A5100449115- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Crop Yield and Soil Fertility
- Plant Gene Expression Analysis
- interferon and immune responses
- Plant Stress Responses and Tolerance
- Plant Molecular Biology Research
- Circular RNAs in diseases
- Pharmacological Effects of Natural Compounds
- Animal testing and alternatives
- Forensic Entomology and Diptera Studies
- Human Mobility and Location-Based Analysis
- Privacy, Security, and Data Protection
- Complex Network Analysis Techniques
- MicroRNA in disease regulation
- Drug-Induced Hepatotoxicity and Protection
- Cell death mechanisms and regulation
- Ginseng Biological Effects and Applications
- Insect Utilization and Effects
- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Insect and Pesticide Research
- Natural Antidiabetic Agents Studies
- Nitrogen and Sulfur Effects on Brassica
First Affiliated Hospital of Zhengzhou University
2022-2024
State Grid Corporation of China (China)
2024
Xinxiang Medical University
2024
Tianjin Medical University
2017-2024
Tianjin First Center Hospital
2017-2024
Southwest Medical University
2024
Fujian Medical University
2022-2023
Liaoning Normal University
2018-2023
Edinburgh Cancer Research
2023
Shandong First Medical University
2022
Ferroptosis has important value in cancer treatment. It is significant to explore the new ferroptosis-related lncRNAs prediction model Hepatocellular carcinoma (HCC) and potential molecular mechanism of lncRNAs. We constructed a prognostic multi-lncRNA signature based on differentially expressed HCC. qRT-PCR was applied determine expression lncRNA HCC cells. The biological roles NRAV vitro vivo were determined by performing series functional experiments. Furthermore, dual-luciferase reporter...
The NAC (NAM, ATAF1/2, and CUC2) transcription factors are one of the largest families in plants play an important role plant development response to adversity. In this study, we cloned a new gene, SlNAC10, from halophyte Suaeda liaotungensis K. gene has total length 1584 bp including complete ORF 1107 that encodes 369 amino acids. SlNAC10-GFP fusion protein is located nucleus SlNAC10 activation structural domain at C-terminus. We studied expression characteristics found it was highest...
The NAC (NAM, ATAF1/2 and CUC2) transcription factors are ubiquitously distributed in plants play critical roles the construction of plant organs abiotic stress response. In this study, we described cloning a Suaeda liaotungensis K. factor gene SlNAC4, which contained 1450 bp, coding 331 amino acid. We found that SlNAC4 was highly expressed stems S. liaotungensis, expression considerably up-regulated after salt, drought, ABA treatments. Transcription analysis subcellular localization...
Piperlongumine is an alkaloid compound extracted from Piper longum L. It a chemical substance with various pharmacological effects and medicinal value, including anti‑tumor, lipid metabolism regulatory, antiplatelet aggregation analgesic properties. The present study aimed to understand whether piperlongumine induces the apoptosis autophagy of leukemic cells, identify mechanism involved. Cell viability were detected using MTT, phenazine methyl sulfate trypan blue exclusion assays. rate was...
Methotrexate (MTX), an anti-metabolite agent, is a widely used chemotherapeutic anticancer drug, but its hepatotoxicity severely limits clinical application. Nevertheless, the precise mechanisms of MTX-caused liver damage are extremely intricate and still need to be fully clarified. In current study, we investigated role STING-ERS-ferroptosis axis in MTX-triggered hepatic toxicity vivo vitro models. Male C57BL/6 J mice exposed single dose MTX (0, 2, 5, 20 mg/kg) for 3 days exhibited severe...
Jujuboside B (JuB) is the main bioactive saponin component of Chinese anti-insomnia herbal medicine Ziziphi Spinosae Semen, which has been reported to possess varied pharmacological functions. Even though it traditionally used treat inflammation- and toxicity-related diseases, effects JuB on acetaminophen (APAP) overdose-induced hepatotoxicity have not determined yet.
Gallbladder cancer (GBC) is the most common and aggressive malignancy of biliary tract. Betulinic acid (BetA) has been reported to have anti-inflammatory antitumor effects; however, effect BetA on GBC still unknown. In this study, we investigated five cell lines found that significantly inhibited proliferation NOZ cells but had little inhibitory other cells. disturbed mitochondrial membrane potential induced apoptosis in Real-time polymerase chain reaction analysis revealed stearoyl-coenzyme...
Death receptor-mediated extrinsic apoptosis system had been developed as a promising therapeutic strategy in clinical oncology, such TRAIL therapy. However, multiple studies have demonstrated that resistance is the biggest problem for disappointing trials despite preclinical success. Targeting cellular FLICE inhibitory protein (cFLIP) one of combinatorial therapies to overcome DR-mediated due its negative regulator apoptosis. E × 527 (Selisistat) specific inhibitor SIRT1 activity with safe...
