A5101553825- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Lipoproteins and Cardiovascular Health
- Pericarditis and Cardiac Tamponade
- Infective Endocarditis Diagnosis and Management
- Retinoids in leukemia and cellular processes
- Cardiac Ischemia and Reperfusion
- Nitric Oxide and Endothelin Effects
- Antioxidant Activity and Oxidative Stress
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- COVID-19 and healthcare impacts
- Diabetes Treatment and Management
- Intensive Care Unit Cognitive Disorders
- Vascular anomalies and interventions
- Systemic Lupus Erythematosus Research
- Ginseng Biological Effects and Applications
- Macrophage Migration Inhibitory Factor
- Fungal Biology and Applications
- Ziziphus Jujuba Studies and Applications
Shanghai Chest Hospital
2019-2024
Shanghai Jiao Tong University
2012-2024
Renji Hospital
2008-2017
University of Oxford
2017
Chinese University of Hong Kong
2015
Prince of Wales Hospital
2015
To determine the association between low molecular weight heparin (LMWH) use and mortality in hospitalized COVID-19 patients. We conducted a retrospective study of patients consecutively enrolled from two major academic hospitals exclusively for Wuhan, China, January 26, 2020, to March 2020. The primary outcome was adjusted in-hospital LMWH group compared with non-LMWH using propensity score. Overall, 525 median age 64 years (IQR 19), 49.33% men. Among these, 120 (22.86%) were treated LMWH....
Septic cardiomyopathy is associated with mechanisms such as excessive inflammation, oxidative stress, regulation of calcium homeostasis, endothelial dysfunction, mitochondrial and cardiomyocyte death, there no effective treatment at present. MOTS-c a mitochondria-derived peptide (MDP) encoded by DNA (mtDNA) that protects cells from stresses in an AMPK-dependent manner. In the present study, we aim to explore protective effect on lipopolysaccharide (LPS)-induced septic cardiomyopathy. LPS...
Background and Purpose Atherosclerosis is a chronic inflammatory disease, retinoid X receptor‐α (RXRα) an intriguing anti‐atherosclerosis target. This study investigated whether how RXRα modulator, K‐80003, derived from non‐steroidal anti‐inflammatory drug attenuates atherosclerotic plaque progression destabilization. Experimental Approach Our previously established ApoE −/− mouse model of carotid vulnerable was treated with K‐80003 or vehicle for 4 8 weeks. Samples arteries serum were...
Background Cardiac rupture is a disastrous but uncommon complication of acute ST-elevation myocardial infarction (STEMI). The incidence, risk factors and in-hospital outcomes related to cardiac in the current era are unknown. Methods This study consecutively collected all STEMI patients admitted single tertiary center China from January 2004 December 2015. Characteristics each were analyzed. Results Among 4190 patients, 75 (1.8%) had rupture, including 33 at ventricular septum 42 left...
Background Coronary artery calcium (CAC) is a modifiable contributor of in-stent restenosis (ISR), but quantitative analyses using noninvasive approach are limited. We aimed to investigate the associations between CAC score derived from ECG-gated coronary computed tomography angiography (CCTA) or non-gated non-contrast chest (NCCT) and ISR. Methods included 368 lesions in 194 patients with drug-eluting stent implantations final analyses. was quantified Agatston score. Primary endpoint ISR,...
虽然直接经皮冠状动脉介入治疗（PCI）仍是急性ST段抬高型心肌梗死（STEMI）的首选再灌注策略，然而，每年仍有大量的新发STEMI患者无法于最佳时间窗内接受直接PCI治疗。近年来，学界开始越来越重视先溶栓再进行PCI治疗的“药物介入”策略，以及该策略与直接PCI在疗效和安全性方面的比较。近来的一些临床研究证据逐渐表明，药物介入策略对STEMI患者安全有效，特别是当确诊后无法于120 min内进行直接PCI治疗时，选择药物介入策略不亚于直接PCI。该文复习了近来这两大策略的对比研究，对STEMI患者的再灌注策略选择提出了新的建议。.
Transcatheter edge-to-edge repair (TEER) of the mitral valve has emerged as a standard treatment for patients with severe degenerative regurgitation at high or prohibitive surgical risk. The devices approved by Food and Drug Administration including MitraClip (Abbott Vascular, California, USA) PASCAL (Edwards Lifesciences, cost over $33,000 in western countries.[1] This pricing presents significant economic burden especially developing countries, where TEER are typically not covered health...
Background: Acquisition and maintenance of vascular smooth muscle cell (VSMC) fate are important for development homeostasis; however, little is known about the key determinant VSMC homeostasis. Methods: Lkb1 flox/flox ; Tagln- Cre, flox /flox Myh11-Cre/ERT2 , lineage tracing ROSA mT/mG mice were generated to study impact on function in vivo . Single aortic cells isolated from wild-type analyzed by single-cell RNA sequencing (sc-RNA seq). The dynamic changes morphology investigated using...
<h3>Clinical introduction</h3> A 59-year-old woman who underwent mitral valve replacement and tricuspid annuloplasty with the De Vega technique without a rigid ring 16 years ago for rheumatic stenosis was referred to our hospital aggressive dyspnoea oedema of lower extremities refractory diuretics. ECG showed atrial fibrillation. Transthoracic echocardiography reveal ed severe regurgitation, preserved left right ventricular systolic function, slightly elevated pulmonary artery...
CLINICAL INTRODUCTION: A 36-year-old man was referred for evaluation of an abnormal left ventricular (LV) structure found incidentally on transthoracic echocardiography (TTE) (figure 1). He had no symptoms except mild palpitations. There significant medical history. Physical examination unremarkable. ECG showed regular sinus rhythm with ST changes in lead II, III, avF and V6 (see online supplementary file Cardiac magnetic resonance (CMR) 1C) performed. Treadmill exercise test did not...
Objectives: The RAR-related orphan receptors (RORs) are members of the nuclear receptor superfamily that play a pivotal role in many physiological processes, including regulation circadian rhythm, development, metabolism and immune function. Three different but highly homologous ROR isoforms, ROR-α, -β, -γ, have been discovered separately. However, functional roles RORs heart never investigated. We investigate pathophysiology acute myocardial ischemia/ reperfusion (MI/R) injury. Methods...