A5037918865- Synthesis and bioactivity of alkaloids
- Fungal Plant Pathogen Control
- Plant-Microbe Interactions and Immunity
- Cancer therapeutics and mechanisms
- Plant pathogens and resistance mechanisms
- Toxin Mechanisms and Immunotoxins
- Phytochemical compounds biological activities
- Insect Pest Control Strategies
- Insect-Plant Interactions and Control
- Berberine and alkaloids research
- Boron and Carbon Nanomaterials Research
- Metal complexes synthesis and properties
- Thallium and Germanium Studies
- Synthesis and Biological Evaluation
- Insect and Pesticide Research
- Plant Pathogenic Bacteria Studies
- Synthesis and biological activity
Lanzhou University
2018-2024
Lanzhou City University
2019
State Council of the People's Republic of China
2019
Phytopathogenic fungal infections have become a major threat to agricultural production, food security, and human health globally, novel antifungal agents with simple chemical scaffolds high efficiency are needed. In this study, we designed synthesized 38 8-hydroxyquinoline metal complexes evaluated their activities. The results showed that most of the tested compounds possessed remarkable in vitro activity. Especially, compound 1e exhibited highest potency among all target compounds, EC50...
Inspired by quinine and its analogues, we designed, synthesized, evaluated two series of quinoline small molecular compounds (a 2a) six derivatives (3a–f) for their antifungal activities. The results showed that 3e 3f exhibited significant fungicidal Significantly, 3f-4 (EC50 = 0.41 μg/mL) 3f-28 0.55 displayed the superior in vitro activity potent vivo curative effect against Sclerotinia sclerotiorum. Preliminary mechanism studies could cause changes cell membrane permeability, accumulation...
Neocryptolepine is an alkaloid isolated from traditional African herbal medicine Cryptolepis sanguinolenta, and its broad spectrum of biological activities has been illuminated in past decades. In this study, neocryptolepine derivatives (1–49) were designed synthesized economical readily available starting materials. Their structures confirmed by proton nuclear magnetic resonance, carbon mass spectrometry. The compounds screened for their antifungal profile against six agriculturally...
Bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv (Xoo) is extremely harmful to rice production. The traditional control approach use bactericides that target key bacterial growth factors, but the selection pressure on pathogen makes resistant strains dominant strains, leading a decline in bactericidal efficacy. Type III secretion system (T3SS) conserved and critical virulence factor most Gram-negative bacteria, its expression or absence does not affect growth, rendering it an...
Phytopathogenic fungi have become a serious threat to the quality of agricultural products, food security and human health globally, necessitating need discover new antifungal agents with <italic>de novo</italic> chemical scaffolds high efficiency.
Rhizoctonia solani causes serious plant diseases. Neocryptolepine presented the significant antifungal activity against R. solani, however mode of action is unclear. In this paper, we investigated potential neocryptolepine integrated proteomics and transcriptomics. Results showed that after treatment with neocryptolepine, 1012 differentially expressed proteins 10 920 genes were found, most them enriched in mitochondrial respiratory chain. It affected oxidative phosphorylation led to...
In an attempt to find the neonicotinoid insecticides, twenty novel dihydropyridine derivatives were designed, "green" synthesized via one pot facile three-component reaction and evaluated for their bioactivities against Tetranychus cinnabarinus, Myzus persicae, Brevicoryne brassicae, Fusarium oxysporum f. sp. vasinfectum, Magnaporthe oryzae, Sclerotinia sclerotiorum Botrytis cinereal. All of tested compounds showed potent insecticidal activity, some much better in comparison with...