A5101699049- Gut microbiota and health
- Aquaculture disease management and microbiota
- Probiotics and Fermented Foods
- Neuroendocrine regulation and behavior
- Dietary Effects on Health
- Food composition and properties
- Plant-Microbe Interactions and Immunity
- Genetic Syndromes and Imprinting
- Mycobacterium research and diagnosis
- Circadian rhythm and melatonin
- Microbial Metabolites in Food Biotechnology
- Digestive system and related health
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Immune Cell Function and Interaction
- Plant Pathogens and Fungal Diseases
- Pancreatitis Pathology and Treatment
- Oral Health Pathology and Treatment
- Clostridium difficile and Clostridium perfringens research
- Ruminant Nutrition and Digestive Physiology
- Ginseng Biological Effects and Applications
- Eating Disorders and Behaviors
Hainan University
2019-2022
Hainan General Hospital
2021
Haikou City People's Hospital
2019
Although a few studies have investigated the intestinal microbiota of women with polycystic ovary syndrome (PCOS), functional and metabolic mechanisms microbes associated PCOS, as well potential microbial biomarkers, not yet been identified. To address this gap, we designed two-phase experiment in which performed shotgun metagenomic sequencing monitored parameters, gut-brain mediators, sex hormones PCOS patients. In first stage, identified an imbalance patients, observing that...
The stable gut microbiome plays a key role in sustaining host health, while the instability of also has been found to be risk factor various metabolic diseases. At ecological and evolutionary scales, inevitable competition between ingested probiotic indigenous can lead an increase instability. It remains largely unclear if how exogenous prebiotic improve overall stability consumption. In this study, we used Lactobacillus plantarum HNU082 (Lp082) as model examine impact continuous or pulsed...
Abstract Graves’ Disease is the most common organ-specific autoimmune disease and has been linked in small pilot studies to taxonomic markers within gut microbiome. Important limitations of this work include sample sizes low-resolution markers. Accordingly, we studied 162 microbiomes mild severe (GD) patients healthy controls. Taxonomic functional analyses based on metagenome-assembled genomes (MAGs) MAG-annotated genes, together with predicted metabolic functions metabolite profiles,...
Melatonin has been widely used as a “probiotic agent” capable of producing strong neurotransmitter secretion regulatory effects, and the microbiota-gut-brain axis-related studies have also highlighted role gut microbiota in neuromodulation. In present study, zebrafish neural hyperactivity model was established using caffeine induction to explore effects melatonin probiotic on disorder zebrafish. Disorders brain (dopamine, γ-aminobutyric acid, 5-hydroxytryptamine) caused by were improved...
Abstract Graves’ disease (GD) is an autoimmune disorder that frequently results in hyperthyroidism and other symptoms. Here, we designed a 6-month study with patients divided into three treatment groups, namely, methimazole (MI, n = 8), MI + black bean ( 9) probiotic Bifidobacterium longum 9), to evaluate the curative effects of probiotics supplied on thyroid function GD through clinical index determination intestinal microbiota metagenomic sequencing. Unsurprisingly, intake significantly...
Abstract Background Numerous studies have reported the health-promoting effects of exopolysaccharides (EPSs) in vitro models; however, a functional evaluation EPSs will provide additional knowledge EPS-microbe interactions by vivo intestinal microbial model. In present study, high-throughput amplicon sequencing, short-chain fatty acid (SCFAs) and inflammation were performed to explore potential benefits EPS-producing Lactobacillus (HNUB20 group) using healthy zebrafish ( Danio rerio )...
Approximately 17 million people suffer from cardiovascular diseases caused by hyperlipidemia, making it a serious global health concern. Among others, resistant starch (RS) has been widely used as prebiotic in managing hyperlipidemia conditions. However, some studies have reported limited effects of RS on body weight and blood lipid profile the host, suggesting further investigation synergistic combination with probiotics gut microbes plays role metabolism. This study evaluated jackfruit...
Potassium sorbate (PS) is a class of bacteriostatic antiseptic agent widely used in the food industry; effects its intake on host health are currently unclear.
Intestinal microbiota performed numerous important functions during digestion. The first filial generation (F1) hybrids of Hainan black goats and Saanen had different traits, (BG) white (WG), which also brought production performance. We explored the difference gut between that both belonged to hybrids. In general, alpha diversity goat group was significantly higher than group. species richness no significant difference, while evenness BG WG. Bacteroides, Oscillospira, Alistipes,...
As an important economic crop in tropical areas, Areca catechu L. affects the livelihood of millions farmers. The yellow leaf phenomenon (AYLP) leads to severe losses and plant death. To better understand relationship microbes chlorotic leaves, microbial community structure as well its correlation with differential metabolites was investigated by high-throughput sequencing metabolomic approaches. High-throughput internal transcribed spacer 1 16S rRNA gene revealed that fungal diversity...
Abstract Background : Graves’ Disease (GD) is the most common organ-specific autoimmune disease and has been linked in small pilot studies to taxonomic markers within gut microbiome. However, sample size limited resolution of 16S rRNA amplicon sequencing technology universality significance these studies. Larger cohorts integration different levels analysis from high-resolution shotgun metagenomics data were therefore needed explore GD patients’ alteration microbial taxonomy, genes, pathways...
Abstract Background : Melatonin has been widely used as a "probiotic agent" capable of producing strong neurotransmitter secretion regulatory effects. In the present study, zebrafish neural hyperactivity model was established using caffeine induction, and regulation mechanism melatonin probiotic on disorder were explored. Results Disorders brain caused by caffeine, including that dopamine (DA), γ-aminobutyric acid (γ-GABA), 5-hydroxytryptamine (5-HT), improved after interference treatment...
Abstract Background : Melatonin has been widely used as a "probiotic agent" capable of producing strong neurotransmitter secretion regulatory effects. The probiotics related researches also provide the evidence microbial interactions with gut-brain axis for mental health. In present study, zebrafish neural hyperactivity model was established using caffeine induction, and regulation mechanism melatonin probiotic on disorder were explored. To further address challenge that if gut microbes play...