A5100643292- Light effects on plants
- Seaweed-derived Bioactive Compounds
- Plant Molecular Biology Research
- Echinoderm biology and ecology
- Marine Sponges and Natural Products
- Plant pathogens and resistance mechanisms
- Molecular Sensors and Ion Detection
- Photosynthetic Processes and Mechanisms
- Supramolecular Chemistry and Complexes
- Structural Behavior of Reinforced Concrete
- Enzyme Production and Characterization
- Diabetes Management and Education
- Plant Physiology and Cultivation Studies
- Viral-associated cancers and disorders
- Concrete and Cement Materials Research
- Supramolecular Self-Assembly in Materials
- thermodynamics and calorimetric analyses
- Land Rights and Reforms
- Pharmaceutical Practices and Patient Outcomes
- Leaf Properties and Growth Measurement
- Structural Load-Bearing Analysis
- Genetic Mapping and Diversity in Plants and Animals
- Antimicrobial Resistance in Staphylococcus
- Medication Adherence and Compliance
- Colorectal and Anal Carcinomas
Fudan University
2024-2025
Zhongshan Hospital
2024-2025
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Shandong University
2024
Zhongkai University of Agriculture and Engineering
2024
Zhongshan Hospital of Xiamen University
2024
Shanghai Normal University
2017-2023
South China Normal University
2017-2022
Beijing Forestry University
2018
AbstractHere, we examined the in vitro and vivo anti-angiogenesis anti-tumor activities of PE, a new marine-derived compound. Inhibition angiogenesis was assessed using proliferation, migration, adhesion, tube-formation apoptosis assays PE-treated HMECs HUVECs. In vivo, CAM were used to assess inhibition effect PE on physiological angiogenesis, immunofluorescent microscopy examine tumor microvessel density mouse models. Finally, Western blotting analyses performed VEGF signaling HMECs. The...
Light is a key environmental cue that fundamentally regulates plant growth and development, which mediated by the multiple photoreceptors including blue light (BL) photoreceptor cryptochrome 1 (CRY1). The signaling mechanism of Arabidopsis thaliana CRY1 involves direct interactions with CONSTITUTIVE PHOTOMORPHOGENIC (COP1)/SUPPRESSOR OF PHYA-105 stabilization COP1 substrate ELONGATED HYPOCOTYL 5 (HY5). H2A.Z an evolutionarily conserved histone variant, plays critical role in transcriptional...
Concurrent inhibition of angiogenesis and immune checkpoints represents a potent therapeutic approach. We conducted phase 2, multicenter, basket study to assess the efficacy safety combination therapy famitinib (anti-angiogenic agent) plus camrelizumab (PD-1 antagonist) in patients with metastatic solid tumors across 11 cohorts (this was registered at Clinicaltrials.gov [NCT04346381]). This report focuses on cohort or advanced colorectal cancer. Eligible patients, who had previously received...
Arabidopsis cryptochrome 1 (CRY1) is an important blue light photoreceptor that promotes photomorphogenesis under light. The photoreceptors CRY2 and phototropin 1, the red/far-red phytochromes B A undergo degradation in response to red light, respectively. This study investigated whether how CRY1 might high-intensity (HBL). We demonstrated ubiquitinated degraded through 26S proteasome pathway HBL. found E3 ubiquitin ligase constitutive photomorphogenic (COP1) involved mediating HBL-induced...
Abstract A new lanostane‐type triterpene glycoside, impatienside ( 1 ), was isolated from the sea cucumber Holothuria impatiens , together with a structurally related, known compound, bivittoside D 2 ). Their structures were elucidated by in‐depth spectroscopic and mass‐spectrometric methods, including H‐, 13 C‐, 2D‐NMR, ESI‐MS, HR‐ESI‐MS experiments, as well chemical evidence. Compounds possess same hexasaccharide moieties, but differ slightly in their holostane‐type aglycone. The two...
Phytochromes A and B (phyA phyB) are the far-red red lights photoreceptors mediating many light responses in Arabidopsis thaliana. Brassinosteroid (BR) is a pivotal phytohormone regulating variety of plant developmental processes including photomorphogenesis. It known that phyB interacts with BES1 to inhibit its DNA-binding activity repress BR signaling. Here, we show modulate signaling through phyA regulation stability BIN2, glycogen synthase kinase 3 (GSK3)-like phosphorylates BES1/BZR1...
