A5100319715- Nutrition and Health in Aging
- Ovarian function and disorders
- Cancer-related molecular mechanisms research
- Assisted Reproductive Technology and Twin Pregnancy
- Drug-Induced Hepatotoxicity and Protection
- Glaucoma and retinal disorders
- Reproductive Biology and Fertility
- Head and Neck Cancer Studies
- Retinal Diseases and Treatments
- Nephrotoxicity and Medicinal Plants
- Aquaculture disease management and microbiota
- Anesthesia and Pain Management
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Anesthesia and Sedative Agents
- Retinal Imaging and Analysis
- Reproductive System and Pregnancy
- Traditional Chinese Medicine Studies
- Liver physiology and pathology
- Urticaria and Related Conditions
- Aquaculture Nutrition and Growth
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Alzheimer's disease research and treatments
Second Military Medical University
2009-2025
Chengdu University of Traditional Chinese Medicine
2019-2025
Xianyang Normal University
2025
Sichuan University
2022-2024
West China Hospital of Sichuan University
2022-2024
Nanjing University of Aeronautics and Astronautics
2024
Northwest Women's and Children's Hospital
2020-2024
University of Antwerp
2024
Affiliated Hospital of North Sichuan Medical College
2024
Huzhou Central Hospital
2024
Mutations causing a rare skin disease reveal signaling pathway that is drug target for Alzheimer’s disease.
Due to a high rate of nutrient consumption and inadequate vascularization, hepatocellular carcinoma (HCC) cells constantly undergo metabolic stress during tumor development. Hepatitis B virus (HBV) X protein (HBx) has been implicated in the pathogenesis HBV-induced HCC. In this study, we investigated functional roles HBx HCC adaptation stress. Up-regulation increased intracellular ATP NADPH generation, induced resistance glucose deprivation, whereas depletion via siRNA abolished these...
The purpose of this study was to investigate the relationship between sarcopenia index (SI) and stroke risk in elderly patients with hypertension. This included 5145 stroke-free hypertensive patients. We used Cox regression models estimate hazard ratios (HRs) 95% confidence intervals (CIs) incident stroke. Over a median follow-up 38 months, we identified 607 (11.80%) individuals total stroke, whom 507 (9.85%) had ischemic 93 (1.81%) hemorrhagic developing decreased each quartile SI; after...
ABSTRACT This study evaluates the therapeutic impact of Fructus aurantii (FA) stir‐baked with tartary buckwheat bran (TBB) on functional dyspepsia (FD), employing a reserpine at dose 5 mg/kg to rats. FA, traditional Chinese herbal medicine, is processed TBB enhance its gastrointestinal motility benefits. The study's objectives were assess this preparation intestinal flora, SCFA levels, and metabolomic profiles in FD. Rats divided into groups receiving different treatments, TBB‐FA group...
This study investigates the impact of digital transformation on liquidity creation among banks in China, focusing 127 commercial from 2010 to 2021. The research is driven by observed decline real economy function China's financial services recent years. To analyze this trend, employs a panel fixed effect model and an intermediary test model. findings indicate that implementation banking sector resulted significant enhancement generation. transmission pathways through which influences include...
Regorafenib has been approved for second-line treatment of hepatocellular carcinoma (HCC) following sorafenib failure, but resistance to targeted therapy remains a major challenge. Enhancing the therapeutic sensitivity HCC cells regorafenib is crucial improving outcomes. This study aims elucidate role PRMT5 in and its impact on sensitivity. Specifically, it focuses regulatory relationship between RPL14, investigating their influence DNA damage repair drug mechanisms HCC. A stable...
Abstract Recurrence and chemoresistance of liver cancer has been attributed to the existence tumor-initiating cells (T-ICs). It is important decipher molecular mechanism for acquisition drug resistance design combinatorial therapeutic strategies. Cyclin G1 shown play a pivotal role in initiation metastasis hepatocellular carcinoma. In this study, we found that enhanced cyclin expression was associated with hepatoma higher recurrence rate carcinoma patients. Expression elevated T-ICs closely...
Given the growing evidence that sarcopenia is associated with toxicity and survival in various cancers, we investigated its significance patients nasopharyngeal carcinoma (NPC) receiving concurrent chemoradiotherapy (CCRT).In this retrospective analysis, studied 862 NPC who had received CCRT between 2010 2014. Sarcopenia was determined using routine pre-radiotherapy computed tomography (CT) simulation scans at third cervical vertebral level. Receiver-operating characteristic curve analyses...
Despite their central function in tumor immunity, dendritic cells (DCs) can respond to inhibitory signals and become tolerogenic, curtailing T cell responses vivo. Here, we provide the evidence for an of signal regulatory protein (SIRP) α DC survival activation. In tumors from human liver cancer patients, infiltrative DCs expressed elevated levels SIRPα, which is correlated with induction immune tolerance within tumors. Silencing SIRPα resulted a significant increase longevity antigen-pulsed...
Our study aimed to develop and validate an efficient ultrasound image-based radiomic model for determining the Achilles tendinopathy in skiers.
We aimed to investigate the association between GNRI and risk of stroke in elderly patients with hypertension.A total 5312 hypertensive free history were included. Multivariate Cox models used calculate hazard ratios (HRs) their 95% confidence intervals (CIs) for its subtypes.The average time follow-up was 3.8 years, median 3.2 years. identified 640 individuals stroke, whom 526 had an ischemic (IS) 114 a hemorrhagic (HS). After adjusting confounding variables, compared participants lowest...
Abstract Background Ovarian clear cell carcinoma (OCCC) represents a subtype of ovarian epithelial (OEC) known for its limited responsiveness to chemotherapy, and the onset distant metastasis significantly impacts patient prognoses. This study aimed identify potential risk factors contributing occurrence in OCCC. Methods Utilizing Surveillance, Epidemiology, End Results (SEER) database, we identified patients diagnosed with OCCC between 2004 2015. The most influential were selected through...
To compare the diagnostic powers of parameters RTVue and Cirrus-HD optical coherence tomography (OCT) systems in detecting glaucoma highly myopic eyes.For this study, 28 patients with high myopia (HM-G) high-myopia controls (HM-C) were enrolled. The circumpapillary retinal nerve fiber layer (cp-RNFL) ganglion cell complex (GCC) RTVue-OCT, cell-inner plexiform (GCIPL) cp-RNFL Cirrus HD-OCT, obtained for each subject. receiver operating characteristics curve (ROC) was used to assess ability...
Growth hormone (GH) has been proposed as an adjunct in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles, especially women with poor ovarian response. However, it is unclear whether GH supplementation effective embryonic development the previous IVF cycle. The aim of this study was to evaluate effectiveness IVF/ICSI cycles
Background Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with substantial morbidity and mortality. Oxidative stress (OS) has been implicated in the pathogenesis of AF, suggesting that targeting OS-related genes could offer novel therapeutic opportunities. This study aimed to identify causal contributing AF through comprehensive multi-omics Summary-based Mendelian Randomization (SMR) approach. Methods integrated data from genome-wide association studies (GWAS)...