A5101911394- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Pharmacological Effects of Natural Compounds
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- RNA Research and Splicing
- RNA modifications and cancer
- Genomics, phytochemicals, and oxidative stress
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- RNA and protein synthesis mechanisms
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- PI3K/AKT/mTOR signaling in cancer
- T-cell and B-cell Immunology
- Lung Cancer Research Studies
- ATP Synthase and ATPases Research
- Tryptophan and brain disorders
- Ginseng Biological Effects and Applications
- Natural Compounds in Disease Treatment
- Histone Deacetylase Inhibitors Research
- Cancer, Stress, Anesthesia, and Immune Response
Sichuan Academy of Traditional Chinese Medicine
2025
China Jiliang University
2022-2024
Sir Run Run Shaw Hospital
2016-2023
Zhejiang University
2023
Ministry of Agriculture and Rural Affairs
2022
University of Macau
2016-2022
South China Agricultural University
2022
Xiang Yang No.1 People's Hospital
2021
Guangzhou Medical University
2020
First People's Hospital of Nanning
2020
Abstract Interleukin-12 (IL-12) can be used as an immunomodulator in cancer immunotherapy. And it has demonstrated enormous potential inhibiting tumor growth and improving the microenvironment (TME) by several preclinical models. However, some disappointing results have showed early clinical trials when IL-12 a single agent for systemic therapy. Combination therapy is effective way to significantly fulfill great of immunomodulator. Here, we discuss effects combined with traditional methods...
The anti-phagocytosis signal, CD47, prevents phagocytosis when it interacts with signal-regulatory protein alpha (SIRPα) on macrophages. Given the vital role of CD47 in immune response, further investigation regulation tumor microenvironment is needed. Herein, we identified that interferon-gamma (IFN-γ), one most important cytokines and inflammatory up-regulated expression cancer cells this effect could be inhibited by JAK1/2 inhibitor ruxolitinib, as well siRNA-mediated silencing JAK1,...
Fruit ripening is usually accompanied by anthocyanin accumulation. Ethylene key in ripening-induced production many fruits. However, the effects of fruit and ethylene on biosynthesis purple tomato fruits are unclear. This study shows that bagged cultivar 'Indigo Rose' failed to produce anthocyanins at red stage after bag removal. In contrast, immature accumulated a significant amount removing bags. The transcriptomic analyses between before removal revealed anthocyanin-related genes,...
The aim of the study was to validate expression protein tyrosine kinase 6 (PTK6) in nonsmall cell lung cancer (NSCLC), and evaluate its clinicopathological prognostic significance.We first conducted a meta-analysis on mRNA profiling data sets NSCLC Oncomine database. Then, one most significantly upregulated targets, PTK6, further validated by immunohistochemistry 104 primary tumors. Furthermore association between PTK6 expression, clinical parameters, overall survival analyzed.Using...
The mammalian target of rapamycin (mTOR) pathway is abnormally activated in lung cancer. However, the anti-lung cancer effect mTOR inhibitors as monotherapy modest. Here, we identified that ginsenoside Rh2, an active component Panax ginseng C. A. Mey., enhanced anti-cancer inhibitor everolimus both vitro and vivo. Moreover, Rh2 alleviated hepatic fat accumulation caused by xenograft nude mice models. combination (labeled Eve-Rh2) induced caspase-independent cell death cytoplasmic vacuolation...
IRF8 is a transcription factor with critical role in B lymphocyte development and functions. Its human diffuse large B-cell lymphoma (DLBCL), however, remained elusive. In this study, using shRNA-mediated knockdown of expression, we found that the loss significantly reduced proliferation DLBCL cells (P<0.05). Mechanistically, decreasing levels led to suppression phosphorylation p38 ERK, molecules for cell proliferation. Furthermore, xenograft mouse model, inhibited growth lymphomas vivo...
CD300A is a type I transmembrane receptor protein which has shown inhibitory effects on B-cell receptor-mediated signals. In an analysis of public dataset, we found that mRNA levels were inversely correlated with the overall survival time patients diffuse large lymphoma (DLBCL). To decipher role in DLBCL, knocked down expression DLBCL cells and decreasing significantly inhibited cell proliferation OCI-Ly01, Farage, SUDHL-4 cells, but not VAL, OCI-Ly10, or SUDHL-8 cells. Mechanistically,...
Abstract Background BLCA is a common cancer worldwide, and it both aggressive fatal. Immunotherapy (ICT) has achieved an excellent curative effect in BLCA; however, only some patients can benefit from ICT. MT1L pseudogene, previous study suggested that be used as indicator of prognosis colorectal cancer. However, the role not yet been determined. Methods Data were collected TCGA, logistic regression, Kaplan-Meier plotter, multivariate Cox analysis performed to demonstrate correlation between...
Abstract Lung cancer is the leading cause of death worldwide, which lung adenocarcinoma (LUAD) most common subtype. Metastasis major poor prognosis and mortality for patients, urgently needs great efforts to be further explored. Herein, glutathione peroxidase 8 (GPX8) was identified as a novel potential pro‐metastatic gene in LUAD metastatic mice models from GEO database. GPX8 highly expressed tumor tissues, predicting patients. Knockdown inhibited metastasis vitro vivo, while it did not...
As an emerging class of RNA molecules, circular RNAs play pivotal roles in various biological processes, thereby determining their three-dimensional (3D) structure is crucial for a deep understanding significances. Similar to linear RNAs, the development computational methods 3D prediction challenging, especially considering inherent flexibility and potentially long length RNAs. Here, we introduce extension our previous IsRNA2 model, named IsRNAcirc, enable predictions through coarse-grained...
Pemetrexed (PMT) is a multitargeted antifolate agent that used for treating patients with Non-Small Cell Lung Cancer (NSCLC). However, have presented clinical responses of drug resistance to PMT. This study aimed explore the underlying mechanisms PMT in NSCLC cells. PMT-resistant NCI-H460/PMT cells were established by concentrationescalation manner. MTT assay and colony formation performed detect cell proliferation. Immunofluorescence was expression Ki-67. Transwell measure migration...
Abstract The metallothionein 1 (MT1) family was previously shown to be involved in metal ion homeostasis, DNA damage, oxidative stress, and carcinogenesis. Our team’s previous study showed that MT1X is most closely associated with ccRCC. However, its role clear cell RCC (ccRCC) remains unclear. present aimed demonstrate MT1X’s prognostic value, potential biologic function, impact on the immune system, influence growth, cycle, apoptosis, migration setting of relationship between clinical...
Shenling Baizhu Powder (SBP), a famous Traditional Chinese Medicine (TCM) formulation, has been widely used in the adjuvant treatment of cancers, including breast cancer. This study aims to identify potential new targets for cancer based on network pharmacology SBP.By analyzing relationship between herbs and target proteins, multiple SBP were identified by analysis. Besides, comparing data tissue with normal tissue, upregulated genes two expression profiles found. Thereafter, level prognosis...