A5101852881- Diabetes and associated disorders
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- Prostate Cancer Treatment and Research
- T-cell and B-cell Immunology
- Cancer, Lipids, and Metabolism
- RNA regulation and disease
- Immunodeficiency and Autoimmune Disorders
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
- Nutrition, Genetics, and Disease
- Diabetes Management and Research
- Immune Cell Function and Interaction
- Curcumin's Biomedical Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Thyroid Disorders and Treatments
- Digestive system and related health
- Nigella sativa pharmacological applications
- Cancer-related gene regulation
- Connexins and lens biology
- Molecular Biology Techniques and Applications
- Prion Diseases and Protein Misfolding
- Helicobacter pylori-related gastroenterology studies
First Affiliated Hospital of Xi'an Jiaotong University
2024
China Energy Engineering Corporation (China)
2024
Anhui University of Finance and Economics
2023
Shanghai Maritime University
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Jinshan Hospital of Fudan University
2013-2020
Southeast University
2019
Beijing Hospital
2003-2019
Wenzhou City People's Hospital
2017
Zhengzhou University
2015-2016
Tumor necrosis factor-α (TNF-α) is an important inflammatory factor produced by activated macrophages and monocytes plays role in the pathogenesis of diabetic peripheral neuropathy (DPN). To evaluate effect TNF-α signaling suppression potential treatment DPN, a recombinant human receptor-antibody fusion protein (rhTNFR:Fc) was used. We focused on pathophysiology sciatic nerve examined expression myelin basic (MBP) under DPN status with or without inhibition.The rat model generated...
Recent evidence has shown the involvement of inflammation in development diabetic peripheral neuropathy (DPN). MicroRNA-146a (miR-146a) is closely involved inflammatory response. However, role miR-146a reaction DPN not been clarified. This study was designed to explore regulation responses DPN.Rats were randomly divided into three groups (n=6 per group): control group, type 2 diabetes mellitus (T2DM) group and group. T2DM rats intraperitoneally injected with streptozotocin. Sciatic nerve...
Currently, there are no effective treatments for diabetes-related cognitive dysfunction. Astaxanthin (AST), the most powerful antioxidant in nature, exhibits diverse biological functions. In this study, we tried to explore whether AST would ameliorate dysfunction chronic type 2 diabetes mellitus (T2DM) rats. The T2DM rat model was induced via intraperitoneal injection of streptozotocin. Forty Wistar rats were divided into a normal control group, an acute and group (treated with at dose 25...
Objective: It was demonstrated that inflammation and oxidative stress induced by hyperglycemia were closely associated with alteration of miR-146a. Here, we investigated the role miR-146a in mediating brain chronic T2DM rats. Methods: The (cT2DM) models intraperitoneal administration STZ (35 mg/kg) after being fed a high-fat, high-sugar diet for 6 weeks. H&E staining conducted to observe morphological impairment rat hippocampus. expressions inflammatory mediators (COX-2, TNF-α, IL-1β)...
Cognitive dysfunction is one of the serious complications induced by status epilepticus (SE), which has a significant negative impact on patients' quality life. Previous studies demonstrated that pathophysiological changes after SE such as oxidative stress, inflammatory reaction contribute to neuronal damage. A recent study indicated preventive astaxanthin (AST) alleviated epilepsy-induced stress and apoptosis in brain. In present study, rats were treated with vehicle or AST 1 h onset...
Nontoxic and nonimmunogenic nanoparticles play an increasingly important role in the application of pharmaceutical nanocarriers. The pathogenesis diabetic peripheral neuropathy (DPN) has been extensively studied. However, microRNAs DPN remains to be clarified. We verified vitro that miR-146a-5p mimics inhibited expression proinflammatory cytokines apoptosis. Then, we explored protective effect nanoparticle–miRNA-146a-5p polyplexes (nano-miR-146a-5p) on rats. demonstrated nano-miR-146a-5p...
Abstract Thymoquinone has been reported to exhibit antioxidant and anti-inflammatory effects. Inflammation plays an important role in pathogenesis of diabetic peripheral neuropathy. This study investigated the effects TQ on proliferation apoptosis Schwann cells exposed high glucose conditions electrophysiological morphological changes sciatic nerve a DPN rat model as well relevant inflammatory mechanism. Cell were measured using Counting Kit-8 flow cytometry. was established...
The development of the digital economy realizes optimization and upgrading industrial structure by cultivating new formats promoting integration traditional technologies. Based on data 30 provinces in China from 2013 to 2022, four-dimensional index system informatization, Internet, transaction, finance is constructed. Verifying fixed-effect model shows that has a significant role structure. It suggested priority should be given strengthening mechanism infrastructure innovation R&D...
The aim of this study was to investigate the association between signal transducer and activator transcription 3 (STAT3) polymorphisms autoimmune thyroid diseases clinical features. We genotyped six single-nucleotide (SNPs) rs1053005, rs2293152, rs744166, rs17593222, rs2291281, rs2291282 STAT3 gene in 667 patients with disease (417 Graves' (GD) 250 Hashimoto's thyroiditis (HT)) 301 healthy controls. allele A from rs1053005 significantly less frequent both GD HT (P = 0.0024, OR 0.6958, 95%CI...
The present study aimed to investigate the effects of glycerol on physical properties and release an insulin‑loaded polyvinyl alcohol (PVA) hydrogel film. composite film was produced using freeze‑thawing method, after which in vitro swelling ratio, transmittance insulin release, vivo pharmacodynamics, hydrogels containing various volumes were investigated. results demonstrated that addition reduced ratio increased softness PVA An analysis hypoglycemic rats had a sustained long‑acting effect...
Current evidence shows that apolipoprotein E (APOE), CI (APOC1) and low density lipoprotein receptor-related protein (LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in these genes associated with cognitive decline disease patients. We performed a 30-month longitudinal cohort study investigate the relationship between APOE, APOC1, LRP. In this study, 78 Chinese Han patients were recruited form Guangxi Zhuang Autonomous...
Autoimmune thyroid disease (AITD) is a multifactorial organ-specific autoimmune disorder, and both genetic susceptibility environmental factors are involved in its etiology. TNFAIP3 encodes the ubiquitin-modifying enzyme (A20), key regulator of inflammatory signaling pathways. The aim present study was to evaluate association between gene polymorphisms AITD Chinese Han population. Three single nucleotide (SNPs) locus (rs598493, rs610604 rs661561) were detected set 667 patients with 301...
The STAT4 gene encodes a transcriptional factor that transmits signals induced by several key cytokines which play important roles in the development of autoimmune diseases. aim this study was to explore association polymorphism with Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). A total 1048 thyroid diseases (AITDs) patients (693 GD 355 HT) 909 age- gender-matched controls were examined. polymorphisms (rs7574865/rs10181656/ rs7572482) genotyped multiplex polymerase chain reaction...
Healthy longevity has been an unremitting pursuit of human, but its genetic and the environment causes are still unclear.As population is a good healthy aging model for understanding how body begin process aging, plasma lipids metabolism balance very important to life maintain physiologic functional turnover.It explore effect variants associated long-life individuals on balance.Therefore, we developed comparative study based which contains 2816 2819 control.Through whole-exome sequencing...