A5028115272- Cell death mechanisms and regulation
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Toxin Mechanisms and Immunotoxins
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Plant Disease Resistance and Genetics
- Endoplasmic Reticulum Stress and Disease
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- Cancer-related gene regulation
- DNA Repair Mechanisms
- Berberine and alkaloids research
- RNA modifications and cancer
- Lung Cancer Research Studies
- Online Learning and Analytics
- Wnt/β-catenin signaling in development and cancer
- Chromatography in Natural Products
- Genomics, phytochemicals, and oxidative stress
- Ginseng Biological Effects and Applications
- Silicon Effects in Agriculture
Shandong First Medical University
2019-2024
Affiliated Hospital of Taishan Medical University
2022-2024
University Hospital of Basel
2021
Chengdu Neusoft University
2021
Neusoft (China)
2021
The 309th Hospital of Chinese People's Liberation Army
2020
Taishan Medical University
2011-2018
Anticancer strategies using natural products or derivatives are promising alternatives for cancer treatment. Here, we showed that licochalcone D (LCD), a flavonoid extracted from Glycyrrhiza uralensis Fisch, suppressed the growth of breast cells, and was less toxic to MCF-10A normal cells. LCD-induced DNA damage, cell cycle arrest, apoptosis in Furthermore, LCD potentiated tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cytotoxicity. Mechanistically, revealed reduce...
Although temozolomide (TMZ) is the most effective chemotherapy agent for glioma, resistance has limited its clinical use. Fluoxetine (FLT), which widely used in cancer-related depression, exhibited potent anticancer properties different cancer cell types. The aim of this study was i) to evaluate antitumor mechanism FLT, and ii) further effects a combination FLT TMZ on glioma cells. Glioma lines were exposed and/or TMZ. Cell viability apoptosis examined by CCK-8 assay, flow cytometry...
Abstract Objective: The current study aimed to investigate the functional roles and clinical significance of microRNA-148a (miR-148a) in progression oral squamous cell carcinoma (OSCC). Methods: Relative expression miR-148a OSCC cells tissues were detected using quantitative real-time polymerase chain reaction (qRT-PCR). Chi-square test was performed estimate relationship between characteristics patients. Cell transfection carried out Lipofectamine® 2000. Biological behaviors tumor...
To maintain the integrity of genome, cells need to detect and repair DNA damage before they complete cell division. Hepatitis B x-interacting protein (HBXIP), a binding HBx (Hepatitis virus × protein), is aberrantly overexpressed in human cancer show promote proliferation inhibit apoptosis. The present study designed investigate role HBXIP on response. Our results that acts as an important regulator G2/M checkpoint response damage. knockdown increases phospho-histone H2AX expression foci...
Abstract Daurisoline (DS) is an isoquinoline alkaloid that exerts anticancer activities in various cancer cells. However, the underlying mechanisms through which DS affects survival of breast cells remain poorly understood. Therefore, present study was undertaken to investigate potential effect on and reveal mechanism enhanced tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL)‐mediated apoptosis by DS. Cell counting kit‐8 (CCK‐8) 5‐ethynyl‐2‐deoxyuridine (EdU) assay were used...
Osteosarcoma is a highly invasive primary malignant bone tumor. PI3K/mTOR pathway plays key role in tumor progression, and inhibition of represents novel strategy therapy osteosarcoma. CCT128930 VS5584 are both inhibitors PI3K/mTOR, but the anticancer mechanism or/and against human osteosarcoma cells remains unclear. Herein, U2OS MG63 were cultured, effects alone combined effect explored. The results showed that as inhibitor effectively inhibited p-p70 p-AKT expression dose-dependently...
Oral squamous cell carcinoma (OSCC) is the most common malignant epithelial tumor in oral cavity. Emerging evidence has demonstrated important function roles of long noncoding RNAs (lncRNAs) human cancers. LncRNA promoter CDKN1A antisense DNA damage activated RNA (PANDAR) functions as an oncogene multiple carcinomas, whereas its OSCC not been investigated yet. The aim our study to investigate possible regulatory mechanism PANDAR OSCC. First all, was highly expressed cells and...
Activation of the PI3K/mTOR signaling pathway plays a key role in progression human osteosarcoma. Studies have confirmed that VS-5584 was novel inhibitor pathway, and displayed potential anticancer activity.To explore effect underlying mechanism against growth osteosarcoma cells.U2OS MG-63 cells were cultured cytotoxicity, cell apoptosis VS-5584-treated explored by CCK8 assay, flow cytometric analysis western blot. Cell migration tube formation also employed to examine potential.The results...
With the rapid development of multimedia technology, student centered flipped classroom model (FCM) and massive open online courses (MOOCs) have been increasingly introduced implemented in higher medical education. However, comparative analyses offline face-to-face FCM completely rarely reported. In this study, we focused specifically on a set classrooms which prerecorded videos were provided before class. Using Zhihuishu platform as major course platform, our team built MOOC evaluated...
NOTICE OF RETRACTION: While investigating potential publication-related misconduct in connection with the ICIMTech 2021 Conference Proceedings, serious concerns were raised that cast doubt on integrity of peer-review process and all papers published Proceedings this Conference. The entire has been called into question. As a result, its investigation, ACM decided to retract Entire related from Digital Library.