A5026791731- CAR-T cell therapy research
- Protein Tyrosine Phosphatases
- Inflammatory Biomarkers in Disease Prognosis
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Atrial Fibrillation Management and Outcomes
- Galectins and Cancer Biology
- Blood Pressure and Hypertension Studies
- Immunotherapy and Immune Responses
- Acute Myeloid Leukemia Research
- Cardiovascular Health and Disease Prevention
- Reproductive tract infections research
- Pregnancy and preeclampsia studies
- Cytomegalovirus and herpesvirus research
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Cardiac Health and Mental Health
- Gestational Diabetes Research and Management
- Dermatology and Skin Diseases
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Hormonal Regulation and Hypertension
- Acute Ischemic Stroke Management
- Cell death mechanisms and regulation
Tianjin Medical University General Hospital
2010-2025
Weifang Medical University
2025
Weifang People's Hospital
2025
Guangdong Academy of Medical Sciences
2017-2025
Guangdong General Hospital
2017-2025
Monash University
2023-2024
Peter MacCallum Cancer Centre
2019-2024
Beijing Anzhen Hospital
2010-2024
Capital Medical University
2010-2024
Sun Yat-sen Memorial Hospital
2024
Article5 December 2019Open Access PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy solid tumours Florian Wiede orcid.org/0000-0001-5145-7180 Monash Biomedicine Discovery Institute, University, Clayton, Vic., Australia Department of Biochemistry Molecular Biology, Peter MacCallum Cancer Centre, Melbourne, Search for more papers by this author Kun-Hui Lu Xin Du Sir Oncology, The University Shuwei Liang Katharina Hochheiser Microbiology Immunology,...
Abstract Immunotherapies aimed at alleviating the inhibitory constraints on T cells have revolutionized cancer management. To date, these focused blockade of cell-surface checkpoints such as PD-1. Herein we identify protein tyrosine phosphatase 1B (PTP1B) an intracellular checkpoint that is upregulated in tumors. We show increased PTP1B limits T-cell expansion and cytotoxicity to contribute tumor growth. cell–specific deletion STAT5 signaling, this enhanced antigen-induced CD8+ suppress The...
Abstract The inhibition of protein tyrosine phosphatases 1B (PTP1B) and N2 (PTPN2) has emerged as an exciting approach for bolstering T cell anti-tumor immunity. ABBV-CLS-484 is a PTP1B/PTPN2 inhibitor in clinical trials solid tumors. Here we have explored the therapeutic potential related small-molecule-inhibitor, Compound-182. We demonstrate that Compound-182 highly potent selective active site competitive PTP1B PTPN2 enhances recruitment activation represses growth tumors mice, without...
Baicalin, extracted and purified from the Chinese medicinal plant, Scutellaria baicalensis Georgi (Huang qin in Chinese), exhibits potent anti-inflammatory activity against asthma. However, it remains unknown whether baicalin inhibits of CC chemokine receptor 7 (CCR7) its ligands, which are crucial for initiation airway inflammation. In present study, we investigated effects on CCR7 CCL19 CCL21, as well nuclear factor-κB (NF-κB) pathway a mouse model A acute asthma was established by...
Perineural invasion (PNI) leads to the poor prognosis of head and neck squamous cancer (HNSCC) patients, but mechanism PNI remains unclear. Dickkopf-1 (DKK1), a secretory protein in Wnt signaling pathway, was found indeed upregulated HNSCC cells tissues. Higher expression DKK1 statistically relevant T stage, N PNI, HNSCC. overexpression enhanced migration abilities cells. Moreover, DKK1-overexpressing promoted peripheral nerves vitro vivo. Mechanistically, could promote PI3K–AKT pathway. The...
Gestational diabetes mellitus (GDM) seriously endangers the health of pregnant women and their offspring. Early prediction diagnosis allow timely treatment GDM, preventing adverse pregnancy outcomes related diseases. This research aims to explore predictive significance miR-486-3p expression levels in diagnosing GDM early pregnancy. A retrospective study was conducted by enrolling 103 subjects with 98 healthy subjects. qRT-PCR used analyze level miR-486-3p. The chi-square test t-test were...
Abstract Purpose: In this article, we describe a combination chimeric antigen receptor (CAR) T-cell therapy that eradicated the majority of tumors in two immunocompetent murine pancreatic cancer models and human xenograft model. Experimental Design: We used dual-specific CAR T cell expresses against Her2 tumor antigen, (TCR) specific for gp100. As gp100 is also known as pMEL, cells are thus denoted CARaMEL cells. A vaccine containing live vaccinia virus coding minigene (VV-gp100) was...
