A5103108406- Plant Molecular Biology Research
- Light effects on plants
- Photosynthetic Processes and Mechanisms
- Plant nutrient uptake and metabolism
- Fungal Plant Pathogen Control
- Plant Stress Responses and Tolerance
- Synthesis and Biological Evaluation
- Synthesis and bioactivity of alkaloids
- Plant Gene Expression Analysis
- Plant Disease Resistance and Genetics
- Toxin Mechanisms and Immunotoxins
- Synthesis and biological activity
- Greenhouse Technology and Climate Control
- Fermentation and Sensory Analysis
- Quinazolinone synthesis and applications
- Boron and Carbon Nanomaterials Research
- Essential Oils and Antimicrobial Activity
- Circular RNAs in diseases
- Magnolia and Illicium research
- Autophagy in Disease and Therapy
- Effects of Radiation Exposure
- Extracellular vesicles in disease
- Pediatric health and respiratory diseases
- Aluminum toxicity and tolerance in plants and animals
- Thallium and Germanium Studies
Southern Medical University
2025
Guangdong Provincial People's Hospital
2025
Guangdong Academy of Medical Sciences
2025
Zunyi Medical University
2024
Lanzhou University
2020-2023
Tobacco Research Institute
2021-2023
Chinese Academy of Agricultural Sciences
2021-2023
Ministry of Agriculture and Rural Affairs
2021-2022
Fudan University
2016-2021
First Affiliated Hospital of Henan University of Science and Technology
2021
Cryptochromes (CRYs) are blue light photoreceptors that mediate a variety of responses in plants and animals, including photomorphogenesis, flowering, circadian rhythms. The signaling mechanism by which Arabidopsis thaliana cryptochromes CRY1 CRY2 promote photomorphogenesis involves direct interactions with COP1, RING motif-containing E3 ubiquitin ligase, its enhancer SPA1. Brassinosteroid (BR) is key phytohormone involved the repression here, we show inhibition BR signaling. physically...
Arabidopsis CRY1 and phyB are the primary blue red light photoreceptors mediating inhibition of hypocotyl elongation, respectively. Auxin is a pivotal phytohormone involved in promoting elongation. interact with stabilize auxin/indole acetic acid proteins (Aux/IAAs) to inhibit auxin signaling. The present study investigated whether might directly Response Factors (ARFs) regulate Protein-protein interaction studies demonstrated that physically ARF6 ARF8 through their N-terminal domains...
Proper timing of flowering is essential for reproduction plants. Although it well known that both light and gibberellin (GA) signaling play critical roles in promoting Arabidopsis thaliana, whether how they are integrated to regulate remain largely unknown. Here, we show through biochemical studies DELLA proteins physically interact with CONSTANS (CO). Furthermore, the interaction CO NF-YB2 inhibited by protein, RGA. Our findings suggest regulation GA leaves under long days mediated, at...
Abstract Cryptochromes are blue light photoreceptors that mediate various responses in plants and mammals. In Arabidopsis (Arabidopsis thaliana), cryptochrome 1 (CRY1) mediates light-induced photomorphogenesis, which is characterized by reduced hypocotyl elongation enhanced anthocyanin production, whereas gibberellin (GA) signaling mediated the GA receptor GA-INSENSITIVE DWARF1 (GID1) DELLA proteins promotes inhibits accumulation. Whether CRY1 control of photomorphogenesis involves...
Cryptochromes are photolyase-like, blue-light (BL) photoreceptors found in various organisms. Arabidopsis (Arabidopsis thaliana) cryptochromes (CRYs; CRY1, and CRY2) mediate many light responses including photoperiodic floral initiation. interact with COP1 SPA1, causing the stabilization of CONSTANS (CO) promotion FLOWERING LOCUS T (FT) transcription flowering. The AP2-like transcriptional factor TOE1 negatively regulates FT expression flowering by indirectly inhibiting CO activation...
Enlightened from our previous work of structural simplification quinine and innovative application natural products against phytopathogenic fungi, lead structure 2,8-bis(trifluoromethyl)-4-quinolinol (3) was selected to be a candidate its diversified design, synthesis, antifungal evaluation were carried out. All the synthesized compounds Aa1-Db1 evaluated for their activity four agriculturally important Botrytis cinerea, Fusarium graminearum, Rhizoctonia solani, Sclerotinia sclerotiorum....
This study aims to identify the periodontitis factor that activates excessive autophagy in pancreatic β cells, resulting organic lesions of islet tissues and diminished insulin secretion, thereby accelerating progression diabetes mellitus (DM).