Metastasis is the primary cause of high mortality rates in head and neck squamous cell carcinoma (HNSCC). MicroRNA (miR)‑411‑5p has been discovered to serve an important role cancer metastases. However, best our knowledge, association between miR‑411‑5p expression levels HNSCC metastasis not thoroughly investigated. The present study aimed research function metastasis. results revealed that were upregulated patients with lymph node positively associated metastatic potential HNSCC. Moreover,...
Diabetic ulcer (DU) has been recognized as one of the most prevalent and serious complications diabetes. However, clinical efficacy standard treatments for DU remains poor. Traditional Chinese medicine (TCM) shows a positive therapeutic effect on DU. Specifically, Zizhu ointment (ZZO) widely used to treat in long-term practice, but exact mechanism by which it promotes wound healing unknown. In this study, network analysis high-performance liquid chromatography-high resolution mass...
<title>Abstract</title> Nasal myiasis is a nasal infestation caused by parasitizing on the cavity, rare parasitic disease. The cavity close to sinuses, eyes, and cranial once fly larvae migrate into this location, it may lead serious consequences. Timely effective removal of maggots proper treatment can effectively avoid further deterioration Here, we describe 55 year-old woman admitted intensive care unit (ICU) with severe respiratory failure. On 4<sup>th</sup> day after admission, patient...
Nasal myiasis is a nasal infestation caused by myiasis, parasitic disease affecting the cavity. It rare condition. The cavity in close proximity to sinuses, eyes, and cranial If fly larvae migrate into this location, it may result significant complications. prompt appropriate removal of maggots administration an efficacious treatment can effectively prevent further deterioration disease. In case study, we present 55-year-old woman who was admitted intensive care unit with severe respiratory...
<title>Abstract</title> Purpose Hepatocellular carcinoma (HCC) is the third leading cause of cancer related death, and its molecular mechanisms have not been fully elucidated. The aim this work to discover association between immune microenvironment changes pyroptosis in HCC. Methods Select gene expression profiles from comprehensive database, establish protein-protein interaction networks, perform functional enrichment analysis using databases such as Kyoto Encyclopedia Genes Genomes...
Ice shedding from heavily iced transmission lines frequently causes significant vertical vibration responses, which may result in damage to structures and line flashovers. Most existing research on conductor jump behavior after ice focuses predominantly events alone, without considering the influence of wind during process. This paper introduces a finite element approach assess dynamic conductors under combined effects ice-shedding. A typical two-bundled with bridges serves as subject for...
AIM:To study on the association of lnc-MEG3/miR-181b and UCH-L1 in progression cerebral hemorrhage.Further facilitation development novel strategies that use their potential as a therapeutic targets. MATERIAL METHODS:In this study, we studied lncRNA MEG3 miR-181b expression 30 patients with ICH who were admitted to General Hospital Xinjiang Military Command from January 2021 May by quantitative polymerase chain reaction.Serum levels detected enzyme-linked immune sorbent assay, disease...
<title>Abstract</title> <bold>Background:</bold> Ferroptosis has important value in cancer treatment. It is significant to explore the new Ferroptosis-related lncRNA prediction model Hepatocellular carcinoma (HCC) and potential molecular mechanism.<bold>Methods: </bold>We constructed a prognostic multilncRNA signature based on ferroptosis-related differentially expressed lncRNAs HCC. qRT-PCR was applied determine expression of HCC cells tissues. The biological roles NRAV vitro vivo were...
<title>Abstract</title> Ferroptosis has important value in cancer treatment. It is significant to explore the new ferroptosis-related lncRNAs(FRLs) prediction model Hepatocellular carcinoma (HCC) and potential molecular mechanism of lncRNAs.<bold> </bold>We constructed a prognostic multi-lncRNA signature based on differentially expressed lncRNAs HCC. qRT-PCR was applied determine expression lncRNA HCC cells. The biological roles NRAV vitro vivo were determined by performing series functional...
Abstract Two key characteristics of senescent cells are nucleolar fusion and secretion a plethora pro-inflammatory cytokines called the senescence-associated secretory phenotype (SASP). The SASP is dependent on NF-κB but initial trigger, links with nucleoli, unclear. Using multiple in vitro vivo models, we show that an early response to oncogene- therapy-induced senescence (OIS TIS) nuclear/nucleolar accumulation PolI complex component, TIF-IA. This essential for fusion, senescence,...
<title>Abstract</title> Ferroptosis has essential value in cancer treatment. It is significant to explore the new ferroptosis-related lncRNAs(FRLs) prediction model Hepatocellular carcinoma (HCC) and potential molecular mechanism of lncRNAs.<bold> </bold>Using differentially expressed lncRNAs associated with ferroptosis, we developed A multi-lncRNA prognostic signature HCC. We used qRT-PCR detect lncRNA HCC cells. performed functional experiments vitro vivo determine biological role NRAV....