A5101448554- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Metabolism and Genetic Disorders
- Epigenetics and DNA Methylation
- Salmonella and Campylobacter epidemiology
- Ubiquitin and proteasome pathways
- CAR-T cell therapy research
- Hereditary Neurological Disorders
- Immunotherapy and Immune Responses
- Receptor Mechanisms and Signaling
- Cancer Immunotherapy and Biomarkers
- Caveolin-1 and cellular processes
- Bacteriophages and microbial interactions
- Identification and Quantification in Food
- interferon and immune responses
- Chromosomal and Genetic Variations
- Innovative Teaching Methods
- RNA regulation and disease
- Vibrio bacteria research studies
- RNA and protein synthesis mechanisms
- Genetic Neurodegenerative Diseases
- Genomics and Rare Diseases
University of Miami
2018-2025
Dr. John T. Macdonald Foundation
2020-2025
Guangxi Medical University
2024
Guizhou Center for Disease Control and Prevention
2019-2024
Zhongnan Hospital of Wuhan University
2018-2022
Wuhan University
2018-2022
Chiayi Chang Gung Memorial Hospital
2022
Second Affiliated Hospital of Shantou University Medical College
2022
Shantou University
2022
South China Agricultural University
2022
Abstract Cerebral palsy is the most prevalent physical disability in children; however, its inherent molecular mechanisms remain unclear. In present study, we performed in-depth clinical and analysis on 120 idiopathic cerebral families, identified underlying detrimental genetic variants 45% of these patients. addition to germline variants, found disease-related postzygotic mutations ∼6.7% We that patients with more severe motor impairments or a comorbidity intellectual had significantly...
Introduction Salmonella is a major foodborne pathogen worldwide that causes severe morbidity and mortality. It mainly caused by consuming contaminated food, with retail food considered the primary source. Methods In Guizhou, China, 102 strains isolated from 2016 to 2021 underwent phenotypic antimicrobial resistance testing whole-genome sequencing (WGS) understand diversity, including serotypes, types (STs), genes, virulence plasmid types, multi-locus sequence (MLST), core genome MLST...
Idiopathic pulmonary fibrosis (IPF) is a fibrotic interstitial lung disease with lesions confined to the lungs. To identify meaningful microRNA (miRNA) and gene modules related IPF progression, GSE32537 (RNA-sequencing data) GSE32538 (miRNA-sequencing were downloaded processed, then weighted co-expression network analysis (WGCNA) was applied construct networks miRNA networks. GSE10667, GSE70866, GSE27430 used make reasonable validation for results evaluate clinical significance of genes...
Biallelic loss-of-function mutations in the sorbitol dehydrogenase (SORD) gene cause most common recessive type of Charcot-Marie-Tooth disease (CMT), CMT-SORD. However, full genotype-phenotype spectrum and progression remain to be defined. Notably, a multicenter phase 2/3 study test efficacy govorestat (NCT05397665), new aldose reductase inhibitor, is currently ongoing. Diagnosing CMT-SORD will become imperative when disease-modifying therapies available. In this cross-sectional multicentre...
Introduction Bacillus cereus is a ubiquitous opportunistic human pathogen that causes food intoxications worldwide. However, the genomic characteristics and pathogenic mechanisms of B. are still unclear. Methods Here, we isolated purified nine strains ( LY01-LY09 ) caused vomiting, diarrhea other symptoms from four foodborne outbreaks happened in Guizhou Province southwest China June to September 2021. After colony observation, Gram staining, microscopic examination biochemical test, they...
Biallelic SORD mutations cause one of the most frequent forms recessive hereditary neuropathy, estimated to affect ∼10 000 patients in North America and Europe alone. Pathogenic loss-of-function changes encoded enzyme sorbitol dehydrogenase result abnormally high levels cells serum. How accumulation leads peripheral neuropathy remains be elucidated. A reproducible animal model for is essential illuminate pathogenesis deficiency preclinical studies potential therapies. Therefore, we have...
Arginyltransferase 1 (ATE1) is an evolutionary-conserved eukaryotic protein that localizes to the cytosol and nucleus. It only known enzyme in metazoans fungi catalyzes posttranslational arginylation. Lack of arginylation has been linked array human disorders, including cancer, by altering response stress regulation metabolism apoptosis. Although mitochondria play relevant roles these processes health disease, a causal relationship between ATE1 activity mitochondrial biology yet be...
SIK1-LNC represses the proliferative, migrative, and invasive abilities of lung cancer cells Liu Yang,1,* Nianlin Xie,2,* Jingyu Huang,3,* Hu Huang,4,* Shaogan Xu,5 Zhigang Wang,4 Jun Cai6 1Department Cancer Biotherapy Center, Hubei Hospital, Wuhan 430079, Hubei, People's Republic China; 2Department Thoracic Surgery, Tangdu The Fourth Military Medical University, Xi'an 710038, Shaanxi, 3Department Cardiovascular Zhongnan Hospital 430071, 4Department Oncology, 161th PLA, Wuhan, 430010,...
Tumor metastasis is the main cause of death in cancer patients. Early prediction tumor can allow for timely intervention. At present, research on mainly focuses manual diagnosis by imaging or computational methods. With deterioration tumor, gene expression levels blood change greatly. It feasible to measure transcripts key genes predict whether will metastasize. Therefore, this paper, we obtained data from 226 patients TCGA. These included 239,322 transcripts. Background screening and LASSO...