COVID-19 associated pulmonary aspergillosis (CAPA) had been reported, and raised concern about this secondary infection due to the high mortality. This study aimed investigate risk factors for CAPA. The enrolled 114 patients were further divided into CAPA group non-CAPA group. Demographic characteristics, underlying diseases, laboratory parameters therapeutic schedule between two groups compared identify independent by univariate analysis multivariable logistic regression analysis....
Two new sulfated triterpene glycosides, philinopside E (1) and F (2), have been isolated from the sea cucumber Pentacta quadrangularis. Their structures established by extensive spectral analysis (NMR MS) chemical evidence. Glycoside 1 showed significant cytotoxicity (Ed(50) 0.75-3.50 microg mL(-1)) against ten tumor cell lines.
<i>FLOWERING LOCUS T</i> (<i>FT</i>) is an important factor for integrating flowering signals through the photoperiod pathway, which significantly promotes flowering. Most chrysanthemum varieties are short-day plants, sensitive to photoperiod, limits their ornamental and annual production supply. In this study, we aim analyze nutrients flowering-related genes of chrysanthemums with different types clone verify function gene <i>CmFT</i>. We found that formation floral buds requires...
Aim: To investigate the clinical features, diagnosis and treatment of lymphoepithelioma-like carcinoma (LELC).
Powdery mildew is one of the severe diseases on common bean in Southwestern China, but identity pathogen inciting this disease unclear. The objective study was to identify causal agent powdery and screen resistant cultivars. identified through morphological identification, molecular phylogenetic analysis, pathogenicity tests. Resistance cultivars evaluated by artificial inoculation at seedling stage. isolate CBPM1 obtained after isolation purification. Morphological identification confirmed...
Three new triterpenoid aglycones named Philinopgenin A (1), B (2), and C (3) were isolated from the acid hydrolysate of crude glycoside mixture prepared whole sea cucumber Pentacta quadrangulasis Lesson. The corresponding structures determined as 16β-acetoxyholosta-8(9), 24(25)-diene-3β-ol 20, 25-epoxy-lanosta-9(11)-ene-3β-ol 18(16)–lactone (2) 16β-acetoxyholosta-9(11), (3), respectively, on basis spectral evidence.
Crop modeling, a widely used tool to predict plant growth and development in heterogeneous environments, has been increasingly integrated with genetic information improve its predictability. This integration can also shed light on the mechanistic path that connects genotype particular phenotype under specific environments. We implemented bivariate statistical procedure map identify quantitative trait loci (QTLs) form of by estimating cultivar-specific parameters incorporating these into...
Abstract In order to reduce the cost of Engineered Cementitious Composite (ECC), a feasibility study ECC using Cost-Effective Polyvinyl Alcohol (PVA) fiber (CEPVA-ECC) was developed based on micromechanical design theory. A set ECCs with different amounts fly ash replacement (up 83 % cement) prepared. The CEPVA-ECC much cheaper Chinese domestic PVA (1/6–1/4 price imported fiber) maintained tensile ductility characteristics (4–5 %) moderate compressive strength (30–40 MPa). crack width...
Multimorbidity and polypharmacy have emerged as significant global issues, heightening the risks of potentially inappropriate medications (PIMs). This necessitates medication optimization through deprescribing. Understanding patients' decision-making preferences regarding cessation is crucial for mitigating medication-related risks. study aims to capture attitude patients with multimorbidity towards deprescribing in rural China ascertain whether individual characteristics were linked these attitudes.
Owing to the unique macrocyclic-cavity structure of crown ether and capability complexing with guest molecules, our group successfully designed synthesized a novel Sailboat-Shaped self-complex by using intramolecular hydrogen bonds, which are able switch its configuration during different pH value.Furthermore, catenane based on sailboat-shaped was obtained intermolecular charge transfer interaction through template-directed method, identified 1 H NMR, 13 C HRMS H-1 NOESY.It is hoped that it...
Abstract Herein, we present the syntheses of two new crown‐ether‐based cryptands and their complexation behaviors with neutral organic molecules. The interactions between 4 / 5 G1 G2 were fast exchange systems forming pseudorotaxane‐like complexes a 1 : stoichiometric ratio. association constant ( K ) “long‐armed” cryptand was even up to 2.5×10 M −1 , which is 10 3 times higher than previously reported host‐neutral guest system best our knowledge. Such large comparable that secondary...