A5046970891- Sarcoma Diagnosis and Treatment
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Bone Tumor Diagnosis and Treatments
- Lymphoma Diagnosis and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Nanowire Synthesis and Applications
- Urologic and reproductive health conditions
- Immune Cell Function and Interaction
- Vascular Tumors and Angiosarcomas
- Galectins and Cancer Biology
- Invertebrate Immune Response Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Ion Channels and Receptors
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
Zhongshan Hospital
2021-2024
Fudan University
2021-2024
Sun Yat-sen University
2021-2024
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Shanghai Medical College of Fudan University
2023
The study aimed to build and validate practical nomograms predict overall survival (OS) cancer-specific (CSS) for patients with synovial sarcoma (SyS).A total of 893 eligible confirmed have SyS between 2007 2015 were selected from the Surveillance, Epidemiology, End Results (SEER) database. Patients randomly divided into training cohort (n = 448) validation 445). Clinically independent prognostic important factors determined according Akaike information criterion in multivariate Cox...
As a novel immune checkpoint, CD73 has been reported to play prominent roles in several malignancies. However, the significance of melanoma remains ambiguous. This study sought reveal impact on tumor microenvironment (TME) and patients' prognosis, investigate whether could be therapeutic target Chinese melanomas, which were dominated by acral mucosal subtypes.Two independent cohorts 194 patients with enrolled. PD-L1 expression as well CD8+ CD56+ cell infiltrations evaluated...
Liposarcoma (LPS) is a rare and heterogeneous malignancy of adipocytic origin. Well-differentiated liposarcoma (WDLPS) dedifferentiated (DDLPS) are two the most common subtypes, showing similar genetic characterizations but distinct biological behaviors clinical prognosis. Compared to WDLPS, DDLPS more aggressive has potential metastasis, as malignant tumor's metabolic changes may have taken place during tumorigenesis LPSs. Therefore, investigate lipid alterations between high-resolution...
Long non-coding RNAs (lncRNAs) have been recently emerging as crucial molecules in multiple human cancers. However, their expression patterns, roles well the underlying mechanisms gallbladder cancer (GBC) remain largely unclear.The of lncRNAs GBC was downloaded from GEO database. Quantitative real-time polymerase chain reaction (qRT-PCR) and RNA situ hybridization (ISH) were used to detect tissues. The full-sequence LINC01410 determined by RACE assay. Subcellular distribution examined...
Leiomyosarcoma (LMS) is an aggressive mesenchymal malignant tumor with poor therapeutic options, but the molecular mechanisms underlying LMS remain largely unknown. Increasing evidence indicates that transient receptor potential vanilloid 4 (TRPV4) levels are closely related to advancement of various tumors through diverse mechanisms. However, roles and regulatory TRPV4 in progression unclear. Immunohistochemistry, Western blot, immunofluorescence were used investigate relationship between...
11569 Background: Anthracycline-based chemotherapy regimens are the cornerstone of first-line treatment recurrent/metastatic unresectable soft tissue sarcoma(STS)，while efficacy was not satisfactory (the median PFS: 4-8 months). Anti -angiogenesis TKI hypothetically can improve by remodeling immunosuppressive TME. We conducted this trial to explore safety and PD-1 antibody Penpulimab(P) plus anlotinib(A) epirubicin(E) in STS. The results phase I study were reported (2022 ESMO), updated...
11569 Background: Well-differentiated liposarcoma (WDLPS) and dedifferentiated (DDLPS) are common malignancies of adipocytic origin, which in different differentiation stages. Both them characterized by high local recurrence rate. The tumor microenvironment (TME) is associated with the prognosis immune-related cell infiltrations has been proved to be one mechanisms affecting efficacy immunotherapy. However, difference between TME characteristics WDLPS DDLPS as well association immune...
e23532 Background: Ewing sarcoma is a highly aggressive round cell mesenchymal tumor that commonly occurs in children and young adults. It molecularly characterized by chromosomal translocations, most t (11;22), resulting the abnormal EWSR1-FLI1 fusion. In addition to EWSR1-FLI1, patients may have other genomic variants can be used for risk stratification. present study, we retrospectively investigated association between co-variant genes prognosis with sarcoma. Methods: From 2019 2021, 10...