A5103151249- Genomics and Chromatin Dynamics
- Tendon Structure and Treatment
- Myofascial pain diagnosis and treatment
- RNA Research and Splicing
- Shoulder Injury and Treatment
- Phytochemicals and Antioxidant Activities
- Advanced Memory and Neural Computing
- Distributed and Parallel Computing Systems
- Wireless Body Area Networks
- Blind Source Separation Techniques
- Advanced Malware Detection Techniques
- Sports injuries and prevention
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Embedded Systems and FPGA Design
- Energy Efficient Wireless Sensor Networks
- Immune cells in cancer
- Bioinformatics and Genomic Networks
- EEG and Brain-Computer Interfaces
- Molecular Communication and Nanonetworks
- Peroxisome Proliferator-Activated Receptors
- Software Engineering Research
- Ion Transport and Channel Regulation
- Advanced Vision and Imaging
Center for Life Sciences
2021-2025
Peking University
2015-2025
Xinjiang University
2025
Shandong University of Science and Technology
2025
Fudan University
2014-2024
Huadong Hospital
2020-2024
University Health Network
2023-2024
University of Toronto
2024
Vector Institute
2023-2024
Yunnan University
2024
PD-L1 is an immune inhibitory receptor ligand that leads to T cell dysfunction and apoptosis by binding its PD-1, which works in braking inflammatory response conspiring tumor evasion. However, gliomas, the cause of expression microenvironment not yet clear. Besides, auxiliary biomarkers are urgently needed for screening possible responsive glioma patients anti-PD-1/PD-L1 therapies.The distribution tumor-infiltrating cells was analyzed via immunofluorescence orthotopic murine model. The...
RNA polymerase II (Pol II) apparatuses are compartmentalized into transcriptional clusters. Whether protein factors control these clusters remains unknown. In this study, we find that the ATPase-associated with diverse cellular activities (AAA + ) ATPase RUVBL2 co-occupies promoters Pol and various transcription factors. interacts unphosphorylated in chromatin to promote RPB1 carboxy-terminal domain (CTD) clustering initiation. Rapid depletion of leads a decrease number inhibits nascent...
To investigate the structure-antioxidant activity relationship, Pleurotus ferulae polysaccharides were extracted using ultrasonic (U-PFPS) and microwave/ultrasonic-assisted methods (MU-PFPS). Compared to U-PFPS with a molecular weight of 1.566 × 103 kDa, MU-PFPS exhibited lower 89.26 kDa. In addition, unlike U-PFPS, which is primarily composed glucose (Glu:Man:Gal = 91.1:3.5:5.4), has more balanced composition Glu:Man:Gal in ratio 39.4:27.8:32.8 contains branched chains. Furthermore,...
Abstract Background Gallstones are the cause of a majority biliary tract discomfort. Although many community-based studies have addressed risk factors for gallstone disease (GSD), little is known about GSD prevalence and in Chinese populations. Methods From January 2014 to 2015, participants ( N = 2,068,523) were recruited by Meinian Onehealth Healthcare Co., Ltd. They received physical examination, was determined ultrasound. Results The 8.1%. Risks similar between males females all age...
Auditory spatial attention detection (ASAD) aims to decode the attended location with EEG in a multiple-speaker setting. ASAD methods are inspired by brain lateralization of cortical neural responses during processing auditory attention, and show promising performance for task decoding (AAD) recordings. In previous methods, distribution electrodes is not fully exploited, which may limit these methods. present work, transforming original channels into two-dimensional (2D) topological map,...
Abstract Background Plantar fasciitis (PF) is the most common cause of heel pain. Among conservative treatments, extracorporeal shock wave therapy (ESWT) considered effective for refractory PF. Studies have shown that applying ESWT to trigger points (TrPs) in triceps surae may play an important role pain treatment patients with Therefore, purpose this study was combine concept and explore effect combination on plantar temperature pressure Methods After inclusion exclusion criteria, 86 PF...
