A5103060738- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Phagocytosis and Immune Regulation
- Radiomics and Machine Learning in Medical Imaging
- Molecular Biology Techniques and Applications
- Extracellular vesicles in disease
- Cancer, Stress, Anesthesia, and Immune Response
- Language, Metaphor, and Cognition
- Gastric Cancer Management and Outcomes
- Drug Transport and Resistance Mechanisms
- Cancer Cells and Metastasis
- Gene expression and cancer classification
- Nanoplatforms for cancer theranostics
- Computational Drug Discovery Methods
- Chinese history and philosophy
Chongqing University
2024
First People's Hospital of Chongqing
2022-2024
Zhujiang Hospital
2019-2023
Southern Medical University
2019-2023
Although gemcitabine has been considered as the first-line drug for advanced pancreatic cancer (PC), development of resistance to severely limits effectiveness this chemotherapy, and underlying mechanism remains unclear. Various factors, such ATP binding cassette (ABC) transporters, microRNAs their downstream signaling pathways are included in chemoresistance gemcitabine. This study investigated potential mechanisms ABC transporters related PC both vivo vitro.Immunohistochemistry Western...
Abstract Numerous long noncoding RNAs (lncRNAs) are aberrantly expressed in pancreatic cancer (PC); however, their functions and mechanisms progression largely unknown. In this study, we identified a novel PC-associated lncRNA, RUNX1-IT1, that was significantly upregulated PC patient samples from multiple centers associated with poor prognosis. vitro vivo, alterations RUNX1-IT1 expression markedly affected proliferation, migration invasion. contributed to the of by interacting adjacent gene...
MicroRNAs (miRNAs), as an indispensable type of non-coding RNA (ncRNA), participate in diverse biological processes. However, the specific regulatory mechanism certain miRNAs pancreatic ductal adenocarcinoma (PDAC) remains unclear.
To identify key microRNAs (miRNAs) and their target mRNAs related to gemcitabine-resistant pancreatic cancer (PC) investigate the association between gemcitabine-resistant-related miRNAs immune infiltration.Expression profiles of were obtained from Gene Expression Omnibus (GEO) database. The differentially expressed (referred as "DEmiRNAs" "DEmRNAs", respectively) distinguished PC cells its parental cells. DEmRNAs targeted by DEmiRNAs retrieved using miRDB, microT, Targetscan. Furthermore,...
Pancreatic ductal adenocarcinoma (PDAC) is associated with several genetic syndromes. However, the molecular mechanism underlying PDAC progression still unknown. In this study, we showed that Laminin Subunit Beta 3 (LAMB3) was aberrantly overexpressed in and closely overall survival rate of patients PDAC. Functional studies demonstrated LAMB3 played important roles cell proliferation, cycle, invasion capacity. Using bioinformatics analysis, determined miR-24-3p an upstream miRNA LAMB3,...
Pancreatic cancer (PC) is a severe disease with the highest mortality rate among various cancers. It urgent to find an effective and accurate way predict survival of PC patients. Gene set variation analysis (GSVA) was used establish validate miRNA set-based pathway prognostic signature for (miPPSPC) mRNA (mPPSPC) in independent datasets. An optimized miPPSPC constructed by combining clinical parameters. The miPPSPC, mPPSPC were established validated patients showed excellent predictive...
Pancreatic ductal adenocarcinoma (PDAC) is severely affecting the health and lives of patients. Clarifying composition regulatory factors tumor immune microenvironment (TIME) helpful for treatment PDAC. We analyzed unique TIMEs gene expression patterns between PDAC adjacent normal tissue (ANT) using Gene Expression Omnibus (GEO) to find new immunotherapy targets. The Cancer Genome Atlas (TCGA) datasets were used elucidate possible mechanism which tumor-associated macrophages (TAMs) changed...
Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) is severely affecting the health and lives of patients. Clarifying composition regulatory factors tumor immune microenvironment (TIME) helpful for treatment PDAC.Methods: We analyzed unique TIMEs gene expression patterns between PDAC adjacent normal tissue (ANT) using Gene Expression Omnibus (GEO) to find new immunotherapy targets. The Cancer Genome Atlas (TCGA) datasets were used elucidate possible mechanism which...
Perineural invasion (PNI) is associated with local recurrence, distant metastasis, and a poor prognosis in pancreatic cancer. However, rare attempt was made to identified the PNI intraoperative. To facilitate precise R0 excision of tumor, we planned develop fluorescent probe for intraoperative imaging using GAP-43 as target indocyanine green (ICG) carrier.The created by binding peptide antibody ICG. Its targeting tested vitro vivo co-culture model PC12 tumor cells create an neural mouse...