A5101745298- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Pancreatic and Hepatic Oncology Research
- X-ray Diffraction in Crystallography
- HER2/EGFR in Cancer Research
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Crystallization and Solubility Studies
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- Porphyrin and Phthalocyanine Chemistry
- Visual Attention and Saliency Detection
- Extracellular vesicles in disease
- PI3K/AKT/mTOR signaling in cancer
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Wnt/β-catenin signaling in development and cancer
- Drug Solubulity and Delivery Systems
- Advanced Nanomaterials in Catalysis
- AI in cancer detection
- Kruppel-like factors research
- Microtubule and mitosis dynamics
- Advanced Image Fusion Techniques
First Affiliated Hospital of Henan University of Science and Technology
2015-2024
Henan University of Science and Technology
2013-2022
Peking University
2019
Shenyang Pharmaceutical University
2016
Henan University
2014
174th hospital of the People's Liberation Army
2013
Xiamen University
2013
Bengbu Medical College
2007
The color variations present in histopathological images pose a significant challenge to computational pathology and, consequently, negatively affect the performance of certain pathological image analysis methods, especially those based on deep learning techniques. To date, several methods have been proposed mitigate this issue. However, these either produce with low texture retention, perform poorly when trained small datasets, or generalization capabilities. In paper, we propose Deep...
Long noncoding RNAs (lncRNAs) have emerged as important regulators of human cancers. LncRNA GAS5 (GAS5) is identified a tumor suppressor involved in several However, the roles and mechanisms responsible for its functions gastric cancer (GC) not been well documented. Herein, decreased increased miRNA-106a-5p levels were observed GC cell lines. level was significantly inversely correlated with tissues. Moreover, dual-luciferase reporter qRT-PCR assays showed that bound to negatively regulated...
Hypoxia regulation by drug delivery nanocargo is an unprecedented strategy for overcoming the inherent vices of traditional tumor treatments. Particularly, stimuli-responsive nanomaterials which are sensitive to external physical stimuli (light, ultrasound, magnetic field, etc.) greatly desired realize controllable release at lesions and avoid undesirable leakage during process. Herein, a photothermal mediated ROS self-enhanced CDT nanoplatform developed as anti-tumor nanoagents Vitamin C...
N6-methyladenosine (m6A) mRNA modification triggers malignant behaviors of tumor cells and thereby drives progression in gastric cancer (GC). However, data regarding the prognostic values m6A RNA methylation-related long non-coding RNAs (lncRNAs) GC are very limited literature. We aimed to investigate potential m6A-related lncRNAs predicting prognosis monitoring immunotherapy efficacy patients.Transcriptome clinical were obtained from biopsies Cancer Genome Atlas (TCGA). M6A-related...
Cyclin-dependent kinase inhibitor 3 (CDKN3) belongs to the dual-specificity protein phosphatase family, which is hypothesized regulate cell cycle progression in tumor cells. However, whether CDKN3 a potential therapeutic target for breast cancer remains be elucidated. The present vitro study aimed investigate roles of cancer. Breast lines were used detect expression, and expression was silenced its role apoptosis, arrest migration. underlying mechanisms screened by detecting proliferating...
Breast cancer is the most common malignant and second leading cause of cancer‑related death among women, its prevalence continues to increase. Axl overexpression has been identified in many types human cancer, it demonstrated participate signaling pathways related carcinogenesis development. In present study, expression was examined by performing immunohistochemical staining 60 breast tumors 40 benign lesions (25 mammary dysplasia 15 fibroadenoma). total, 34 (56.67%) tissues 13 (32.5%) were...
To investigate the apoptotic mechanism of triple-negative breast cancer (TNBC) cells induced by gefitinib and PI3K inhibitor SF1126. MDA-MB-231, MDA-MB-436, MCF-7 were incubated with 0.1 μmol/l gefitinib, 1 10 SF1126, gefitinib+1 Then, cell viability survival determined using an 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay Hoechst staining. The apoptosis-related factors phosphoinositide-3-kinase/protein kinase B, mammalian target rapamycin (PI3K/AKT-mTOR)...
Tumor-derived exosomes (exo) could modulate the biological behaviors of human umbilical vein endothelial cells (HUVECs). Here, role microRNA (miR)-10a-5p-modified gastric cancer (GC) cells-derived exo for HUVECs was studied. GC tissue specimens were collected, and miR-10a-5p zinc finger MYND-type containing 11 (ZMYND11) levels determined. interfered with ZMYND11 or miR-10a-5p-related oligonucleotides. Exo extracted from (HGC-27 exo), mimic-modified HGC-27 co-cultured HUVECs. viability,...
In the field of computer vision, application hand-crafted as well computer-learning-based methods in image quality assessment has yielded remarkable results. However, no-reference distortion, it is still challenging to accurately perceive and determine an image. To address difficulties Image Quality Assessment (IQA) authentic distorted images, we consider use Swin Transformer (ST) extract features. enable model focus on both spatial channel information features, design a plug-and-play Global...
ALDOA-related specific transcript (ARST) is a recently identified long non-coding RNA (lncRNA) that suppresses glioma progression, while its role in other cancers unclear. This study explored the of ARST colorectal cancer (CRC).The present included 60 CRC patients, patients with colon polyps (CP), colitis hemorrhoid and healthy controls. All participants were subjected to collection plasma, paired non-tumor tissues collected from patients. samples isolation RT-qPCR detect expression ARST....
Abstract Long non-coding RNAs (lncRNAs) have emerged as important regulators of human cancers. LncRNA GAS5 (GAS5) is identified tumor suppressor involved in several However, the roles and mechanisms responsible for its functions gastric cancer (GC) not been well undocumented. Herein, decreased increased miRNA-106a-5p levels were observed GC cell lines. expression level was significantly inversely correlated with tissues. Moreover, luciferase reporter qRT-PCR assays showed that bound to...
// Liangliang Lei 1 , Jianguang Wang Like Zhang Yanbin Chen Pengfei Yuan and Dechun Liu Department of Gastrointestinal Surgery, The First Affiliated Hospital, College Clinical Medicine Henan University Science Technology, Luoyang, Henan, China Correspondence to: Liu, email: liudechun33@163.com Keywords: pancreatic cancer, lncRNA, diagnosis, prognosis, meta-analysis Received: July 06, 2017 Accepted: August 17, Published: September 11, 2017 ABSTRACT Pancreatic...
Objective To investigate the roles of aberrant expression c-myc,c-myb,and c-erbB-2 in development breast cancer and its clinical significance.Methods Immunohistochimical technique (S-P method)was used to detect c-myb,c-myc protein 150 cases 30 benign proliferative lesions.heir relation pathological parameters were analyzed.Results The levels higher than those lesions difference was significant(all P ＜0.05).Expression c-myc had obvious relationship histological grade,lymph nodes metastasis...