Objective . Both hypertension and subclinical thyroid dysfunction (STD) have high prevalence clinical importance, but their relationship is still a matter of debate. We aimed to explore gender-specific difference on the association between STD in Chinese. Methods recruited 13,380 ostensible healthy participants (8,237 men 5,143 women). The associations were analyzed gender-based setting after dividing into hypothyroidism, hyperthyroidism further subgrouped euthyroidism. Crude adjusted odds...
Adoptive cell therapy with chimeric antigen receptor (CAR) T cells has revolutionized the treatment of certain B malignancies but been in ineffective against solid tumors. Recent studies have highlighted potential targeting negative regulators signaling to enhance efficacy and extend utility CAR Autoimmunity-linked protein tyrosine phosphatase N22 (PTPN22) proposed as a target for cancer immunotherapy. Here, we used CRISPR/Cas9 gene editing generate PTPN22-deficient (Ptpn22Δ/Δ) mice...
Association of stroke risk with new blood pressure criterion 2017 is unknown in China. We assessed the association between (BP) values and a low-income population Tianjin, Systolic (SBP) diastolic (DBP) were categorized into five strata strokes recorded as stroke, ischemic hemorrhagic stroke. Stroke was analyzed according to stratum using Cox regression analysis. Overall, 4,017 residents (age, ≥18 years) included this prospective cohort study. Over 27-year follow-up period (total, 86,515.78...
Autogenous tooth transplantation is a reliable method for repairing missing teeth. Although it recently became recognized and feasible treatment in dentistry, the long-term efficacy of root canal therapy (RCT) has not been well confirmed. This study aimed at determining whether RCT good effect on success rate teeth with complete roots autogenous transplantation.Data were collected from Korea University Guro Hospital. Data patients who underwent within 9 years collected. We selected 29 as...
Background Dysfunction of central and skin Hypothalamic-Pituitary-Adrenal (HPA) axis play important roles in pathogenesis atopic dermatitis (AD). Our previous studies showed that several Chinese herbs could improve HPA function. In this study, we evaluated the anti-inflammatory effects BuShenYiQi granule (BSYQ), a formula, AD mice explored effective mechanism from regulation axis. Methods The ovalbumin (OVA) induced model were established treated with BSYQ. We score histology analysis dorsal...
Inferior mechanical properties have always been a limitation of the bioresorbable membranes in GBR/GTR. This study is aimed at fabricating magnesium-reinforced polylactic acid- (PLA-) integrated membrane and investigating its properties, degradation rate, biocompatibility. The uncoated fluoride-coated magnesium alloys, AZ91, were made into strips. Then, PLA-integrated was through integration. PLA strips used control group instead Specimens cut rectangular shape immersed Hank’s Balanced Salt...
There is an increasing trend of skipping meals, especially breakfast and dinner, in China. Previous studies on the association meal with lipid profiles blood glucose have yielded inconsistent results.A national representative survey 47 841 adults (age ≥ 45 y) was conducted Frequency breakfast, lunch, dinner consumption were assessed a questionnaire. Blood triacylglycerols, total cholesterol, high-density lipoprotein low-density fasting measured using standard methods. Generalized linear...
The purpose of this study was to compare the clinicopathological characteristics type 1 and 2 papillary renal cell carcinoma (PRCC) explore prognostic factors PRCC in Chinese population.A total 242 patients with from five medical centers were retrospectively included. From them, 82 160 PRCC. Clinicopathological features oncologic outcomes reviewed. Kaplan-Meier analysis log-rank test performed describe progression-free survival (PFS) overall (OS). Univariate multivariate Cox proportional...
Limit order books (LOBs) have generated big financial data for analysis and prediction from both academic community industry practitioners. This article presents a benchmark LOB dataset the Chinese stock market, covering few thousand stocks period of June to September 2020. Experiment protocols are designed model performance evaluation: at end every second, forecast upcoming volume-weighted average price change volume over 12 horizons ranging 1 second 300 seconds. Results based on linear...
Despite advances in the treatment of T‑cell acute lymphoblastic leukemia (T‑ALL), outcome T‑ALL remains unsatisfactory, therefore, more effective is urgently required. The present study examined cytotoxicities bortezomib combination with daunorubicin against human Jurkat and Molt‑4 cells primary cells. Compared alone, co‑exposure to resulted a significant increase cell death cells, as evidenced by increased percentage Annexin V‑positive formation apoptotic bodies. In addition, administration...