A5070663387- Regional Economic and Spatial Analysis
- Natural product bioactivities and synthesis
- Signaling Pathways in Disease
- Crystallization and Solubility Studies
- Histone Deacetylase Inhibitors Research
- X-ray Diffraction in Crystallography
- Esophageal Cancer Research and Treatment
- 14-3-3 protein interactions
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Global Cancer Incidence and Screening
- Protein Degradation and Inhibitors
- MicroRNA in disease regulation
- Sesquiterpenes and Asteraceae Studies
- Supramolecular Self-Assembly in Materials
- Molecular Sensors and Ion Detection
- Angiogenesis and VEGF in Cancer
- Adipose Tissue and Metabolism
- Bioactive Natural Diterpenoids Research
- Luminescence and Fluorescent Materials
- Reproductive Health and Contraception
- Extracellular vesicles in disease
- Microbial Natural Products and Biosynthesis
- Mitochondrial Function and Pathology
- Plant Toxicity and Pharmacological Properties
East China Normal University
2014-2025
Wuhan University
2024
Obstetrics and Gynecology Hospital of Fudan University
2015-2024
State Ethnic Affairs Commission
2024
Southern Medical University
2020-2021
Hospital of Stomatology, Sun Yat-sen University
2021
Henan University of Economic and Law
2021
Sun Yat-sen University
2021
Xian Central Hospital
2019
Xinjiang Agricultural University
2019
Abstract Hepatocellular carcinoma (HCC) is a highly lethal malignant tumor, and the current non‐invasive diagnosis method based on serum markers, such as α‐fetoprotein (AFP), des‐γ‐carboxy‐prothrombin (DCP), has limited efficacy in detecting it. Therefore, there critical need to develop novel biomarkers for HCC. Recent studies have highlighted potential of exosomes biomarkers. To enhance exosome enrichment, silicon dioxide (SiO 2 ) microsphere‐coated three‐dimensional (3D) hierarchical...
Energy deprivation and metabolic rewiring of cardiomyocytes are widely recognized hallmarks heart failure. Here, we report that HEY2 (a Hairy/Enhancer-of-split-related transcriptional repressor) is upregulated in hearts patients with dilated cardiomyopathy. Induced Hey2 expression zebrafish or mammalian impairs mitochondrial respiration, accompanied by elevated ROS, resulting cardiomyocyte apoptosis Conversely, depletion adult mouse enhances the oxidation genes cardiac function. Multifaceted...
Breast cancer is one of the most lethal cancers in women when it reaches metastatic stage. Here, we screen a library small molecules for inhibitors breast cell invasion, and use structure/activity relationship studies to develop series with improved activity. We find WJ460 as lead compounds exerting anti-metastatic activity nanomolar range cells. Proteomic biochemical identify myoferlin (MYOF) direct target WJ460. In parallel, loss MYOF or pharmacological inhibition by reduces extravasation...
Abstract Rapid metabolism differentiates cancer cells from normal and relies on anaplerotic pathways. However, the mechanisms of anaplerosis‐associated enzymes are rarely understood. The lack potent selective antimetabolism drugs restrains further clinical investigations. A small molecule ZY‐444 (( N 4 ‐((5‐(4‐(benzyloxy)phenyl)‐2‐thiophenyl)methyl)‐ 2 ‐isobutyl‐2,4‐pyrimidinediamine) is discovered to inhibit cell proliferation specifically, having efficacies against tumor growth,...
Glycyrrhetinic acid (GA) is one of the most important triterpenoic acids shows many pharmacological effects, especially antitumor activity. GA triggers apoptosis in various tumor cell lines. However, activity weak, thus synthesis new synthetic analogs with enhanced potency needed. By introducing five-member fused heterocyclic rings at C-2 and C-3 positions, 18 novel derivatives were obtained. These compounds evaluated for their inhibitory against growth eight different lines using a SRB...
Pancreatic cancer is one of the most common cancers with an extremely low survival rate. Metastasis, as key reasons cancer-related death, found in more than 50% pancreatic patients at diagnosis. Novel therapeutic targets and drugs blocking metastasis are urgently needed. Herein, we report a series 1,5-diaryl-1,2,4-triazole derivatives potent antimetastatic agents. Lead compound 6y displayed effective activities vitro vivo. Concomitant studies indicated that probably binds myoferlin (MYOF),...
Histone deacetylase inhibitors (HDACi) are small molecules targeting epigenetic enzymes approved for hematologic neoplasms, which have also demonstrated clinical activities in solid tumors. In our present study, we screened internal compound library and discovered a novel HDACi, WW437, with potent anti-breast cancer ability vitro vivo. WW437 significantly inhibited phosphorylated EphA2 expression. Further study blocked HDACs-EphA2 signaling axis breast cancer. parallel, found that expression...
