Abstract In the present work, we constructed nanoscale graphene oxide (NGO) as a drug nanocarrier to improve process of tumor-targeted releases, promote cellular uptake and accumulation chemotherapy drugs in tumor tissues, reduce toxic effects on normal cells. Hence, great stability was obtained biological solution. Moreover, designed an effective nanoparticle system for doxorubicin (DOX) delivery targeting oral squamous cell carcinoma (OSCC) by mediating HN-1 (TSPLNIHNGQKL) through hydrogen...

Abstract As a natural “binder,” lignin fixes cellulose in plants to foster growth and longevity. However, isolated has poor binding ability, which limits its biomedical applications. In this study, inspired by mussel adhesive proteins, acidic/basic amino acids (AAs) are introduced alkali (AL) form ionic‐π/spatial correlation interactions, followed demethylation create catechol residues for enhanced adhesion activity. Atomic force microscopy reveals that the primary structures, with basic AAs...

Background: Cancer is the biggest killer that threatens human health. Poor bioavailabil-ity and strong drug resistance of cancer drugs are common defects. In recent years, delivery therapy based on nanotechnology has become a focused research area, nano sys-tem been widely studied in treatment. Objective: Based articles patents published application systems treatment past five this paper summarizes types their advantages limitations order to provide reference for future anticancer systems....

This study focuses on the preparation of a highly active surface-enhanced Raman spectroscopy (SERS) substrate, where Ag nanoparticles synthesized by Lee–Meisel method are loaded onto surface GO@PVP through classical electrostatic attraction. The substrate was characterized SEM and XPS analysis. SERS-active utilized for detection phenanthrene in aqueous solutions, achieving limit 10−8 g/L (5.6 × 10−11 mol/L). In comparison to conventional spectroscopy, this exhibits significant reduction...

Typha angustifolia L. is a perennial marsh botanical drugs belonging to the genus of family Typhaceae, boasts medicinal legacy spanning over 1900 years in China. Within traditional medicine, it often used treat variety bleeding disorders and gynecological diseases. contains various active components metabolites including flavonoids, steroids, phenylpropanoids organic acids. Over 94 compounds have been isolated identified from T. , demonstrating significant pharmacological activities such as...

A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with controlled release of tannic acid (TA) was synthesized using chitosan (CS). Specifically, the photo-crosslinked CS first obtained then immersed in TA solution to generate composite enhanced mechanical properties. Subsequently, N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl) carbodiimide based coupling chemistry used covalently crosslink glucose oxidase (GOx) obtain sensitivity. The physicochemical properties,...

Macrophage-mediated bone immune responses significantly influence the repair of defects when utilizing tissue-engineered scaffolds. Notably, scaffolds' physical structure critically impacts macrophage polarization. The optimal pore size for facilitating remains a topic debate due to imprecision traditional methods in controlling scaffold dimensions and spatial architecture. In this investigation, we utilized fused deposition modeling (FDM) technology fabricate high-precision porous...

Abnormal neutrophils are involved in many chronic endocrine diseases, including type 2 diabetes mellitus (T2DM), and periodontitis (PD), which is a inflammatory disease play vital role. The p38 mitogen-activated protein kinase (MAPK) signaling pathway participates the apoptosis of cells. Additionally, 1,25-dihydroxyvitamin-D3 (1,25VitD3) as regulator can induce responses to infection tumor cell apoptosis. However, effect 1,25VitD3 pathogenic relationship between T2DM PD remains unclear. aim...

The bone healing defects resulting from disease remain a significant clinical challenge. tissue engineering scaffolds combined with osteoinductive compounds represent an effective approach to overcome this In study, novel chitosan-based scaffold was prepared by incorporating modified natural diatomite (DE) as filler and adsorption element. Specifically, modified-diatomite (MDE) synthesized grafting polyethyleneimine (PEI) on the surface of via hydroxyl groups. physicochemical characteristics...

In this study, highly active Fe3O4@PDA@Au@GO surface-enhanced Raman spectroscopy (SERS) substrate was synthesized for application in the enrichment and detection of trace polycyclic aromatic hydrocarbons (PAHs) environment. The morphology structure were characterized by transmission electron microscopy (TEM), energy-dispersive (EDS), X-ray diffraction (XRD) UV-visible absorption spectrum (UV-vis spectra). effect each component nanocomposites on SERS explored, it found that gold nanoparticles...

