A5100651017- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Plant-Microbe Interactions and Immunity
- Essential Oils and Antimicrobial Activity
- Infective Endocarditis Diagnosis and Management
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Protein Degradation and Inhibitors
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Advanced Breast Cancer Therapies
- Cardiovascular Disease and Adiposity
- Synthesis and biological activity
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Histone Deacetylase Inhibitors Research
- Fungal Plant Pathogen Control
State Key Laboratory of Plant Genomics
2025
Chinese Academy of Sciences
2025
Tianjin Children's Hospital
2025
Tianjin University
2025
Beihua University
2024-2025
Peking University Third Hospital
2022-2024
Peking University
2022-2024
Fudan University
2023-2024
Huashan Hospital
2023-2024
Yangzhou University
2024
Abstract Background The relationship between triglyceride-glucose index (TyG index) and the prevalence prognosis of cardiovascular disease has been confirmed by former studies. However, it remains uncertain whether TyG a prognostic impact in patients with type 2 diabetes mellitus (T2DM) non-ST-segment elevation acute coronary syndrome (NSTE-ACS) undergoing percutaneous intervention (PCI). Methods study retrospectively enrolled 798 (mean age: 60.9 ± 8.3 years; 68.3% men) T2DM NSTE-ACS who...
The triglyceride-glucose index (TyG index) is proposed as a surrogate parameter for insulin resistance (IR) and, when elevated, related to increased cardiovascular risks. Whether the TyG of great value in predicting adverse prognosis individuals diagnosed with non-ST-segment elevation acute coronary syndrome (NSTE-ACS), who received elective percutaneous intervention (PCI), and without recognized diabetes remains unclear.
The microRNA-26 (miR-26) family is known to control adipogenesis in non-ruminants. genomic loci of miR-26a and miR-26b have been localized the introns genes encoding for proteins C-terminal domain RNA polymerase II polypeptide A small phosphatase (CTDSP) family. Insulin-induced gene 1 (INSIG1) encodes a protein with key role regulation lipogenesis rodent liver. In present study, we investigated synergistic function miR-26 their host goat mammary epithelial cells (GMEC). Downregulation...
Background: Intraplaque angiogenesis, the process of generating new blood vessels mediated by endothelial cells, contributes to plaque growth, intraplaque hemorrhage, and thromboembolic events. Platelet-derived Exosomes (PLT-EXOs) affect angiogenesis in multiple ways. The ability miR-126, one best-characterized miRNAs that regulates carried PLT-EXOs influence via regulation proliferation migration cells is unknown. In this study, we aimed investigate effects on Human Umbilical Vein...
Abstract Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis due to M. (Mtb), which kills millions of people each year. variably protects children, but not adults tuberculosis. evades phagosome maturation, autophagy, and reduces MHC-II expression antigen-presenting cells (APCs) affecting T-cell activation. To bypass these defects, an autophagy-inducing, TLR-2 activating C5 peptide from Mtb-derived CFP-10 protein was overexpressed in combination with Ag85B. Recombinant...
The cell death pathway, including apoptosis, autophagy, and necroptosis, plays an essential role in hepatocellular carcinoma (HCC) progression outcome. However, the integration of three pathways into a prognostic signature has not yet been reported HCC. This study aimed to investigate association among death-related genes (CDRGs), prognosis, immune microenvironment, checkpoint. RNA expression profiles corresponding clinical data HCC were retrieved from Cancer Genome Atlas (TCGA), Gene...
Metabolic dysfunction-associated steatohepatitis (MASH) is a significant risk factor for gallstone formation, but mechanisms underlying MASH-related formation remain unclear. Golgi membrane protein 1 (GOLM1) participates in hepatic cholesterol metabolism and upregulated MASH. Here, we aimed to explore the role of GOLM1 formation.
Prolactin is an important endocrine activator of lactogenesis. This study investigated the function and mechanism miR-135b in enhancement lactation by prolactin goat mammary epithelial tissue. We utilized S-Poly (T) sequencing to evaluate changes gene regulation gland after incubation with 2.5 μg/ml IGF-1 examining highly expressed miRNAs during early late-lactation. The results illustrated that late-lactation, also treatment IGF-1. used Q-RT PCR, Western Blot, immunofluorescence, luciferase...
The inhibitory effect of tavaborole on the invasion Botrytis cinerea in grapes and tomatoes, as well potential mechanism involved, was discovered this study. Our findings showed that inhibited spore germination mycelial expansion vitro control efficiency vivo fruit decay dose-dependent, which effective reducing disease severity maintaining organoleptic quality fruit, such weight loss retaining hardness titratable acid contents during storage. Furthermore, precise action investigated further....
Background: Use of dilute epinephrine tumescent solution in breast reduction surgery has been shown to significantly decrease operative blood loss without increasing perioperative complications. Lidocaine is commonly added postoperative pain. Evidence supporting this practice, however, limited, and lidocaine toxicity reported. Methods: With institutional review board approval, patients undergoing bilateral were assigned receive either saline with (1:1 million) (group 1), or (0.05%) 2)....
Background and objective: Contrast-induced acute kidney injury (CI-AKI) is a serious complication of the administration iodinated contrast media (CM) for diagnostic interventional cardiovascular procedures associated with substantial morbidity mortality. While preventative measures can mitigate risk CI-AKI, there remains need novel effective therapeutic approaches. The pathogenesis CI-AKI complex not completely understood. CM-induced renal tubular cell apoptosis caused by activation...
Abstract Acute myocardial infarction (AMI) remains one of the leading causes morbidity and mortality worldwide. Ischemia/reperfusion (I/R), most common consequence AMI treatment, may induce severe cell injury, yet precise mechanism continues to be enigmatic. In present study, we found that miR‐129‐5p was significantly downregulated in mouse I/R model. Then, overexpressed via intravenous injection specific agomir before model establishment. MiR‐129‐5p overexpression dramatically alleviated...
Abstract Background It is uncertain whether estimated remnant-like particle cholesterol (RLP-C) could predict residual risk in patients with different glycometabolic status. This study aimed to evaluate the relationship between RLP-C and adverse prognosis non-ST-segment elevation acute coronary syndrome (NSTE-ACS) treated percutaneous intervention (PCI) identify potential impact of glycometabolism on predictive value RLP-C. Methods The assessed 2419 participants NSTE-ACS undergoing PCI at...
The chemical composition, antioxidant, antibacterial and cholinesterase inhibitory activities of three Juniperus species were studied. contents total phenolic 10 compounds highest in rigida Sieb.et Zucc., which catechin cumaric acid the predominant compounds, but lowest sibirica Burgsd. GC-MS analysis showed essential oils J. (92.61%), followed by formosana Hayata (87.30%) (84.89%). a-pinene was most dominant compound (23.99%) (9.71%), however, it has not been detected sibirica. Ethanol...
EGF acts as a ligand of the receptor (EGFR) to activate EGFR-mediated signaling pathways and is involved in regulation cell physiology. However, roles EGFR mediated lipid metabolism goat mammary epithelial cells (GMECs) are poorly understood. To evaluate impact on GMECs, triglyceride (TG) content droplet were detected, using TG assay immunofluorescence. Further, expression lipogenic genes, protein kinase B (Akt), phospholipase C-γ1 (PLC-γ1) extracellular signal-regulated kinases (ERK)1/2...