A5090573566- Malaria Research and Control
- Computational Drug Discovery Methods
- Genomics and Phylogenetic Studies
- vaccines and immunoinformatics approaches
- Mosquito-borne diseases and control
- Invertebrate Immune Response Mechanisms
- Vibrio bacteria research studies
- Bioinformatics and Genomic Networks
- Melanoma and MAPK Pathways
- Aquaculture disease management and microbiota
- Yersinia bacterium, plague, ectoparasites research
- Machine Learning in Bioinformatics
- RNA and protein synthesis mechanisms
- CAR-T cell therapy research
- Cutaneous Melanoma Detection and Management
- Cancer Genomics and Diagnostics
- Microbial Natural Products and Biosynthesis
- Gene expression and cancer classification
- Genomics and Chromatin Dynamics
- Cancer Immunotherapy and Biomarkers
- Synthesis and biological activity
- Plant Disease Resistance and Genetics
- RNA modifications and cancer
- Protein Structure and Dynamics
- Microbial Metabolic Engineering and Bioproduction
Fudan University
2016-2024
Zhongshan Hospital
2016-2024
College of Staten Island
2011-2023
City University of New York
2011-2023
Zhongshan Hospital of Xiamen University
2023
Shanghai Sixth People's Hospital
2016
The First Affiliated Hospital, Sun Yat-sen University
2016
Sun Yat-sen University
2016
Drexel University
2011
The Graduate Center, CUNY
2009
Abstract Background Ichthyophthirius multifiliis , commonly known as Ich, is a highly pathogenic ciliate responsible for 'white spot', disease causing significant economic losses to the global aquaculture industry. Options control are extremely limited, and Ich's obligate parasitic lifestyle makes experimental studies challenging. Unlike most well-studied protozoan parasites, Ich belongs phylum composed primarily of free-living members. Indeed, it closely related model organism Tetrahymena...
Abstract Background Streptomycetes are filamentous soil-dwelling bacteria. They best known as the producers of a great variety natural products such antibiotics, antifungals, antiparasitics, and anticancer agents decomposers organic substances for carbon recycling. also model organisms studies gene regulatory networks, morphological differentiation, stress response. The availability sets genomes from closely related Streptomyces strains makes it possible to assess mechanisms underlying...
Cancer is a disease of genome instability and genomic alterations; now, heterogeneity rapidly emerging as defining feature cancer, both within between tumors. Motivation for our pilot study tumor in esophageal squamous cell carcinoma (ESCC) that it not well studied, but the highest incidences cancers are found China ESCC most common type. We profiled mutations changes copy number were identified by whole-exome sequencing array-based comparative hybridization multiple regions an from two...
Abstract Background Melanoma is the deadliest form of skin tumor, and G protein-coupled receptors (GPCRs) play crucial roles in its carcinogenesis. Furthermore, tumor microenvironment (TME) affects overall survival (OS) response to immunotherapy. The combination GPCRs TME from a multi-omics perspective may help predict melanoma patients their Methods Bulk-seq, single-cell RNA sequencing (scRNA-seq), gene mutations, immunotherapy responses, clinicopathologic feature data were downloaded...
Summary EPCR is a type I transmembrane protein, highly expressed on the endothelium of large vessels, that binds protein C and augments its activation. In this study, 23bp insertion in gene was found 4/198 survivors myocardial infarction 3/194 patients with deep vein thrombosis. The predicts lacks part extracellular domain, domain cytoplasmic tail. Expression studies showed truncated not localized cell surface, cannot be secreted culture medium, does bind activated C. Since activation...
Abstract Melanoma is one of the most prevalent skin cancers, with high metastatic rates and poor prognosis. Understanding its molecular pathogenesis crucial for improving diagnosis treatment. Integrated analysis multi-omics data from 207 treatment-naïve melanomas (primary-cutaneous-melanomas (CM, n = 28), primary-acral-melanomas (AM, 81), primary-mucosal-melanomas (MM, metastatic-melanomas ( 27), nevi 43)) provides insights into melanoma biology. Multivariate reveals that PRKDC amplification...
Streptomyces is a group of soil bacteria medicinal, economic, ecological, and industrial importance. It renowned for its complex biology in gene regulation, antibiotic production, morphological differentiation, stress response. In this review, we provide an overview the recent advances inspired by -omics based high throughput technologies. post-genomic era, vast amounts data have been integrated to significant new insights into fundamental mechanisms system control regulation dynamics Streptomyces.
As a novel immune checkpoint, CD73 has been reported to play prominent roles in several malignancies. However, the significance of melanoma remains ambiguous. This study sought reveal impact on tumor microenvironment (TME) and patients' prognosis, investigate whether could be therapeutic target Chinese melanomas, which were dominated by acral mucosal subtypes.Two independent cohorts 194 patients with enrolled. PD-L1 expression as well CD8+ CD56+ cell infiltrations evaluated...
Abstract Background Malaria causes over one million deaths annually, posing an enormous health and economic burden in endemic regions. The completion of genome sequencing the causative agents, a group parasites genus Plasmodium , revealed potential drug vaccine candidates. However, genomics-driven target discovery has been significantly hampered by our limited knowledge cellular networks associated with parasite development pathogenesis. In this paper, we propose approach based on aligning...
Malaria continues to be one of the most devastating global health problems due high morbidity and mortality it causes in endemic regions. The search for new antimalarial targets is priority because increasing prevalence drug resistance malaria parasites. Malarial proteases constitute a class promising therapeutic as they play important roles parasite life cycle possible design screen specific protease inhibitors. In this mini-review, we provide phylogenomic overview malarial proteases. An...
The steadily increasing number of prokaryotic genomes has accelerated the study genome evolution; in particular, availability sets from closely related bacteria facilitated exploration mechanisms underlying plasticity. family Vibrionaceae is found Gammaproteobacteria and abundant aquatic environments. Taxa are diversified their life styles; some species free living, others symbiotic, human pathogens. This diversity makes this a useful set model organisms for studying bacterial evolution....
Species of the family Vibrionaceae are ubiquitous in marine environments. Several these species important pathogens humans and species. Evidence indicates that genetic exchange plays an role emergence new pathogenic strains within this family. Data from sequenced genomes could show how genes encoded by all strains, known as pangenome, distributed. Information about core, accessory panproteome can how, for example, encoding virulence-associated proteins distributed help us understand...
Melanoma is the most dangerous form of skin cancer because its high metastatic potential. Potential-N6-methyladenosine (m6A)-related long noncoding RNAs (pMRlncRNAs) play a vital role in malignancy. The identification prognostic-related pMRlncRNAs and development risk signatures could improve prognosis promote precise treatment melanoma.Gene expression relevant clinical data were obtained from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Prognostic-related selected...