A5021781633- Gut microbiota and health
- Genomics and Phylogenetic Studies
- GaN-based semiconductor devices and materials
- Microbial Community Ecology and Physiology
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Semiconductor materials and devices
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Organ and Tissue Transplantation Research
- Silicon Carbide Semiconductor Technologies
- Animal Nutrition and Physiology
- Tissue Engineering and Regenerative Medicine
- Oral Health Pathology and Treatment
- Aquaculture disease management and microbiota
- Epigenetics and DNA Methylation
- Ga2O3 and related materials
- Oral microbiology and periodontitis research
- Invertebrate Immune Response Mechanisms
- Bioinformatics and Genomic Networks
- Probiotics and Fermented Foods
- Salivary Gland Disorders and Functions
- Adolescent and Pediatric Healthcare
- Acoustic Wave Resonator Technologies
- RNA modifications and cancer
Chinese Academy of Sciences
2015-2024
Harvard University
2019-2024
University of Chinese Academy of Sciences
2018-2024
Capital Medical University
2012-2024
Tianjin University of Technology
2024
Brigham and Women's Hospital
2019-2024
Institute of Genetics and Developmental Biology
2020-2024
Qingdao Institute of Bioenergy and Bioprocess Technology
2015-2023
Yantai University
2019-2023
Nanjing University of Chinese Medicine
2013-2023
Reducing antibiotics overuse in animal agriculture is one key combat against the spread of antibiotic resistance. Probiotics are a potential replacement feed; however, it not clear whether and how probiotics differ impact on physiology microbial ecology host animals.Host phenotype fecal microbiota broilers with either or as feed additive were simultaneously sampled at four time points from birth to slaughter then compared. Probiotic feeding resulted lower conversion ratio (FCR) induced...
Previous studies have discovered a lot of immune-related genes responding to white spot syndrome virus (WSSV) infection in crustacean. However, little information is available relation underlying mechanisms host responses during the WSSV acute stage naturally infected shrimp. In this study, we employed next-generation sequencing and bioinformatic techniques observe transcriptome differences shrimp between latent stage. A total 64,188,426 Illumina reads, including 31,685,758 reads from group...
Mastitis, which affects nearly all lactating mammals including human, is generally thought to be caused by local infection of the mammary glands. For treatment, antibiotics are commonly prescribed, however concern in both treatment efficacy and neonate safety. Here, using bovine mastitis most costly disease dairy industry as a model, we showed that intestinal microbiota alone can lead mastitis.
Abstract The number of metagenomes is increasing rapidly. However, current methods for metagenomic analysis are limited by their capability in-depth data mining among a large microbiome each which carries complex community structure. Moreover, the complexity configuring and operating computational pipeline also hinders efficient processing end users. In this work we introduce Parallel-META 3, comprehensive fully automatic toolkit rapid datasets, with advanced features including 16S rRNA...
We introduce a novel, high-speed Raman-activated cell sorter (pDEP-RADS) that screens enzymes in vivo.
Abstract Microbiome samples with low microbial biomass or severe DNA degradation remain challenging for amplicon-based whole-metagenome sequencing approaches. Here, we introduce 2bRAD-M, a highly reduced and cost-effective strategy which only sequences ~ 1% of metagenome can simultaneously produce species-level bacterial, archaeal, fungal profiles. 2bRAD-M accurately generate taxonomic profiles otherwise hard-to-sequence merely 1 pg total DNA, high host contamination, severely fragmented...
Massive microbiome sequencing data has been generated, which elucidates associations between microbes and their environmental phenotypes such as host health or ecosystem status. Outstanding bioinformatic tools are the basis to decipher biological information hidden under data. However, most approaches placed difficulties on accessibility nonprofessional users. On other side, computing throughput become a significant bottleneck of many analytical pipelines in processing large-scale datasets....
It has been widely recognized that a critical time window for neurodevelopment occurs in early life and the host's gut microbiome plays an important role neurodevelopment. Following recent demonstrations maternal prenatal influences offspring brain development murine models, we aim to explore whether association between is or postnatal human.Here leverage large-scale human study compare associations microbiota metabolites from mothers during pregnancy their children with children's...
Neural stem/progenitor cell (NSPC)-based spinal cord injury (SCI) therapy is expected to bridge the lesion site by transplanting exogenous NSPCs for replacement of lost cells.
The stable gut microbiome plays a key role in sustaining host health, while the instability of also has been found to be risk factor various metabolic diseases. At ecological and evolutionary scales, inevitable competition between ingested probiotic indigenous can lead an increase instability. It remains largely unclear if how exogenous prebiotic improve overall stability consumption. In this study, we used Lactobacillus plantarum HNU082 (Lp082) as model examine impact continuous or pulsed...
Spinal cord injury (SCI) leads to severe sensory and motor dysfunction below the lesion. However, cellular dynamic responses heterogeneity across different regions lesion remain be elusive. Here, we used single-cell transcriptomics investigate region-related in female rhesus monkeys with complete thoracic SCI from acute chronic phases. We found that distal lumbar tissue cells were severely impacted, leading degenerative microenvironments characterized by disease-associated microglia...
Spinal cord injury (SCI) causes tissue structure damage and composition changes of the neural parenchyma, resulting in severe consequences for spinal function. Mimicking components microstructure tissues holds promise restoring regenerative microenvironment after SCI. Here, we have utilized electrospinning technology to develop aligned decellularized fibers (A-DSCF) without requiring synthetic polymers or organic solvents. A-DSCF preserves multiple types extracellular matrix proteins forms a...
Abstract Accurate species identification and abundance estimation are critical for the interpretation of whole metagenome sequencing (WMS) data. Yet, existing metagenomic profilers suffer from false-positive identifications, which can account more than 90% total identified species. Here, by leveraging species-specific Type IIB restriction endonuclease digestion sites as reference instead universal markers or microbial genomes, we present a profiler, MAP2B ( M et A genomic P rofiler based on...
Abstract Spinal cord injury (SCI) leads to fibrotic scar formation at the lesion site, yet heterogeneity of remains elusive. Here we show in distribution, origin, and function fibroblasts within scars after SCI mice female monkeys. Utilizing lineage tracing single-cell RNA sequencing (scRNA-seq), found that perivascular (PFs), meningeal (MFs), rather than pericytes/vascular smooth cells (vSMCs), primarily contribute both transection crush SCI. Crabp2 + /Emb+ (CE-F) derived from meninges...
Curdione is a sesquiterpene isolated from Curcumae Rhizoma that possesses high biological activity and extensive pharmacological effects. As traditional Chinese medicine, can inhibit the development of many types cancer, especially colorectal cancer. However, anti-colorectal mechanism its monomer curdione remains unclear.Colorectal cancer (CRC) cells were treated with at doses 12.5 μM, 25 50 then cells' was measured methyl thiazolyl tetrazolium (MTT). Nude mice administered different...
Abstract Background Topologically associating domains (TADs) are considered the structural and functional units of genome. However, there is a lack an integrated resource for TADs in literature where researchers can obtain family classifications detailed information about TADs. Results We built online knowledge base TADKB integrating eleven cell types human mouse. For each TAD, provides predicted three-dimensional (3D) structures chromosomes TADs, annotations protein-coding genes long...