1,2-Dichloroethane (1,2-DCE) is a pervasive environmental pollutant, and overexposure to this hazardous material causes brain edema demyelination in humans. We found that 1,2-DCE inhibits aquaporin 4 (AQP4) primary pathogenic effector of 1,2-DCE-induced animals. However, AQP4 down-regulation's link with cortex after exposure remains unclear. Thus, we exposed wild-type (WT) CD-1 mice knockout (AQP4-KO) 0, 100, 350 700 mg/m3 by inhalation for 28 days. applied label-free proteomics cell...
Pioneer transcription factors (PTFs) possess the unique capability to access closed chromatin regions and initiate cell fate changes, yet underlying mechanisms remain elusive. Here, we characterized single-molecule dynamics of PTFs targeting in living cells, revealing a notable "confined target search" mechanism. like FOXA1, FOXA2, SOX2, OCT4 KLF4 sampled more frequently than non-pioneer factor MYC, alternating between fast free diffusion nucleus slower confined within mesoscale zones....
Integrated waveguides with slot structures have attracted increasing attention due to their advantages of tight mode confinement and strong light-matter interaction. Although extensively studied, the issue mismatch other strip waveguide-based optical devices is a huge challenge that prevents integrated from being widely utilized in large-scale photonic-based circuits. In this paper, we demonstrate an ultra-compact low-loss slot-strip converter polarization insensitivity based on multimode...
The emergence and spread of highly pathogenic avian influenza (HPAI) A virus subtype H5N1 in Asia, Europe Africa has had an enormously socioeconomic impact presents important threat to human health because its efficient animal-to-human transmission. Many factors contribute the occurrence transmission HPAI virus, but role environmental temperature remains poorly understood. Based on approach integrating a Bayesian Cox proportional hazards model Besag-York-Mollié (BYM) model, we examined...
A high reliability system for the generation of truly random numbers, based on Resistive Random Access Memory (RRAM) has been proposed. The circuit is using telegraph noise (RTN) in RRAM cell as a source to force more jitter into oscillators. Because these RTN signals from cells are much larger than that MOSFET and thermal resistor, then preamplifier not required. prototype chip fabricated SMIC 0.18um standard CMOS logic process. test results show features proposed true number generator...
Ischemia reperfusion injury (IRI) is the major cause of intestinal damage in clinic. Although either mesenchymal stromal cells (MSCs) or interleukin 37 (IL-37) shows some beneficial roles to ameliorate IRI, their effects are limited. In this study, preventative IL-37 gene-modified MSCs (IL-37-MSCs) on IRI investigated. Intestinal model was established by occluding superior mesenteric artery for 30 minutes and then reperfused 72 hours rats. Forty adult male Sprague-Dawley rats were randomly...
Chronic viral hepatitis B (CHB) is a major global health problem. A therapeutic vaccine for CHB comprised of yeast-derived recombinant HBsAg-anti-HBs immunogenic complexes (YIC) has been devloped by us. series clinical trials shown its efficacy in decreasing HBV load and converting serum HBeAg-positive to anti-HBe-positive status subpopulation patients. Herein, we present study the immuno-potentiating mechanisms YIC revealed live-cell imaging technology. We studied internalization...
Ovarian cancer is the gynecologic tumor with highest fatality rate, and high-grade serous ovarian (HGSOC) most common malignant type of cancer. One important reason for poor prognosis HGSOC lack effective diagnostic prognostic biomarkers. New biomarkers are necessary improvement treatment strategies to ensure appropriate healthcare decisions.To construct co-expression network samples, we applied weighted gene analysis (WGCNA) assess proteomic data obtained from Clinical Proteomic Tumor...
Abstract Objectives To compare the long‐term efficacy between pulsed radiofrequency (PRF) combined with passive stretching (PRF‐PS) exercise and PS alone in reducing pain improving quadriceps muscle strength knee function. Methods Sixty‐two participants were randomly assigned a 1:1 allocation to PRF‐PS group or group. Level of pain, strength, function assessed from baseline first, third, sixth months after treatment using VAS, peak torque (PT), Western Ontario McMaster Universities...