A5046223262- Drug Transport and Resistance Mechanisms
- Sphingolipid Metabolism and Signaling
- Cytokine Signaling Pathways and Interactions
- Glycosylation and Glycoproteins Research
- Chronic Myeloid Leukemia Treatments
- Estrogen and related hormone effects
- TGF-β signaling in diseases
- Molecular Biology Techniques and Applications
- Renal cell carcinoma treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic and rare skin diseases.
- Entomopathogenic Microorganisms in Pest Control
- T-cell and B-cell Immunology
- Ferroptosis and cancer prognosis
- Geophysics and Gravity Measurements
- Cancer and Skin Lesions
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Neonatal Health and Biochemistry
- Hedgehog Signaling Pathway Studies
- Respiratory viral infections research
- Neuroblastoma Research and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cytomegalovirus and herpesvirus research
- Asthma and respiratory diseases
Chongqing University
2024-2025
Wuxi People's Hospital
2013-2024
Nanjing Medical University
2013-2024
Wuxi Institute of Technology
2014-2019
First Hospital of Shanxi Medical University
2007
Shanxi Medical University
2007
Wuxi No.2 People's Hospital
2007
To date, the molecular mechanism underlying constitutive signal transducer and activator of transcription 3 (STAT3) activation in gliomas is largely unclear. In this study, we report that Smad6 overexpressed nuclei glioma cells, which correlates with poor patient survival regulates STAT3 activity via negatively regulating Protein Inhibitors Activated (PIAS3). Mechanically, interacts directly PIAS3, interaction mediated through Mad homology 2 (MH2) domain Ring PIAS3. recruits Smurf1 to...
Although an association between obesity and the occurrence of renal cell carcinoma (RCC) has been identified, mechanism by which functions to increase this risk cancer remains unclear. Leptin, visfatin, apelin, resistin adiponectin are peptide hormones secreted adipocytes; it is considered that these may affect RCC development exerting effects on proliferation, growth inflammation. The aim present study was investigate aforementioned adipokine genes clear (CC-RCC). GSE6344 dataset downloaded...
<i>Background:</i> Genistein, a flavonoid in legumes and some herbal medicines, has various biological actions. Previous studies have shown that genistein decreased airway inflammation allergic asthma. However, on how affects immunoreactions asthma are very limited. <i>Objective:</i> It was the aim of this study to investigate effect T helper 1 (Th1)/Th2 cytokines murine model explore its underlying mechanisms. <i>Methods:</i> The set up both vivo vitro:...
Entomopathogenic fungi represent a valuable natural resource with significant potential as biological agents for pest management. However, different species or strains of demonstrate varying effectiveness against specific targets. In this study, we assessed the impact two fungal strains, Beauveria bassiana KN801 and KN802, on rice planthoppers Ninaparvata lugens Sogatella furcifera, in combination insecticides. Our findings indicate that both B. can effectively infect nymphs adults N. S....
Idiopathic pulmonary fibrosis (IPF) is a rare, progressive, and lethal interstitial lung disease with unknown etiology. Divergent observations have suggested that genetic factors contribute to IPF susceptibility. This study investigated the relationship between human leukocyte antigen (HLA), cytokine gene polymorphisms, in Chinese Han population. The polymorphisms of HLA-A, -B, -DRB1, tumor necrosis factor alpha [TNF-α (-308 A/G)], transforming growth beta [TGF-β1 (+869 T/C)], interleukin 10...
Background: Although roles of genetic polymorphisms leptin receptor (LEPR) gene in several cancers have been documented, the association between LEPR and clear cell renal carcinoma (CC-RCC) remains unknown. The aim this study was to explore any relation. Materials Methods: population consisted 77 patients with CC-RCC 161 healthy control subjects. Polymorphism analyses Lys109Arg Gln223Arg were performed by direct DNA sequencing PCR-restriction fragment length polymorphism approaches...
Infection and rejection are common complications faced by lung transplant recipients (LTRs) have become major impediments to long-term survival. Cytokines may play an important role in the development of these complications. In this study, we explored correlation between TNF-α (-308 A/G), TGF-β1 (+869 T/C, +915 G/C), IL-10 (-592 C/A, -819 -1082 G/A), IL-6 (-174 IFN-γ (+874 T/A) gene polymorphisms incidence acute infection. Transplant outcomes were reviewed a retrospective cohort 113 LTRs...
