A5000389818- Head and Neck Cancer Studies
- Thyroid and Parathyroid Surgery
- Cancer Immunotherapy and Biomarkers
- Voice and Speech Disorders
- Tracheal and airway disorders
- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Quantum Information and Cryptography
- Dysphagia Assessment and Management
- Teratomas and Epidermoid Cysts
- Medical Research and Treatments
- Integrated Energy Systems Optimization
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Parathyroid Disorders and Treatments
- Caching and Content Delivery
- Smart Grid Energy Management
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced Data Storage Technologies
- Respiratory and Cough-Related Research
- Electric Vehicles and Infrastructure
- Advanced Proteomics Techniques and Applications
- Mass Spectrometry Techniques and Applications
Sun Yat-sen Memorial Hospital
2016-2025
Sun Yat-sen University
2016-2025
Xiamen University
2023-2024
Key Laboratory of Guangdong Province
2022-2024
University of Science and Technology of China
2022-2024
University of Chinese Academy of Sciences
2023-2024
Changchun University of Technology
2018-2023
Tianjin Fourth Central Hospital
2021
Nankai University
2021
State Key Laboratory of Pollution Control and Resource Reuse
2019
Given the important advantages of mid-infrared optical range (2.5 to 25 μm) for biomedical sensing, communications, and molecular spectroscopy, extending quantum information technology this region is highly attractive. However, development still in its infancy. Here, we report on generation a time-energy entangled photon pair wavelength band. By using frequency upconversion detection technology, observe two-photon Hong-Ou-Mandel interference demonstrate entanglement between twin photons at...
Interferon-stimulated gene 15 (ISG15) is known to be involved in tumor progression. We previously reported that ISG15 expressed on nasopharyngeal carcinoma (NPC) cells and related poor prognosis of patients with NPC. further observed can secreted by NPC cell the macrophages situ. However, role tumor-associated (TAMs) remains poorly understood. In present study, we found treatment induces M2-like phenotype, enhancement migration tumorigenicity. Mechanically, ISG15-induced phenotype dependent...
Perineural invasion (PNI) leads to the poor prognosis of head and neck squamous cancer (HNSCC) patients, but mechanism PNI remains unclear. Dickkopf-1 (DKK1), a secretory protein in Wnt signaling pathway, was found indeed upregulated HNSCC cells tissues. Higher expression DKK1 statistically relevant T stage, N PNI, HNSCC. overexpression enhanced migration abilities cells. Moreover, DKK1-overexpressing promoted peripheral nerves vitro vivo. Mechanistically, could promote PI3K–AKT pathway. The...
Head and neck squamous cell carcinoma (HNSCC) is a very common type of head cancer, the 5-year overall survival (OS) rate only 50%. Inhibitors targeting programmed death 1 (PD-1) pathway have gained widespread clinical adoption. However, relationship between infiltration characteristics immune cells in tumor microenvironment (TIME) effect immunotherapy on HNSCC remains to be explored. Patients diagnosed with who received Tislelizumab combined chemotherapy were reviewed February 2021 March...
Recently, chimeric transcripts have been found to be associated with the pathogenesis and poor prognosis of malignant tumors. Through our preliminary experiment, a novel transcript called RRM2-c2orf48 was detected in C666-1, classical cell line human nasopharyngeal carcinoma (NPC). Therefore, objective this study demonstrate existence expression explore main functions mechanisms NPC. In study, evaluated NPC cells specimens. Effects on migration invasive capacities were vivo vitro. Moreover,...
The present study was designed to retrospectively evaluate the prognostic value of C-reactive protein/albumin (CRP/ALB) ratio in laryngeal squamous cell carcinoma (LSCC).One hundred and twenty-nine newly diagnosed LSCC patients admitted between May 2006 October 2011 were reviewed. Their serum CRP ALB quantified preoperatively. relationship CRP/ALB clinicopathologic features analyzed. Receiver operating characteristic curve used calculate ratio. Then, Cox proportional hazards model univariate...
Distant metastasis remains the major cause for treatment failure in patients with nasopharyngeal carcinoma (NPC). Thus, it is necessary to investigate underlying regulation mechanisms and potential biomarkers NPC metastasis. Nogo-B (neurite outgrowth inhibitor B), encoded by reticulon-4, has been shown be associated progression advanced stage of several cancer types. However, relationship between unknown. In this study, we found that higher expression was detected cells tissues. Higher...
Proteomics provides molecular bases of biology and disease, liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a platform widely used for bottom-up proteomics. Data-independent acquisition (DIA) improves the run-to-run reproducibility LC-MS/MS in proteomics research. However, existing DIA data processing tools sometimes produce large deviations from true values peptides proteins quantification. Peak-picking error incorrect ion selection are two main causes deviations. We present...
Abstract Background To date, although most thyroid carcinoma (THCA) achieves an excellent prognosis, some patients experience a rapid progression episode, even with differentiated THCA. Nodal metastasis is unfavorable predictor. Exploring the underlying mechanism may bring deep insight into Methods A total of 108 THCA from Chinese next-generation sequencing (NGS) were recruited. It was used to explore gene alteration spectrum and identify alterations related nodal in papillary (PTC). The...
Cancer-associated fibroblasts (CAFs) are the primary stromal cells found in tumor microenvironment, and display high plasticity heterogeneity. By using single-cell RNA-seq technology, researchers have identified various subpopulations of CAFs, particularly highlighting a recently subpopulation termed antigen-presenting CAFs (apCAFs), which largely unknown.
An ellipsometer is a vital precision tool used for measuring optical parameters with wide applications in many fields, including accurate measurements film thickness, constants, structural profiles, etc. However, the precise measurement of photosensitive materials meets huge obstacles because excessive input photons, therefore requirement enhancing detection accuracy under low incident light intensity an essential topic measurement. In this work, by combining polarization-entangled photon...
Data-independent acquisition (DIA) has improved the identification and quantitation coverage of peptides proteins in liquid chromatography–tandem mass spectrometry-based proteomics. However, different DIA data-processing tools can produce very results for same data set. Currently, benchmarking studies are predominantly focused on comparing results, while quantitative accuracy measurements is acknowledged to be important but insufficiently investigated, absence suitable metrics one reasons. A...
For patients with locally advanced head and neck squamous cell carcinoma (HNSCC), combined programmed death receptor-1 inhibitor chemotherapy improved response rate to neoadjuvant therapy. However, treatment varies among patients. There is no tool predict pathologic complete (pCR) high accuracy for now. To develop a based on radiomics features of MRI pCR chemoimmunotherapy (NACI) may provide valuable assistance in regimen determination HNSCC.
Abstract Background Thyroglossal duct cysts (TDCs) are usually resected through an incision over the entire protruding zone. The resulting scar is aesthetically displeasing, so we explored use of endoscope‐assisted excision TDCs via a submaxillary vestibular approach. purpose this study was to demonstrate feasibility, validity, and safety approach evaluate follow‐up results. Methods From January 2007 August 2015, 16 patients with underwent surgical resection using Results All procedures were...