A5100369882- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Nuclear Receptors and Signaling
- Venous Thromboembolism Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
- Vascular Malformations Diagnosis and Treatment
- Preterm Birth and Chorioamnionitis
- Signaling Pathways in Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone fractures and treatments
- Medical Research and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebral Venous Sinus Thrombosis
- Myofascial pain diagnosis and treatment
- Chemical Synthesis and Analysis
- Advanced MRI Techniques and Applications
- Traditional Chinese Medicine Studies
- Cardiac Ischemia and Reperfusion
- Parkinson's Disease Mechanisms and Treatments
- Reproductive tract infections research
- Neuropeptides and Animal Physiology
- Advanced Neuroimaging Techniques and Applications
- Tissue Engineering and Regenerative Medicine
McGill University
2024
Guangxi University
2024
Guangxi University of Chinese Medicine
2024
First Affiliated Hospital of Jinan University
2023
The First Affiliated Hospital, Sun Yat-sen University
2023
Sun Yat-sen University
2023
Shanghai Sixth People's Hospital
2022
Shanghai Jiao Tong University
2022
Fudan University
2019-2021
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2021
Abstract Ischemia-reperfusion injury (IRI) is an important cause of adverse prognosis after recanalization in patients with acute occlusion major intracranial artery (AOMIA). Here, we provided data indicating that gradual flow restoration (GFR) would be superior to rapid (RFR) alleviating cerebral IRIs middle (MCAO) rats. A total 94 MCAO rats 15, 30 and 60-minute were randomly assigned receive either GFR or RFR intervention. There significant differences between group mean neurological...
Progressive loss of dopaminergic (DA) neurons in the substantial nigra pars compacta (SNc) is an important pathological feature Parkinson's disease (PD). Loss transcription factor myocyte enhancer 2D (MEF2D), a key neuronal survival factor, has been shown to underlie DA SNc and pathogenic process PD. It known that PD-associated neurotoxins reduce level MEF2D protein trigger death. Although clearly destabilize by post-translational mechanisms, it not whether regulation mRNA contributes...
Background and Purpose: This study aimed to investigate the association between insulin resistance (IR) overall cerebral small vessel disease (CSVD) burden. Methods: We recruited elderly, nondiabetic, healthy subjects prospectively. The effect of CSVD on brain was described by a validated score. homeostasis model assessment-estimated index (HOMA-IR) used for IR estimation, HOMA-IR ≥2.80 defined as IR. evaluated increasing severity score ordinal regression models adjusting demographics...
Abstract The prominent vessel sign (PVS) on susceptibility-weighted imaging (SWI) is not displayed in all cases of acute ischemia. We aimed to investigate the factors associated with presence PVS stroke patients. Consecutive ischemic patients admitted within 24 h from symptom onset underwent emergency multimodal MRI at admission. Associated for were analyzed using univariate analyses and multivariable logistic regression analyses. A total 218 enrolled. occurrence rate was 55.5%. Univariate...
Using gene chip technology, we first identified that PGF 2 α (FP agonist) and Butaprost (EP induced about a five‐fold upregulation of Nur77 mRNA expression in hFP‐HEK 293/EBNA hEP ‐HEK293/EBNA cells. Northern Blot analysis revealed ‐ Butaprost‐induced are dose‐ time‐dependent. Both upregulated through the protein kinase C (PKC) pathway. These data showing link between EP receptor stimulation activation. Calcineurin was found to be involved downstream PKC pathway ‐induced expression, but not...
Abstract Background: Post-stroke depression (PSD) is one of the most common stroke complications with high morbidity. Researchers have done much clinical research on Traditional Chinese Medicine (TCM) treatment, but very little diagnosis. Based thought combination disease and syndrome, this study will establish a unified objective quantitative diagnosis model TCM syndromes PSD, so as to improve treatment PSD. Objective: First: To in PSD under different courses, identify corresponding main,...
Background Brain assessment shows great values in prognosis, treatment, resource allocation, and decision-making for patients with disorders of consciousness (DOC). However, less research focused on cortical conditions unresponsive wakefulness syndrome (UWS). Methods We recorded resting-state EEG TMS-EEG from post-anoxic UWS, diagnosed by repeated Coma Recovery Scale-Revised (CRS-R). Measurements functional connectivity networks were performed phase lock value (PLV) network parameters graph...