Clear cell renal carcinoma (ccRCC) is one of the most common and lethal types cancer within urinary system. Great efforts have been made to elucidate pathogeny. However, molecular mechanism ccRCC still not well understood. The aim this study identify key genes in carcinogenesis progression ccRCC. mRNA microarray dataset GSE53757 was downloaded from Gene Expression Omnibus database. contains tumor matched paracancerous specimens 72 patients with clinical stage I IV. linear model data (limma)...
The expression and clinical significance of transforming growth factor beta1 (TGF-beta1) matrix metalloproteinase-2 (MMP2) in human renal clear cell carcinoma (RCCC) were investigated. intensity TGF-beta1 MMP2 RCCC kidneys was significantly higher than that normal kidneys. Expression tissues positively correlated with pathological grade stage. There also a significant correlation between Msshese analyses indicate upregulation may occur during the progression RCCC. Thus, be useful molecular...
Amyloid-β (Aβ) protein and its precursor, amyloid-β precursor (β-APP), have traditionally been used in the diagnosis of Alzheimer disease. Their use traumatic brain injury by forensic analysis is becoming more widespread. However, to date, no reliable small animal model exists evaluate these indicators. To address this, we studied primary brain-stem rats assess appearance diffuse axonal sections correlate findings with Aβ relative β-APP mRNA levels. Using an EnVision 2-step...
Traumatic brain injury (TBI) is a common cause of death and disability. Enhancing the midline-crossing contralateral corticospinal tract (CST) to denervated side spinal cord facilitates functional recovery after TBI. Activation gamma isoform PKC (PKCγ) in CST implicates its roles promoting remodeling In this study, we deployed loss gain function strategies N2a cells primary cortical neurons vitro, demonstrated that PKCγ not only important but necessary for neuronal differentiation, neurite...
Expression of the CDH13 gene in chronic myeloid leukaemia (CML) patients at different clinical stages, and its relationship with BCR/ABL fusion gene, is investigated. fuse investigated peripheral blood from 30 healthy adults, 25 primary CML blast crisis using EvaGreen real-time reverse transcriptase polymerase chain reaction (RT-PCR). Results showed that expression was 4.72-fold higher than CML. mRNA lower reduced 64% 75%, respectively. a negative correlation gene. The data indicate decline...
Genes encoding histocompatibility leukocyte antigen (HLA) and proinflammatory cytokines are involved in rejection after organ transplant. The authors explored the association between HLA alleles tumor necrosis factor (TNF)- α-308 G/A promoter region lung transplant recipients of Han nationality from East China. They also evaluated correlation TNF-α-308 onset acute transplant.All who were admitted into our hospital August 2004 July 2011 included. Patients divided 2 groups according to...
We investigated 2 Chinese families with dyschromatosis symmetrica hereditaria (DSH) and to search for mutations in the ADAR1 gene these pedigrees.We performed a mutation analysis of DSH reviewed all published articles regarding reported since 2003 by using PubMed.By direct sequencing, 2-nucleotide AG deletion, 2099-2100delAG, was found family 1, C→T identified at nucleotide 1420 that changed codon 474 from arginine translational termination 2. Two different pathogenic were identified, is,...
T315I mutations of the BCR::ABL1 gene lead to resistance tyrosine kinase inhibitors (TKIs). This study evaluated performance digital droplet polymerase chain reaction (ddPCR) in quantifying and their frequency Philadelphia chromosome (Ph) positive hematological patients. The course disease fusion transcripts (e13a2, e14a2 e1a2) were retrospectively reviewed 21 patients with acute lymphoblastic leukemia (ALL) 85 chronic myeloid (CML). mutation analysis was carried out using ddPCR limit...
Abstract Background TRIzolTM is widely used for RNA and DNA extraction. However, this method laborious time-consuming. The objective of study was to validate a time-effective labor-saving protocol. Methods TRIzol separate the aqueous phase, protein, phenol layer bone marrow samples from 12 patients with hematological diseases. Subsequently, were extracted containing DNA, respectively, using magnetic bead extraction kits. quantity purity examined NanoDrop spectrophotometer. Quantitative...