancer (GBC) remains unclear. The present study aims to investigate prognostic value GBC patients and its responsiveness gemcitabine‐based adjuvant chemotherapy (ACT). A total 298 from Zhongshan Hospital were recruited for this study. infiltration was measured by immunohistochemical staining. Accumulation is significantly associated with...
Objective To detect the levels of serum bilirubin and uric acid as well their relationship with cognitive function in patients subcortical ischemic vascular disease (SIVD). Methods Serum direct (DBIL),indirect (IBIL),total (TBIL),uric (UA) risk factors were analyzed 238 individuals comprising 161 SIVD 77 controls normal function.SIVD divided into two subgroups: those impairment (SVMCI) dementia (SVaD).All them subject to assessment including Mini-mental State Examination(MMSE),the...
<b><i>Background:</i></b> The clinical benefits and efficacies of adjuvant therapies for gallbladder cancer (GBC) have not been verified due to insufficient evidence. <b><i>Methods:</i></b> Patients with resected nonmetastatic stage II–IV GBC were selected from the Surveillance, Epidemiology, End Results database distributed into nonchemotherapy chemoradiotherapy (NCRT), chemotherapy (CT), (CRT) groups. Generalized propensity score inverse...
Acute appendicitis is one of the most common acute abdominal emergencies around world, which always associated with infection. Infection
Background Alzheimer’s disease (AD) is increasingly recognized as a pressing global public health issue, demanding urgent development of scientific AD management strategies. In recent years, the proportion patients in Intensive Care Units (ICU) has been on rise. Simultaneously, use mechanical ventilation (MV) becoming more prevalent among this specific patient group. Considering pathophysiological characteristics AD, application MV may lead to different outcomes. However, due insufficient...