A5101988593- Functional Brain Connectivity Studies
- Optical Imaging and Spectroscopy Techniques
- Dementia and Cognitive Impairment Research
- EEG and Brain-Computer Interfaces
- Heart Rate Variability and Autonomic Control
- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipose Tissue and Metabolism
- Stroke Rehabilitation and Recovery
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Health and Risk Factors
- Alzheimer's disease research and treatments
- Emotion and Mood Recognition
- Neurological Disease Mechanisms and Treatments
- Lipid metabolism and disorders
- Hormonal Regulation and Hypertension
- Sleep and related disorders
- Biochemical effects in animals
- Mitochondrial Function and Pathology
- Additive Manufacturing Materials and Processes
- Genetic Associations and Epidemiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Computing and Algorithms
National Research Center for Rehabilitation Technical Aids
2017-2025
Ministry of Civil Affairs
2017-2024
Institute of Optics and Electronics, Chinese Academy of Sciences
2022-2024
Chinese Academy of Sciences
2024
University of Chinese Academy of Sciences
2022-2024
Henan University of Technology
2024
Beihang University
2020-2021
Riverside Hospital of Guangxi Zhuang Autonomous Region
2008-2019
Donghua University
2019
Motor performance is improved by stimulation of the agonist muscle during movement. However, related brain mechanisms remain unknown. In this work, we perform a functional magnetic resonance imaging (fMRI) study in 21 healthy subjects under three different conditions: (1) movement right ankle alone; (2) and simultaneous muscle; or (3) control area. We constructed weighted networks for each condition using connectivity. Network features were analyzed graph theoretical approaches. found that:...
Abstract Stroke remains the leading cause of long-term disability worldwide. Rehabilitation training is essential for motor function recovery following stroke. Specifically, limb linkage rehabilitation can stimulate in upper and lower limbs simultaneously. This study aimed to investigate task-related changes cortical activation effective connectivity (EC) within a functional brain network after stroke by using near-infrared spectroscopy (fNIRS) imaging. Thirteen patients with either left...
Alzheimer's Disease (AD) accounts for the majority of dementia, and Mild Cognitive Impairment (MCI) is early stage AD. Early accurate diagnosis dementia plays a vital role in more targeted treatments effectively halting disease progression. However, clinical requires various examinations, which are expensive require high level expertise from doctor. In this paper, we proposed classification method based on multi-modal data including Electroencephalogram (EEG), eye tracking behavioral AD MCI....
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by significant cognitive and behavioral impairments. Near-infrared (NIR) light treatment has shown potential in improvement previous studies. However, clinical trials of NIR for AD remain limited. Objective This study investigated the safety effects whole-head 810 nm therapy patients, including long-term efficacy. Methods An open-label pilot on patients was conducted. Nine completed 4-month (810 nm,...
Amnestic mild cognitive impairment (aMCI) is the prodromal period of more serious neurodegenerative diseases (e.g., Alzheimer's disease), characterized by declines in memory and thinking abilities. Auxiliary assessment early diagnosis aMCI are crucial preventing continued deterioration abilities; nevertheless, this task poses a formidable challenge due to inconspicuous nature symptoms. Functional near-infrared spectroscopy (fNIRS) non-invasive, low-cost, user-friendly neuroimaging technique,...
Objectives: To characterize gait disorders in patients with amnestic mild cognitive impairment (aMCIs) and determine the association between performance of function cognition. Methodology: In this study, we enrolled 38 aMCI 30 cognitively normal individuals controls (NC). Neuropsychological assessments included tests memory, executive function, language, attention. Using an inertial-sensor-based wearable instrument, collected data dynamically for at least 1 h/day 2 weeks. The parameters...
Impaired motor function is a common consequence of upper neuron lesions (UMNLs). Fine skills involved in small movements occurring the fingers, hand, and wrist are usually regained by patient self-training at home. Most studies focus on rehabilitation fingers but ignore recovery function. In this paper, three virtual guiding tasks were designed to assess functions, including basic flexibility, motion stability, range active motion. A haptic device was used provide feedback users who...
Current evidence shows that apolipoprotein E (APOE), CI (APOC1) and low density lipoprotein receptor-related protein (LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in these genes associated with cognitive decline disease patients. We performed a 30-month longitudinal cohort study investigate the relationship between APOE, APOC1, LRP. In this study, 78 Chinese Han patients were recruited form Guangxi Zhuang Autonomous...
Early detection of mild cognitive impairment is crucial in the prevention Alzheimer's disease (AD). This study aims to explore changes gait and brain co-functional connectivity between cognitively healthy impaired groups under dual-task walking through functional near-infrared spectroscopy (fNIRS) analysis devices. used fNIRS device devices collect data 54 older adults. According Mini-mental State Examination (MMSE) Montreal Cognitive Assessment (MoCA) scales, adults were (control group)...
Healthy longevity has been an unremitting pursuit of human, but its genetic and the environment causes are still unclear.As population is a good healthy aging model for understanding how body begin process aging, plasma lipids metabolism balance very important to life maintain physiologic functional turnover.It explore effect variants associated long-life individuals on balance.Therefore, we developed comparative study based which contains 2816 2819 control.Through whole-exome sequencing...
Stroke survivors suffering from deficits in motor control typically show persistent symptoms and limited functional abilities, which affect their independence daily life. Active rehabilitation training is commonly applied for stroke patients to recover dysfunction. The global connectivity reflects the synchronization of cardiac respiratory activities cerebral regions. However, understanding patterns frequency-specific (GC) (FC) when performing active still far comprehensive. This study was...