Abstract As a pivotal vesicular trafficking protein, Myoferlin (MYOF) has become an attractive target for cancer therapy. However, the roles of MYOF in colorectal invasion remain enigmatic, and MYOF‐targeted therapy this malignancy not been explored. In present study, we provided first functional evidence that promoted cell cancer. Furthermore, identified novel small molecule inhibitor (named YQ456) showed high binding affinity to (K D = 37 nM) excellent anti‐invasion capability (IC 50 110...
Abstract Background The increasing aging population has been posing a significant challenge to disease burden in developing countries. In particular, the contribution of and long term changes malignant neoplasm female genital organs (MNFGO) have not quantitatively demonstrated. Methods Data were collected from Shanghai Vital Statistics System Pudong New Area (PNA). Crude mortality rate (CMR), age-standardized by Segi’s world standard (ASMRW), years life lost (YLL) MNFGO as underlying cause...
Human Tid-1 (hTid-1) is a DnaJ chaperone protein with homology to the Drosophila tumor suppressor Tid56. We report first case of tumor-associated mutation at human TID1 locus, which was identified in SF767 glioma cell line giving rise aberrantly high levels hTid-1(L) mutant variant. In this study, we set out determine whether change hTid-1 status influences response cells adenoviral (Ad)-mediated delivery two major isoforms TID1, and hTid-1(S). Ad-hTid-1(S) induced apoptosis cells, while...
A novel acylhydrazide‐based gelator (BE) was successfully built without the use of traditional fluorescent groups. Surprisingly, in 1,2‐propanediol, BE can further self‐assemble into a stable supramolecular gel (OBE) and display significant blue‐white aggregation‐induced enhanced emission (AIEE). Interestingly, based on excellent coordination capacity acyl hydrazone bonds, OBE demonstrated sensitive response to Pd 2+ Fe 3+ , with corresponding lowest limits detection 21.8 37.3 ppb,...
Compounds targeting epigenetic events of tumours are likely to be an important addition anticancer therapy. Histone deacetylase inhibitors (HDACI) have emerged as a promising novel class for therapeutic interventions associated with cancer, and many them currently in clinical investigation. Here, we assessed hydroxamate-based HDACI, LW479, breast cancer progression explored its underlying mechanism(s).LW479 was identified using the HDACI screening kit. Western blot flow cytometry were used...
Metastasis is the primary cause of high mortality rates in head and neck squamous cell carcinoma (HNSCC). MicroRNA (miR)‑411‑5p has been discovered to serve an important role cancer metastases. However, best our knowledge, association between miR‑411‑5p expression levels HNSCC metastasis not thoroughly investigated. The present study aimed research function metastasis. results revealed that were upregulated patients with lymph node positively associated metastatic potential HNSCC. Moreover,...
Angiogenesis is the process of generating new blood vessels based on existing ones, which involved in many diseases including cancers, cardiovascular and diabetes mellitus. Recently, great efforts have been made to explore mechanisms angiogenesis various angiogenic factors discovered as therapeutic targets anti- or pro-angiogenic drug development. However, resulted information sparsely distributed no systematical summarization has made. In order integrate these related results facilitate...
Employing decoupling index and industrial structure characteristic bias methods, this study analyzed the spatial-temporal characteristics of transformations their resulting carbon emissions in Xuzhou Metropolitan Area from 2000 to 2014, with a focus on relationships driving factors. Our research indicates that emission intensity structures at first showed an increasing trend, which then decreased. Furthermore, relationship between economic growth has been trending toward absolute decoupling....
Microtubule plays many different essential roles in the process of tumorigenesis eukaryotes, and targeting mitotic progression by disturbing microtubule dynamics is used as a common strategy for cancer treatment. Microtubule-targeted drugs, including paclitaxel <i>Vinca</i> alkaloids, were previously considered to work primarily increasing or decreasing cellular mass. The tubulin/microtubule system, which an integral component cytoskeleton, therapeutic target prostate cancer. In this study,...
Aim: The first inhibitor targeting myoferlin (MYOF), WJ460, bears poor metabolic stability and water solubility. Therefore, this study aimed to improve the drug-like properties of WJ460. Materials & methods: authors synthesized an array 1,5-diaryl-1,2,4-triazole analogs appraised binding activities with MYOF their antiproliferative antimigratory against pancreatic cancer cells. Results: Molecular docking surface plasmon resonance results showed that E4 was directly bound MYOF-C2D domain....
With increasing acceptance of premarital sex among young Chinese women, the rates unintended pregnancies and induced abortions are becoming alarmingly high, suggesting needs educating women with adequate contraceptive knowledge providing them accessible services. Previous studies have shown that attitudes towards contraception could be modified through intervention strategies. This study aimed to evaluate effects two community models on modifying behaviors nulliparous women. In this...