A5100427796- Healthcare and Venom Research
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- Acupuncture Treatment Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Spine and Intervertebral Disc Pathology
- Coronary Interventions and Diagnostics
- Airway Management and Intubation Techniques
- Medical Research and Treatments
- Trauma Management and Diagnosis
- Myofascial pain diagnosis and treatment
- Metabolomics and Mass Spectrometry Studies
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrhythmias and Treatments
- Diet and metabolism studies
- Atrial Fibrillation Management and Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Musculoskeletal pain and rehabilitation
- Anesthesia and Sedative Agents
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Lipoproteins and Cardiovascular Health
Shanghai Jiao Tong University
2016-2025
Shanghai Ninth People's Hospital
2022-2025
Hubei University of Medicine
2024-2025
Taihe Hospital
2024-2025
Shanghai Sixth People's Hospital
2014-2024
Tongren Hospital
2023-2024
Daping Hospital
2022
Army Medical University
2022
First People's Hospital of Chongqing
2022
Shanghai University of Engineering Science
2019-2020
Although gemcitabine has been considered as the first-line drug for advanced pancreatic cancer (PC), development of resistance to severely limits effectiveness this chemotherapy, and underlying mechanism remains unclear. Various factors, such ATP binding cassette (ABC) transporters, microRNAs their downstream signaling pathways are included in chemoresistance gemcitabine. This study investigated potential mechanisms ABC transporters related PC both vivo vitro.Immunohistochemistry Western...
Objective To explore the risk factors associated with postoperative delirium (PD) in elderly patients following total hip arthroplasty (THA) for fracture. Methods This prospective study enrolled (≥ 65 years) fractures who underwent THA under general anaesthesia, and had a complete set of observations. Detailed medical history perioperative characteristics were recorded. During period, assessed twice daily PD using Confusion Assessment Method. Results A 572 eligible inclusion study. Of these,...
Microglial polarization toward pro-inflammatory M1 phenotype are major contributors to the development of perioperative neurocognitive disorders (PNDs). Metabolic reprogramming plays an important role in regulating microglial polarization. We therefore hypothesized that surgical trauma can activate by metabolic induce hippocampal neuroinflammation and subsequent postoperative cognitive impairment.We used aged mice establish a model PNDs, investigated whether induced reprograming hippocampus...
Abstract Background Dyslipidemia is one of independent risk factors for coronary atherosclerotic heart disease (CAHD). We determined whether the LDL/HDL ratio better than LDL-C or HDL-C alone in predicting severity CAHD. Methods performed a retrospective study 1351 patients with myocardial ischemia who underwent angiography between January 2018 and December 2019 Shanghai Ninth People’s Hospital. Spearman correlation analysis, logistic regression model, Cox proportional hazards model...
Abstract Background: Postoperative cognitive dysfunction is a clinical entity that associated with poor outcome. We determined the effectiveness of amantadine in reducing surgery-induced impairment and role glial cell line-derived neurotrophic factor (GDNF) this effect. Methods: Four-month old male Fischer 344 rats were subjected to right carotid exposure under intravenous anesthesia. Some received intraperitoneal injection 25 mg/kg/day for 3 days first dose at 15 min before surgery or...
Plaque vulnerability and rupture rather than plaque size are the major cause of clinical events in patients with intermediate coronary lesions. Therefore, present study was aimed to explore potential markers associated acute syndrome (ACS) A total 82 ACS presenting only lesions (40-70% stenosis demonstrated by quantitative angiography) no severe other main arteries [median age 63 years, 53 male 29 female] were enrolled. morphology assessed optical coherence tomography (OCT). Hematological...
The accurate assessment of platelet activity is crucial in clinical practice and scientific research owing to the pivotal role platelets progression cardiovascular conditions, such as arterial thrombotic diseases. However, conventional methods are currently limited by their requirement substantial blood samples inadequate high-throughput capabilities, therapeutic resistance induced antiplatelet agents impedes treatment efficacy. In this study, we developed a microdroplet-based function...
Introduction The purpose of this study is to evaluate the safety and efficacy two different antithrombotic strategies, dual antiplatelet therapy (DAPT, aspirin ticagrelor) direct oral anticoagulant (DOAC, rivaroxaban), after left atrial appendage closure (LAAC) using LACbes occluder. Methods analysis This a prospective, randomised, controlled multicentre clinical trial that will compare anticoagulation LAAC with It planned enrol 296 subjects non-valvular fibrillation (NVAF) who complete...