Abstract Diabetes mellitus is one of the key diseases clinical concern that can lead to a variety serious complications and it characterized by increased blood glucose levels. Glucose‐sensitive hydrogel gaining attention as smart capable sensing molecules for diabetes related complications. In order better understand this hydrogel, paper reviews its basic design principles focuses on therapeutic efficacy in delivering insulin, drugs, bioactives diabetes‐related Its use biosensing device...

With the rapid development of chemical engineering and biotechnology, polypeptide, as a promising candidate in biomedical field, has been thoroughly investigated extensively used drug delivery vehicle for diseases treatment, especially cancer, owing to high biocompatibility, good biodegradability, versatile constructions, diverse functions. Engineered polypeptide-based system (so-called EPP-DDS) can deliver cargos target site via specific recognition effect, followed by overcoming barriers...

Diabetes has made it challenging to repair alveolar bone defects. A successful method for utilizes a glucose-sensitive osteogenic drug delivery. This study created new nanofiber scaffold with controlled dexamethasone (DEX) release. DEX-loaded polycaprolactone/chitosan nanofibers scaffolds were using electrospinning. The had high porosity (>90%) and proper loading efficiency (85.51 ± 1.21%). Then, glucose oxidase (GOD) was immobilized on the obtained by natural biological cross-linking agent,...

Abstract Background Several factors can influence the risk of dental caries, among which dietary have a significance impact on occurrence caries. The limitation current studies is that they only focus individual foods This study use cluster analysis to examine relationship between patterns and caries experience adolescents aged 12–15. Methods Based data from first oral epidemic survey in Shanxi Province, cross-sectional was conducted 11,351 12–15 Province through examination questionnaires....

A method for surface-enhanced Raman spectroscopy (SERS) sensing of polycyclic aromatic hydrocarbons (PAHs) is reported. Fe3O4@PDA@Ag@GO developed as the SERS substrate prepared by classical electrostatic attraction based on enrichment organic compounds graphene oxide (GO) and polydopamine (PDA) good separation function Fe3O4. The morphology structure were represented transmission electron microscopy (TEM), energy-dispersive (EDS), X-ray diffraction (XRD) UV-visible absorption spectrum...

ABSTRACT Restoring alveolar bone defects in patients with diabetes poses a significant challenge the treatment of oral disease. This study involved fabrication porous composite hydrogel scaffolds composed photo‐crosslinked chitosan/nanohydroxyapatite via extruded 3D printing. Additionally, glucose oxidase (GOx) and catalase (CAT) were immobilized onto scaffold through EDC/NHS covalent cross‐linking to develop novel 3D‐printed glucose‐sensitive utilizing an enzyme cascade reaction. The had...

Abstract Three‐dimensional (3D) printing of hydrogels to form complex structures has been widely used in tissue engineering. Projection‐based 3D (PBP) faster printing, lower cell damage, and higher resolution compared with other methods, providing a potential strategy for elaborate hydrogel structures. In this review, we introduced the composition process PBP. We then discuss study PBP, including chemical structure modification property optimization. More importantly, highlight applications...

Polyvinyl chloride microplastics (PVC MPs) have attracted a lot of attention regarding their potential environmental and health risks. However, effects on the microbial interaction in anammox process are still unclear. In this study, long-term different concentrations PVC MPs (i.e., 0, 1, 15, 50 mg/L) were investigated. The results showed that rise concentration led to gradual decrease particle size sludge granules an increase Proteins (PN)/polysaccharides (PS) ratio extracellular polymeric...

Abstract In the complicated process of bone regeneration, osteogenic differentiation and angiogenesis are crucial. this study, a novel dual small molecule composite electrospun scaffold was prepared using polycaprolactone embedded with angiogenic factor tauro‐ursodeoxycholic acid dexamethasone to promote early osteogenesis. Additionally, related properties, activity, activity analyses were conducted for scaffold. The results demonstrated that possessed proper mechanical properties...

To investigate the mineralized capacities of ectomesenchymal stem cells (EMSC) from facial process Sprague Dawley(SD) rat embryo different age in vitro and expression p75 neurotrophin receptor(p75NTR) this process.The cell surface antigens EMSC 12.5 d, 15.5 d 18.5 SD embryonic were tested by flow cytometry technology. E12.5 EMSC, E15.5 E18.5 incubated under mineralization induction analysed alkaline phosphatase(ALP) staining on day 7(d7) alizarin red 21(d21). Expression changes Runt-related...