A5006651679- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- DNA and Nucleic Acid Chemistry
- Advanced Fluorescence Microscopy Techniques
- Advanced oxidation water treatment
- Diffusion and Search Dynamics
- RNA modifications and cancer
- Electrochemical Analysis and Applications
- Membrane Separation Technologies
Center for Life Sciences
2024
Peking University
2015-2024
National Institute of Biological Sciences, Beijing
2024
Tsinghua University
2024
Pioneer transcription factors (PTFs) possess the unique capability to access closed chromatin regions and initiate cell fate changes, yet underlying mechanisms remain elusive. Here, we characterized single-molecule dynamics of PTFs targeting in living cells, revealing a notable "confined target search" mechanism. like FOXA1, FOXA2, SOX2, OCT4 KLF4 sampled more frequently than non-pioneer factor MYC, alternating between fast free diffusion nucleus slower confined within mesoscale zones....