Esophageal squamous cell carcinoma (ESCC) is a common malignancy with poor prognosis and survival rate. To identify meaningful lncRNA, microRNA, mRNA modules related to the ESCC prognosis, TCGA-ESCC was downloaded processed, then weighted gene co-expression network analysis applied construct lnRNA networks, miRNA networks networks. Twenty-one hub lncRNAs, seven miRNAs, eight mRNAs were clarified. Meanwhile, lncRNA–miRNA–mRNA constructed, emerging role of being involved in head neck (HNSCC)...
Abstract MicroRNA‐125a (miR‐125a) is related to the occurrence, development, and prognosis of various cancers according relevant reports. However, its function role mechanism in non–small cell lung cancer (NSCLC) yet be explored. Herein, we investigated preliminary miR‐125a NSCLC. First, was noticeably downregulated NSCLC tissues contrast adjacent normal through real‐time quantitative polymerase chain reaction (RT‐qPCR) assay. The inverted result observed on STAT3 HAS1 expressions. Moreover,...
Long noncoding RNAs participate in carcinogenesis and tumor progression non-small-cell lung carcinoma (NSCLC), but the mechanisms underlying NSCLC tumorigenesis remain to be fully elucidated. Here, we reported functional role potential mechanism of long RNA syntaxin-binding protein 5-antisense 1 (STXBP5-AS1) NSCLC. First, our data revealed that expression levels STXBP5-AS1 31 tissues were lower than adjacent using quantitative polymerase chain reaction (qPCR) its was significantly associated...
Ovarian hyperstimulation syndrome (OHSS) is one of the most dangerous iatrogenic complications in controlled ovarian (COH). The exact molecular mechanism that induces OHSS remains unclear. In recent years, accumulating evidence found exosomal miRNAs participate many diseases reproductive system. However, specific role miRNAs, particularly follicular fluid-derived controversial. To identify differentially expressed fluid from and non-OHSS patients, analysis based on miRNA-sequence was...
Bulked segregant analysis (BSA) of a BC1 population derived from congguang 41A/MiYang 23//congguang 41B was used to map the nuclear fertility restorer gene Rf5 for HongLian (HL) cytoplasmic male sterility. The parents and two bulks representing extremely fertile sterile plants, respectively, were screened polymorphism with 20 microsatellite primer pairs on chromosome 10, chosen basis previous research. MRG4456 is linked at distance 1.57 cM, another newly developed primer, HL01, locked 0.63...
Owing to its high recurrence rate, gastric cancer (GC) is the leading cause of tumor-related deaths worldwide. Besides surgical treatment, chemotherapy most commonly used treatment against GC. However, adverse events associated with use limit effectiveness in GC treatment. In this study, we investigated effects using combinations low-dose 5-fluorouracil (5-FU; 0.001 and 0.01 mM) different concentrations escitalopram oxalate (0.01, 0.02, 0.06, 0.2 evaluate whether assessed combination would...
To conduct a study that examined the molecular epidemiology and pathogenesis of Salmonella Senftenberg isolates associated with an outbreak foodborne disease in Guizhou Province to provide reference basis for traceability salmonellosis outbreaks clinical diagnosis treatment province. Fourteen strains suspected isolated from patient stool food samples were used pathogenic identification serotyping by biochemical mass spectrometry methods. types antibiotics tested drug sensitivity microbroth...
Various microRNAs (miRNAs) are of importance in the development colon cancer, but most mechanisms miRNAs still unclear. In order to clarify hub and their roles cancer development, GSE98406 was used screen by bioinformatics analysis. 46 DE-miRNAs (14 were upregulated 32 downregulated) 1738 target genes ascertained. miRNAs-gene-networks miRNAs-GO-networks built get more knowledge about function candidate miRNAs. After validation, three (miR-17-5p, miR-182-5p miR-200a-3p) recognized be...
Objective To analyze the serotype distribution and antibiotic resistance characteristics of food-borne Salmonella strains isolated from food patients with gastroenteritis in Guizhou Province 2016 to 2018. Methods Serotypes were characterised using slid agglutination method antisera. Minimal inhibitory concentrations (MIC) antibiotics determined by broth microdilution method. Microsoft Excel 2007 SPSS18.0 used for statistical analysis. Results A total 170 detected 2018....
Abstract Cerebral palsy (CP), the most prevalent physical disability in children, has long been ignored with regard to its inherent molecular mechanism. In this work, we performed in-depth clinical and analysis on 120 idiopathic CP families, identified half of patients underlying risk factors. By a compilation 117 CP-related genes, recognized characteristic features terms inheritance function, proposed dichotomous classification system according expression patterns. two both intellectual...
Objective This study aims to develop risk prediction models for neck and shoulder musculoskeletal disorders among healthcare professionals. Methods A stratified sampling method was employed select employees from medical institutions in Nanning City, yielding 617 samples. The Boruta algorithm used feature selection, various models, including Tree-Based Models, Single Hidden-Layer Neural Network Models (MLP), Elastic Net (ENet), Support Vector Machines (SVM), were applied predict the selected...