A5101915763- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- HER2/EGFR in Cancer Research
- Biochemical and Structural Characterization
- Immunotherapy and Immune Responses
- Microbial Metabolites in Food Biotechnology
- Biofuel production and bioconversion
- Fungal Plant Pathogen Control
- Enzyme Production and Characterization
- Plant Virus Research Studies
- Plant-Microbe Interactions and Immunity
- Cell death mechanisms and regulation
- Essential Oils and Antimicrobial Activity
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Viral Infectious Diseases and Gene Expression in Insects
- Antimicrobial Peptides and Activities
- Phytochemical compounds biological activities
- Endoplasmic Reticulum Stress and Disease
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
China International Science and Technology Cooperation
2025
Zhejiang Chinese Medical University
2025
People's Liberation Army 401 Hospital
2024
Soochow University
2024
Zhejiang Lab
2021-2024
Zhejiang University
2015-2024
Affiliated Hospital of Hangzhou Normal University
2022-2023
Huazhong University of Science and Technology
2013-2023
Lanzhou University
2016-2023
Wuhan No.1 Hospital
2020-2023
Chimeric antigen receptor T (CAR-T) cell therapy is a promising and precise targeted for cancer that has demonstrated notable potential in clinical applications. However, severe adverse effects limit the application of this are mainly caused by uncontrollable activation CAR-T cells, including excessive immune response due to unregulated action time, as well toxicity resulting from improper spatial localization. Therefore, enhance controllability safety, control module cells proposed....
Abstract Bystander‐killing payloads can significantly overcome the tumor heterogeneity issue and enhance clinical potential of antibody‐drug conjugates (ADC), but rational design identification effective bystander warheads constrain broader implementation this strategy. Here, graph attention networks (GAT) are constructed for a killing scoring model ADC construction workflow first time. To generate efficient bystander‐killing payloads, is utilized score‐directed exatecan derivatives design....
Probiotics have been widely explored in production, research, environmental protection, and disease prevention. Recent efforts devoted to the separation of new probiotics from microbes that never discovered research their mechanism action. PBDB, it is a database collects different fermented foods. It has established collected 1730 known (768 264 22 17 control, 659 others) providing biological information for use humans, animals, plants. The will be updated expanded periodically. can provide...
Purpose: Acute myocardial infarction (AMI) is a major contributor to death. The purpose of this study explore circulating biomarkers for AMI diagnosis from the perspectives immunological microenvironment and N6-methyladenosine (m6A) RNA methylation regulation. Patients Methods: GSE59867 dataset was used download platform probe data conducting differential analysis m6A regulators. A diagnostic nomogram created utilizing random-forest method evaluated predictive power. m6A-related gene...
The etiology of osteoarthritis (OA) is complex and multifaceted. Osteoarthritis a chronic progressive disease the joints that characterized by degradation articular cartilage. A disintegrin metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) major aggrecanase in aim this study was to evaluate effect ADAMTS-5 knockdown on cartilage degradation. Rat chondrocytes were transfected lentivirus‑mediated small interfering RNA (siRNA) or empty vector control plasmid DNA (as control)....
Although the global pandemic of SARS-CoV-2 has passed, there are still regional outbreaks that continue to jeopardize human health. Hence, is a great deal interest in developing an efficient vaccine can quickly and effectively prevent reemerging SARS-CoV-2. Delta variant was once dominant strain world 2021, we first constructed recombinant RBDdelta-Fc fusion by coupling RBD with Fc fragment. This strategy increases immunogenicity vaccine, long-lasting high level IgG antibodies neutralizing...
Antibody-drug conjugate (ADC) targeting antigens expressed on the surface of tumor cells are an effective approach for delivering drugs into via antigen-mediated endocytosis. One well-known antigens, CD20 B-lymphocyte, has long been suggested to be noninternalizing epitope, and is thus not considered a desirable target ADCs. Here, sortase A (srtA)-mediated transpeptidation used specifically triple glycine-modified monomethyl auristatin E (MMAE), highly toxic antimitotic agent, anti-CD20...
Humulus lupulus Linn. is a traditional medicinal and edible plant with several biological properties. The aims of this work were: (1) to evaluate the in vitro antifungal activity H. ethanolic extract; (2) study vivo isoxanthohumol, an isoprene flavonoid from lupulus, against Botrytis cinerea; (3) explore mechanism isoxanthohumol on B. cinerea. present data revealed that extract exhibited moderate five tested phytopathogenic fungi vitro, showed highly significant cinerea, EC50 value 4.32...
Non-alcoholic fatty liver disease (NAFLD) is closely related to cardiovascular diseases (CVD). A newly proposed definition metabolic dysfunction-associated (MAFLD), which was changed from NAFLD. The clinical effect of this change on abnormalities cardiac structure and function yet unknown. We aimed examine whether MAFLD associated with left ventricular (LV) diastolic dysfunction (LVDD) remolding further identify the impact different subgroups severity MAFLD.We evaluated 228 participants...
The inhibitory effect of tavaborole on the invasion Botrytis cinerea in grapes and tomatoes, as well potential mechanism involved, was discovered this study. Our findings showed that inhibited spore germination mycelial expansion vitro control efficiency vivo fruit decay dose-dependent, which effective reducing disease severity maintaining organoleptic quality fruit, such weight loss retaining hardness titratable acid contents during storage. Furthermore, precise action investigated further....
The increasing resistance of plant diseases caused by phytopathogenic fungi highlights the need for highly effective and environmentally benign agents. antifungal activities Cnidium monnieri fruit extracts five isolated compounds as well structurally related coumarins against pathogenic were evaluated. acetone extract, which contained highest amount coumarins, showed strongest activity. Among coumarin compounds, we found that 4-methoxycoumarin exhibited stronger broader activity fungi, was...
Cancer is one of the most lethal diseases all over world. Despite that many drugs have been developed for cancer therapy, they still suffer from various limitations including poor treating efficacy, toxicity to normal human cells, and emergence multidrug resistance. In this study, amphiphilic LHES polymers were prepared using hydroxyethyl starch (HES) linoleic acid as starting materials. The content substitution degree groups in analyzed. used fabricating LHES-B nanoparticles carrying a...
The novel coronavirus pneumonia (COVID-19) pandemic is a great threat to human society and now still spreading. Although several vaccines have been authorized for emergency use, only one recombinant subunit vaccine has permitted widespread use. More COVID-19 should be developed in the future. receptor binding domain (RBD), located at S protein of SARS-CoV-2, contains most neutralizing epitopes. However, immunogenicity RBD monomers not strong enough. In this study, we fused RBD-monomer with...
Gastrodiae Rhizoma and its active constituents are known to exhibit neuroprotective effects in Alzheimer’s disease (AD). However, the effect of water extract (WERG) on AD detailed mechanism action remain unclear. In this study, WERG was investigated by microbiome–gut–brain axis using a D-galactose (D-gal)/AlCl 3 -induced mouse model. improved cognitive impairment D-gal/AlCl mice. The expression level p-Tau thr231 WERG-H treatment group decreased, found negative hippocampal DG, CA1, CA3...