Programmed cell death (PCD) modulated radioresistance is one of the predominant causes treatment failure in glioblastoma (GBM). Disulfidptosis, a newly discovered form PCD, plays crucial role GBM progression. However, association among disulfidptosis, radiosensitivity and radiotherapy (RT) remain unclear. We systematically analyzed disulfidptosis-related genes 1075 patients constructed gene signature (DRS). Correlations DRS, patient prognosis immune microenvironment were fully explored. The...
Based on the structural characteristics of cryptolepine alkaloid, a series new quindoline derivatives bearing various substituents were prepared and evaluated for their fungicidal antibacterial activities. Bioassay results showed that compound D7 displayed superior in vitro activities against Sclerotinia sclerotiorum, Botrytis cinerea, Fusarium graminearum, Rhizoctonia solani with EC50 values 0.780, 3.62, 1.59, 2.85 μg/mL, respectively. Compound A7 apparent toward Xanthomonas oryzaepv....
Sucrose (Suc) accumulation is one of the key indicators leaf senescence onset, but little known about its regulatory role. Here, we found that application high (120–150 mM) and low levels (60 Suc to young (YL) fully expanded (FEL) discs, respectively, decreased chlorophyll content maximum photosynthetic efficiency. Electrolyte leakage malondialdehyde increased at concentrations (90–120 mM in YL 60 150 FEL discs). In senescence-associated gene NtSAG12 showed a gradual increase expression with...
Humulus lupulus Linn. is a traditional medicinal and edible plant with several biological properties. The aims of this work were: (1) to evaluate the in vitro antifungal activity H. ethanolic extract; (2) study vivo isoxanthohumol, an isoprene flavonoid from lupulus, against Botrytis cinerea; (3) explore mechanism isoxanthohumol on B. cinerea. present data revealed that extract exhibited moderate five tested phytopathogenic fungi vitro, showed highly significant cinerea, EC50 value 4.32...
Arabidopsis cryptochrome 1 (CRY1) is an important blue light photoreceptor that promotes photomorphogenesis under light. The photoreceptors CRY2 and phototropin 1, the red/far-red phytochromes B A undergo degradation in response to red light, respectively. This study investigated whether how CRY1 might high-intensity (HBL). We demonstrated ubiquitinated degraded through 26S proteasome pathway HBL. found E3 ubiquitin ligase constitutive photomorphogenic (COP1) involved mediating HBL-induced...
Crop diseases caused by fungi threaten food security and exacerbate the crisis. Inspired application of fungicide candidates from natural products in agrochemical discovery, a series luotonin A derivatives were designed, synthesized, evaluated for their antifungal activities against five plant fungi. Most these compounds exhibited significant fungicidal activity Botrytis cinereain vitro with EC50 values less than 1 μg/mL. Among them, w7, w8, w12, w15 showed superior B. cinerea 0.036, 0.050,...
The unreasonable use of chemical fungicides causes common adverse consequences that not only affect the environment, but also cause resistance and resurgence problems plant pathogens, which are extremely harmful to human health, economy, environment. Based on rich biological activities boron-based compounds, 82 phenylboronic acid derivatives were selected their antifungal against six agricultural pathogens determined. Combined with transcriptomics tools, mechanism action compound A49...
The increasing resistance of plant diseases caused by phytopathogenic fungi highlights the need for highly effective and environmentally benign agents. antifungal activities Cnidium monnieri fruit extracts five isolated compounds as well structurally related coumarins against pathogenic were evaluated. acetone extract, which contained highest amount coumarins, showed strongest activity. Among coumarin compounds, we found that 4-methoxycoumarin exhibited stronger broader activity fungi, was...
Rhizoctonia solani causes serious plant diseases. Neocryptolepine presented the significant antifungal activity against R. solani, however mode of action is unclear. In this paper, we investigated potential neocryptolepine integrated proteomics and transcriptomics. Results showed that after treatment with neocryptolepine, 1012 differentially expressed proteins 10 920 genes were found, most them enriched in mitochondrial respiratory chain. It affected oxidative phosphorylation led to...
Tumor-derived exosomes (exo) could modulate the biological behaviors of human umbilical vein endothelial cells (HUVECs). Here, role microRNA (miR)-10a-5p-modified gastric cancer (GC) cells-derived exo for HUVECs was studied. GC tissue specimens were collected, and miR-10a-5p zinc finger MYND-type containing 11 (ZMYND11) levels determined. interfered with ZMYND11 or miR-10a-5p-related oligonucleotides. Exo extracted from (HGC-27 exo), mimic-modified HGC-27 co-cultured HUVECs. viability,...