A5071248579- Mesenchymal stem cell research
- Nerve injury and regeneration
- Oral microbiology and periodontitis research
- Cell Adhesion Molecules Research
- Periodontal Regeneration and Treatments
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Advanced Glycation End Products research
- Virus-based gene therapy research
- Cytokine Signaling Pathways and Interactions
- Maternal and fetal healthcare
- Reproductive System and Pregnancy
- Ginkgo biloba and Cashew Applications
- Calcium signaling and nucleotide metabolism
- Salivary Gland Disorders and Functions
- Wnt/β-catenin signaling in development and cancer
- Pluripotent Stem Cells Research
- Bone and Dental Protein Studies
- Bioactive natural compounds
- Anesthesia and Neurotoxicity Research
- Inflammatory Bowel Disease
Zunyi Medical University
2015-2025
Stomatology Hospital
2019-2025
Zigong First People's Hospital
2024
British Society of Periodontology
2024
Jiangsu University
2024
Fourth People's Hospital of Liaocheng
2018
Army Medical University
2016
Daping Hospital
2016
This study aims to identify the periodontitis factor that activates excessive autophagy in pancreatic β cells, resulting organic lesions of islet tissues and diminished insulin secretion, thereby accelerating progression diabetes mellitus (DM).
Abstract Multiple studies have shown that diabetes mellitus is an established risk factor for periodontitis. Recently mesenchymal stem cells derived from periodontal ligament (PDLSCs) been utilized to reconstruct tissues destroyed by chronic inflammation. However, impact of periodontitis with on PDLSCs and mechanisms mediating effects complex microenvironments remain poorly understood. In this study, we found multiple differentiation potential donors (D-PDLSCs) was damaged significantly....
Bone morphogenetic protein 9 (BMP9) and nerve growth factor (NGF) are critical factors influencing osteogenic differentiation in mesenchymal stem cells (MSCs). While BMP9 has been recognized for its potent capabilities, NGF's role bone tissue engineering is less understood. This investigation delineated the synergistic link of with NGF driving C3H10T1/2 MSCs. To evaluate combined impact on markers' expression levels formation calcified nodules cells, providing a basis enhanced regeneration...
Abstract Considerable evidence has shown that the Wnt/β-catenin pathway is involved in osteogenic differentiation various stem cells. However, role of regulating rat ectomesenchymal cells (EMSCs), which are considered to be progenitors dental mesenchymal cells, remains unknown. In this study, we demonstrated nuclear β-catenin was upregulated during EMSC differentiation. The Wnt signalling inhibitor IWR-1-endo inhibited differentiation, while agonist SKL2001 promoted it. Moreover, further by...
Recent studies have confirmed the bidirectional relationship between two and exacerbation of periodontitis by type II diabetes mellitus (T2DM), pathogenic mechanism has not yet been clarified, AGEs linked to pathogenesis both T2DM, JNK signaling pathway might play a important role explain inner mechanism.To study advanced glycation end products (AGEs) activate innate immune system host activating oxidative stress affecting cellular signal transduction in periodontal ligament stem cells...
Abstract Objectives The aim of this study was to investigate the role p75 neurotrophin receptor (p75NTR) in regulating mouse alveolar bone development and mineralization potential murine ectomesenchymal stem cells (EMSCs). Moreover, we tried explore underlying mechanisms associated with PI3K/Akt/β‐catenin pathway. Materials methods p75NTR knockout (p75NTR −/− ) mice wild‐type (WT) littermates were used. E12.5d WT EMSCs isolated same pregnant ‐/+ from embryonic maxillofacial processes...
The two-child policy implemented in China resulted a surge of high-risk pregnancies among advanced maternal aged women and presented window opportunity to identify large number placenta accreta spectrum (PAS) cases, which often invoke severe blood loss hysterectomy. We thus had an evaluate the surgical outcomes unique conservative PAS management strategy for uterus preservation, impacts magnetic resonance imaging (MRI) planning.Cross-sectional study, comparing new uterine artery ligation...
Abstract Objectives The aim of this study was to investigate whether p75 NTR (p75 neurotrophin receptor) regulates differential mineralization capacity rEMSC s (rat ectomesenchymal stem cells) and underlying mechanisms associated with Mage‐D1 (melanoma‐associated antigens‐D1). Materials methods Immunohistochemical staining in developing tooth germs performed on E12.5d (embryonic 12.5 days) E19.5d 19.5 days). EMSC were isolated the same pregnant Sprague‐Dawley rats from embryonic...
Abstract Objectives The aim of this study was to investigate whether sclerostin ( SOST ) regulates the osteogenic differentiation rat ectomesenchymal stem cells EMSC s) and low‐affinity nerve growth factor receptor LNGFR regulate s. Materials methods s were isolated from embryonic facial processes an 12.5‐day (E12.5d) pregnant Sprague‐Dawley rat. + − obtained by fluorescence‐activated cell sorting subsequently induced undergo in vitro. / small‐interfering RNA overexpression plasmids used...
Effects of compound Danshen injection combined with magnesium sulfate on serum myeloperoxidase (MPO) and hypersensitive C-reactive protein (hs-CRP) in patients severe preeclampsia (PE) were investigated. Five hundred PE randomly divided into early-onset observation, control, late-onset observation control groups. Control group was treated sulfate, while injection. Serum levels MPO hs-CRP measured by enzyme-linked immunosorbent assay (ELISA) turbidimetric assay. The effects the above indexes...
The craniofacial skeleton is the foundation of most stomatological treatments, including prosthodontics and maxillofacial surgery. Although histologically similar to appendicular skeleton, manifests many unique properties in response external stimuli signals. However, mandibular or maxillary bone marrow mesenchyme, which intrinsic functions has not been well studied, its homeostasis mechanism remains elusive. Osteoporosis a systemic disease that affects all skeletons characterized by mass...
Abstract Human periodontal ligament stem cells (hPDLSCs) are a promising source in regenerative medicine. Due to the complexity and heterogeneity of hPDLSCs, it is critical isolate homogeneous hPDLSCs with high potential. In this study, p75 neurotrophin receptor (p75NTR) was used p75NTR + − by fluorescence‐activated cell sorting. Differences osteogenic differentiation among , unsorted were observed. Differential gene expression profiles between analysed RNA sequencing. α1 Integrin (ITGA1)...
Objective: To investigate the effect of miR-705 on osteogenic differentiation mouse embryo osteoblast precursor (MC3T3-E1) cells. Methods: mimics, inhibitors and negative control were transfected into MC3T3-E1 Alkaline phosphates (ALP) staining performed quantified after 7 days medium induction. The mRNA protein expression levels runt-related transcription factor 2 (Runx2) osteocalcin (OCN) detected by real-time RT-PCR Western blot 14 Alizarin red was in cells 21 Results: After induction,...
To investigate the mineralized capacities of ectomesenchymal stem cells (EMSC) from facial process Sprague Dawley(SD) rat embryo different age in vitro and expression p75 neurotrophin receptor(p75NTR) this process.The cell surface antigens EMSC 12.5 d, 15.5 d 18.5 SD embryonic were tested by flow cytometry technology. E12.5 EMSC, E15.5 E18.5 incubated under mineralization induction analysed alkaline phosphatase(ALP) staining on day 7(d7) alizarin red 21(d21). Expression changes Runt-related...
This study aims to explore the status quo of health literacy and quality life in elderly patients with chronic periodontitis determine their correlation understand influencing factors life.