A5038965879- Sleep and related disorders
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Associations and Epidemiology
- Hormonal Regulation and Hypertension
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Thyroid Disorders and Treatments
- Diet and metabolism studies
- Genetics, Aging, and Longevity in Model Organisms
- Atherosclerosis and Cardiovascular Diseases
- Epigenetics and DNA Methylation
- Health, Environment, Cognitive Aging
- Cancer-related gene regulation
- Adipose Tissue and Metabolism
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Mitochondrial Function and Pathology
- Gut microbiota and health
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Health and Risk Factors
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
First Affiliated Hospital of Henan University of Science and Technology
2025
Beijing Hospital
2014-2024
State Council of the People's Republic of China
2024
Peking University
2010-2023
Beijing Geriatric Hospital
2016-2023
People's Hospital of Cangzhou
2020
Second Affiliated Hospital of Nanchang University
2018-2019
Nanchang University
2018-2019
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2018
FAT4 functions as a tumor suppressor, and previous findings have demonstrated that can inhibit the epithelial-to-mesenchymal transition (EMT) proliferation of gastric cancer cells. However, few studies investigated role in development colorectal (CRC). The current study aimed to detect invasion, migration, autophagy CRC elucidate probable molecular mechanisms through which interacts with these processes. Transwell invasion assays, MTT transmission electron microscopy, immunohistochemistry...
Dysfunction of β-cell is one major characteristics in the pathogenesis type 2 diabetes. The combination obesity and diabetes, characterized as 'diabesity', associated with elevated plasma free fatty acids (FFAs). Oxidative stress has been implicated FFA-induced dysfunction. However, molecular mechanisms linking between reactive oxygen species (ROS) dysfunction apoptosis are less clear. In present study, we test hypothesis that NOX2-derived ROS may play a critical role β-cells induced by FFA....
Abstract Background Gut bacteria Akkermansia has been shown an anti-obesity protective effect in previous studies and may be used as promising probiotics. However, the above confounded by common factors, such sex, age diets, which should verified a generalized population. Methods We datasets from American Project to strictly reassess association further examined of aging on it. A total 10,534 participants aged 20 99 years United States Kingdom were included. The relative abundance was...
Excessive copper (Cu) has risky effect on insulin resistance (IR), oxidative stress and inflammation. Instead, some studies reported serum Cu to be protective for non-alcoholic fatty liver disease (NAFLD). The aim of this study was reevaluate the evidence a potential correlation NAFLD in large-scale non-institutionalized American subjects.
Akkermansia muciniphila is among the most abundant bacterial species in human intestine; however, its relationship to metabolic syndrome (MetS)-which linked gut dysbiosis-is not known. In this study, we investigated association between abundance and risk of MetS components, as well dose-response effects influence microbial interactions on association. This cross-sectional study included 6896 Chinese participants aged 18 97 years from Guangdong Gut Microbiome Project. was defined according...
Abstract Background Inner Mongolia cashmere goat (IMCG), renowned for its superior quality, is a Chinese indigenous breed that has been developed through natural and artificial selection over long period. However, recently, the genetic resources of IMCGs have significantly threatened by introduction cosmopolitan breeds absence adequate protection systems. Results In order to assess conservation effectiveness efficiently preserve utilize purebred germplasm resources, this study analyzed...
Abstract Objective: This study aimed to develop a machine learning-based prediction model for hypoglycemia in hospitalized patients with type 2 diabetes mellitus (T2DM) by utilizing electronic medical records. The goal was establish reliable foundation creating web-based calculator or applet clinical use. Methods: Predictive variables were identified through comprehensive, evidence-based literature review. Potential risk factors extracted from records using SQL queries generated PLSQL...
Abstract Chronic granulomatous disease (CGD), caused by a lack of reactive oxygen species (ROS) generation the phagocyte NADPH oxidase NOX2, leads to massively increased inflammatory responses. In order identify type which requires NOX2 activity limit inflammation, we investigated mice with loss function mutation in Ncf1 gene coding for p subunit and transgenic rescue under control CD68 promoter. To induce CGD hyperinflammation, different mouse genotypes were injected intradermally β‐glucan....
// Huiping Yuan 1 , Xinghui Li 1, 2 Gang Wan 3 Liang Sun Xiaoquan Zhu Fugang Che and Ze Yang The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center Gerontology, Beijing, P.R. China College Public Health, Shaanxi University Chinese Medicine, Xianyang, Statistical Room, Ditan Hospital Capital University, Correspondence to: Yuan, email: yuanhuiping@126.com Yang, yang_ze@sina.com Keywords: type diabetes; prevalence; epidemic features; risk factors; temporal variation trend...
Defects in insulin secretion by pancreatic cells and/or decreased sensitivity of target tissues to action are the key features type 2 diabetes. It has been shown that excessive generation reactive oxygen species (ROS) is linked glucose-induced β-cell dysfunction. However, cellular mechanisms involved ROS β-cells and link between dysfunction poorly understood. Here, we demonstrate a role NADPH oxidase (NOX2)-derived deterioration function induced high concentration glucose. Sprague-Dawley...
Background The number of patients suffering from depression is continuously increasing in China. Demographic characteristics, physical health levels, and individual lifestyles/healthy behaviors are associated with the severity depression. However, major risk factor for remains unclear. Materials methods In this investigation, 16,512 were screened using CHARLS (China Health Retirement Longitudinal Study) database after being determined to be eligible based on inclusion criteria. Depressive...
Objective To investigate the relationship between sleep duration and activities of daily living (ADL) disability, to explore optimal among oldest-old Chinese individuals. Methods In this cross-sectional study, 1,798 participants (73.2% female) were recruited from Dongxing Shanglin in Guangxi Zhuang Autonomous Region, China 2019. The restricted cubic spline function was used assess dose-response ADL odds ratios (ORs) associations estimated by logistic regression models. Results overall...
Healthy longevity has been an unremitting pursuit of human, but its genetic and the environment causes are still unclear.As population is a good healthy aging model for understanding how body begin process aging, plasma lipids metabolism balance very important to life maintain physiologic functional turnover.It explore effect variants associated long-life individuals on balance.Therefore, we developed comparative study based which contains 2816 2819 control.Through whole-exome sequencing...
Branched-chain amino acids (BCAAs) and telomere length are biologically associated with healthy aging. However, the association between them their interaction on frailty remain unclear in humans. Here, a cross-sectional study based residents from Guangxi longevity county was conducted to investigate of serum BCAAs, peripheral leukocyte (LTL) frailty. A total 1,034 subjects aged 20 110 years were recruited study. The real-time qPCR method targeted metabolomics approach isotope dilution liquid...
: Rates of aging vary markedly among individuals, and biological age serves as a more reliable predictor current health status than does chronological age. As such, the ability to predict can support appropriate timely active interventions aimed at improving coping with process. However, process is highly complex multifactorial. Therefore, it scientific construct prediction model for from multiple dimensions systematically. Physiological biochemical parameters were evaluated gauge individual...