A5102765753- Vanadium and Halogenation Chemistry
- Heme Oxygenase-1 and Carbon Monoxide
- Epigenetics and DNA Methylation
- COVID-19 Clinical Research Studies
- Cancer, Hypoxia, and Metabolism
- SARS-CoV-2 detection and testing
- Cytokine Signaling Pathways and Interactions
- Liver physiology and pathology
- RNA modifications and cancer
- RNA Research and Splicing
- Immune Response and Inflammation
- Tuberculosis Research and Epidemiology
- Fibroblast Growth Factor Research
- Ferroptosis and cancer prognosis
- Nitric Oxide and Endothelin Effects
- Cancer-related Molecular Pathways
- Metal-Catalyzed Oxygenation Mechanisms
- NF-κB Signaling Pathways
- Liver Disease Diagnosis and Treatment
Xiangya Hospital Central South University
2024-2025
Central South University
2024-2025
Massachusetts General Hospital
2011
Peking University
2008-2010
Nasopharyngeal carcinoma (NPC) is a malignant tumor that highly prevalent in Southeast Asia, especially South China. The pathogenesis of NPC complex, and genetic alterations suppressors proto-oncogenes play important roles carcinogenesis. p53 unexpectedly expressed possesses an uncommon mutation R280T, which different from high frequency hotspot mutations or low expression other tumors. However, the mechanism loss function its correlation with R280T are still unclear. In this study, amyloid...
Abstract Fibroblast growth factor receptor (FGFR) inhibitors are emerged as an important class of targeted therapies in oncology, targeting key pathways associated with tumor growth, angiogenesis, and resistance to conventional treatments. FIIN‐2, the first irreversible covalent pan‐FGFR inhibitor, has shown promise overcoming due gatekeeper mutations; however, its selectivity molecular mechanisms tumors remain poorly understood. In this study, FIIN‐2 chemical probe is designed synthesized...
Lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF)-α requires the recruitment two pairs adaptors to Toll-like receptor 4 cytoplasmic domain. The contribution one pair – Toll-interleukin-1 domain-containing adaptor inducing interferon-β (TRIF) and TRIF-related molecule (TRAM) TNF-α expression is not well understood. To clarify this issue, we studied TRAM knockout bone marrow-derived macrophages (BMDM). LPS-stimulated TRAM-deficient BMDM had decreased protein even at...
At present, the epidemic situation of coronavirus disease 2019 (COVID-19) in world is still a very serious problem, rapid and accurate diagnosis COVID-19 patients great significance for prevention control. The investigation process patient with were summarized present study, to provide valuable information clinical or was migrant work⁃ er who went Chongqing returned his hometown Jan. 23, 2020. During stay Chongqing, one patient’s col⁃ leagues after he back Ziyang from eight other colleagues...