Stroke-related pneumonia (SAP) is a common complication in acute ischemic stroke (AIS) patients, and it has adverse effects on the clinical outcomes increases burden patients' families society. Early identification individualized care are necessary to reduce incidence of SAP.The present study aimed explore effect nurse-led hierarchical management based stroke-associated score (AIS-APS) scale AIS patients.A quasi-intervention pilot design was adopted for study. A total 120 patients were...
Both acute cerebral infarction and malignant tumors are prevalent in the elderly. However, is rarely present as first clinical manifestation of tumors. By searching Picture Archiving Communication System from 2010 to 2022 medical record database 2003 2022, we found three cases Trousseau syndrome, one male two females with an average age 69.3 ± 3.2 years, presenting infarction. Two patients denied having hypertension, diabetes, coronary heart disease. The value D-dimer was 17.83 12.39 mg/L...
We aimed to investigate the effect of chromodomain-helicase-DNA-binding protein 1-like (CHD1L) silencing on biological behavior gastric cancer cells.Small hairpin RNA (shRNAs) targeting CHD1L were designed and transduced into BGC-823 human cells. Expression p53, p21, nerve growth factor IB (Nur77), ARHGEF9 was assessed by western blotting, cell proliferation, apoptosis, migration examined MTT, flow cytometry, wound healing assays, respectively.In CHD1L-shRNA-1-treated cells, expression...
Background The past decade has witnessed advancements in mechanical thrombectomy (MT) for acute large-vessel occlusions (LVOs). However, only approximately half of the patients with LVO undergoing MT show best/independent 90-day favorable outcome. This study aimed to develop a nomogram predicting poor outcomes treated MT. Methods A total 187 who received were retrospectively analyzed. Factors associated (defined as mRS 4–6) determined by univariate and multivariate logistic regression...
The syncytiotrophoblast is a multinucleated structure that arises from fusion of mononucleated cytotrophoblasts, to sheath the placental villi and regulate transport across maternal-fetal interface. Here, we ask whether dynamic mechanical forces must arise during villous development might influence fusion, explore this question using in vitro choriocarcinoma trophoblast models. We demonstrate stress patterns around sites localized cell monolayers, match computational predictions...
Lumbar disc herniation (LDH) is a common lumbar disease that manifests itself as low back pain, leg numbness, and in severe cases, cauda equina neuropathy, it often occurs L4/L5 L5/S1 intervertebral discs. With the continuous change of people's work lifestyle, number patients with has also gradually increased, there significant trend rejuvenation. The mainly divided into conservative treatment surgical treatment, vast majority after symptoms have been significantly relieved, Chinese medicine...
Objective To investigate the relationship between asymmetric prominent hypointense vessels (prominent vessel sign, PVS) on susceptibility-weighted imaging (SWI) and leptomeningeal collateralization in patients with acute ischemic stroke due to large occlusion. Methods We retrospectively enrolled M1 segment occlusion of middle cerebral artery who underwent emergency magnetic resonance digital subtraction angiography within 24 hours from onset. The extent PVS SWI was assessed using Alberta...
Background: Neuropathic pain is the most common clinical sign of complex regional syndrome (CRPS). Currently, lumbar sympathetic block (LSB) commonly utilized in lower extremity CRPS that has failed to respond medication therapy and physical therapy, but its effectiveness unknown. The tourniquet ischemia test (IT) can distinguish between two types CRPS: IT-positive IT-negative CRPS. Objective: aim study was investigate whether LSB improves scores patients with CRPS-1 screen factors predict...
Abstract Objectives: To investigate the relationship between change of plasma oxidized low-density lipoprotein (oxLDL) level and clinical outcomes in patients with acute atherosclerosis related ischemic stroke. Methods: We recruited stroke within 3 days after onset consecutively. Plasma oxLDL were measured on second day admission before discharge. Initial severity was assessed by National Institutes Health Stroke Scale(NIHSS) scores, infarct volume using diffusion weighted imaging (DWI)...