Cancer rehabilitation is the crucial process by which cancer patients regain their physical abilities and enhance quality of life through diverse methods following treatment. As cure rate continues to rise, need for postoperative becoming increasingly evident. This particularly enhancing patient survival rates minimizing chances recurrence. Exercise intervention has become popular widely used as a proactive therapy in recent years. article examines influence exercise on recovery after...
Hypotheses on the development of postoperative delirium (PD) include "neuroinflammatory," "neuronal aging," "oxidative stress," "neurotransmitter deficiency," and "neuroendocrine." Here, we employed metabolomics to determine serum metabolites in baseline associated with an increased risk PD. Two hundred nine elderly hip-fracture patients who had undergone hemiarthroplasty completed our assessments were selected. Fasting venous blood was collected at 7:00 morning surgery a sample bank created...
Sepsis-induced acute kidney injury (AKI) can increase the mortality of critically ill patients and incidence chronic disease in survivors. The main goal was to investigate possible link between metabolic changes sepsis-induced AKI development. experimental animal model established by intraperitoneal injection lipopolysaccharide rats. Non-targeted screening renal cortex control groups carried out based on gas chromatography coupled with quadrupole time-of-flight mass spectrometry (GC-TOFMS)...
Cucurbitacin E (CuE), a potent member of triterpenoid family isolated from plants, has been confirmed as an antitumour agent by inhibiting proliferation, migration and metastasis in diverse cancer. However, the effects mechanisms CuE on osteosarcoma (OS) have not well understood. The present study aimed to test whether could inhibit growth invasion OS cells reveal its underlying molecular mechanism. After various concentrations treatment, anti-proliferative effect was assessed using cell...
Pathophysiological disorders after surgery might be related to postoperative delirium (POD). This study was designed elucidate the pathogenesis of POD in elderly oral cancer patients by determining perioperative kinetics inflammatory cytokines, cortisol, and amyloid β1-40 (Aβ1-40).A total 257 who underwent tumor resection were selected. Venous blood collected prior (T0), at end (T1), 12 hours (T2). During first three days, examined using confusion assessment method twice a day (8 am 8 pm)....
post-operative delirium (POD) is a common complication in older patients, though possible link between metabolic changes and POD development has yet to be investigated.older patients with hip fracture who underwent hemi-arthroplasty were recruited, delirious states assessed for 3 days after surgery using the confusion assessment method-Chinese revision. Simultaneously, fasting blood samples collected on morning of first day. Ultimately, 244 met inclusion exclusion criteria assessed. Blood...
Men with congestive heart failure (CHF) have relatively low testosterone levels. Several studies demonstrated that treatment increases cardiac output and reduces peripheral vascular resistance. However, the effects of on function, cardiomyocyte apoptosis ventricular remodeling not been fully elucidated. This study was conducted to investigate in male rats post-myocardial infarction. A total 86 were randomly assigned undergo ligation coronary artery (n=70) or pseudosurgery (n=16). After 6...
Background . Postoperative cognitive dysfunction (POCD) is a common complication after abdominal surgery. Several studies have reported that POCD related to neuroinflammation caused by Omega‐3 polyunsaturated fatty acids (PUFAs) can effectively inhibit the systematic inflammatory response. So, we use fish oil study effect of on inflammation, immunity, and behavior splenectomy in rats. Methods 60 SD (Sprague‐Dawley) rats were randomly divided into control group (group C, n = 20), surgery S,...
This study was performed to investigate the effect of early pressure dressing on prevention postoperative subdural effusion secondary decompressive craniectomy (DC) in patients with severe traumatic brain injury (STBI). Patients STBI who had undergone DC for refractory increased intracranial between January 2008 and December 2011 (n = 169) were randomly divided into 82) control 87) groups. Early an elastic bandage or general wrapping (control treatment) applied 7 10 days after DC. Patients’...
Continuous nerve block with ropivacaine is commonly performed after repair surgery for traumatic peripheral injuries. After injury, tetrodotoxin-resistant voltage-gated sodium channel Nav1.8 upregulated and contributes to macrophage inflammation. This study investigated whether promotes regeneration through Nav1.8-mediated signaling.A sciatic transection-repair (SNT) model was established in adult Sprague-Dawley rats of both sexes. The received 0.2% or 10 μM Nav1.8-selective inhibitor...