A5101880345- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- Hemophilia Treatment and Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Risk Factors
- Analytical Methods in Pharmaceuticals
- Cancer Immunotherapy and Biomarkers
- Antiplatelet Therapy and Cardiovascular Diseases
- Sepsis Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- Lipid metabolism and disorders
- Reproductive Biology and Fertility
- RNA Research and Splicing
- Bone health and treatments
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Antibiotics Pharmacokinetics and Efficacy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Platelet Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Selenium in Biological Systems
Institute of Animal Sciences
2024-2025
Hubei Academy of Agricultural Sciences
2024-2025
Chengdu Third People's Hospital
2011-2024
Southwest Jiaotong University
2024
ZheJiang Academy of Agricultural Sciences
2024
Zhongnan Hospital of Wuhan University
2017-2024
Wuhan University
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Nanjing University of Chinese Medicine
2024
University of Science and Technology of China
2023
3-methyl-4-nitrophenol (PNMC), a chemical prevalent in various industries for drug, dye, and leather production, also serves as primary byproduct of organophosphate insecticides. Despite its global recognition an endocrine disruptor with documented reproductive toxicity, detrimental impact on preimplantation embryonic development has yet to be thoroughly investigated. In this study, through the vitro culture mice embryos, it was initially observed that even low concentrations PNMC exposure...
Background Cancer, influenced by genetics and the environment, involves anoikis, a cell death mechanism upon extracellular matrix detachment crucial for metastasis. Understanding this relationship is key therapy. We analyze cancer anoikis trends using bibliometrics.
This study aimed to develop a physiologically based pharmacokinetic/pharmacodynamic model (PBPK/PD) of meropenem for critically ill patients. A PBPK in healthy adults was established using PK-Sim software and subsequently extrapolated patients on anatomic physiological parameters. The mean fold error (MFE) geometric (GMFE) methods were used compare the differences between predicted observed values pharmacokinetic parameters C
Brain-derived neurotrophic factor (BDNF) was recently identified as a produced by multiple myeloma (MM) cells, which may contribute to bone resorption and disease progression in MM, though the molecular mechanism of this process is not well understood. The purpose study test effect BDNF on growth MM cells both vitro vivo. Co- triple-culture systems were implemented. results demonstrate that augmented receptor activator nuclear kappa B ligand (RANKL) expression human marrow stromal thus...
Summary Antithrombin (AT) deficiency increases the risk of thrombosis. Current evidence shows that some SERPINC1 mutations responsible for antithrombin often present a slightly decreased or normal activity and therefore could not be detected by functional tests. This study was designed to compare assays direct genetic analyses in identifying hereditary deficiency. In total, 400 consecutive patients with venous thrombosis were enrolled. Functional showed 16 individuals had activity, 14 them...
Autophagy modulation has been considered a potential therapeutic strategy for human chondrosarcoma, and previous study indicated that salidroside exhibits significant anti-carcinogenic activity. However, the ability of to induce autophagy its role in chondrosarcoma cell death remains unclear.We exposed SW1353 cells different concentrations (0.5, 1 2 mM) 24 h. RT-PCR, Western-blotting, Immunocytofluorescence, Luciferase Reporter Assays were used evaluate whether activated TFEB-dependent...
3-methyl-4-nitrophenol (PNMC), a well-known constituent of diesel exhaust particles and degradation products insecticide fenitrothion, is widely distributed environmental contaminant. PNMC toxic to the female reproductive system; however, how it affects meiosis progression in oocytes unknown. In this study, vitro maturation mouse was applied investigate deleterious effects PNMC. We found that exposure significantly compromised oocyte maturation. disturbed spindle stability; specifically,...
// An-Lie Cai 1 , Wei Zeng 1, 2 Wei-Liang Jing-Ling Liu Xue-Wen Zheng Ying Xiang-Cheng Yang Yi Long and Jie Li 3 Department of Orthopedics Surgery, Central Hospital Zhuzhou city The Affiliated Xiangya Medical College South University, Zhuzhou, China Second Changsha, Hunan, Nephrology, City Correspondence to: Zeng, email: zengweixy2yy@163.com Li, yaomaojin@gmail.com Keywords: peroxiredoxin-1; osteosarcoma; metastasis; cell migration Received: August 15, 2017 Accepted: October 28, Published:...
Overexpression of Pokemon, which is an erythroid myeloid ontogenic factor protein, occurs in different cancers, including hepatocellular carcinoma (HCC). Pokemon also reported to have oncogenic activity various human cancers. This study investigated the effect knockdown on regulation HCC growth. POK shRNA suppressed expression protein HepG2 cells compared negative control vector-transfected cells. reduced cell viability and enhanced cisplatin-induced apoptosis AKT activation cycle-related...
Abstract Enoyl coenzyme A hydratase short chain 1 (ECHS1) is an important part of the mitochondrial fatty acid β-oxidation pathway. Altered ECHS1 expression has been implicated in cancer cell proliferation. This study assessed human gastric lines and investigated effects knockdown on proliferation migration. The SGC-7901, BGC-823 MKN-28, immortalized epithelial mucosa GES-1 line were analyzed for protein levels using western blot. effectiveness ECHS1-RNA interference was also determined...
The aim of this study is to determine the patterns mortality from cardiac-cerebral vascular disease (CCVD) and how they relate cosmophysical factors over a six-year span. daily number deaths recorded in Chengdu 2192 consecutive days (2007–2012), together with several related solar activity (SA), geomagnetic (GMA), interplanetary magnetic field, were analyzed by extended cosinor estimate parameters major cycles characterizing each variable. Estimates their respective periods measure...
Plasma levels of the anticoagulant cofactor protein S and PROS1 mutation are reported to impart increased risk thromboembolism in European south east Asian populations, but relationship is not yet documented Han Chinese population-based study. Therefore, we undertook a case-control study this among patients with venous thromboembolism, probed genetic factors contributing low deficiency. Among 603 consecutively recruited patients, 51 (8.5%) proved be deficient free antigen (lower than 38.6...
: It is still controversial to employ osimertinib as the first-line therapy for EGFR-mutated non-small cell lung cancer (NSCLC) patients in practice. The aim of current study was explore risk factors acquired T790M mutation during EGFR-TKIs therapy, and identify potential most likely benefit from treatment.
Hemophilia B (HB) is an X-linked recessive bleeding disorder caused by mutations in the coagulation factor IX (FIX) gene. Genotyping patients with HB essential for genetic counseling and provides useful information patient management. In this study, F9 gene from 23 was analyzed direct sequencing. Nineteen point were identified, including a novel missense variant (c.520G > C, p.Val174Leu) severe previously unreported homozygous mutation (c.571C T, p.Arg191Cys) female mild HB. Two large...
<ns4:p>The genetic background of ischemic vascular disease is actively being explored. Several studies have shown that inhibition <ns4:italic>APOC3</ns4:italic> significantly reduces plasma levels apolipoprotein C3 and triglycerides. Recently, the TG HDL Working Group Jørgensen <ns4:italic>et al.</ns4:italic> reported loss-of-function mutations in are associated with decreased triglyceride a reduced risk European African individuals. We performed replication study 4470 Chinese participants....