A5102819422- Cancer-related molecular mechanisms research
- Climate Change and Health Impacts
- Circular RNAs in diseases
- Medicinal Plants and Bioactive Compounds
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- Inflammatory mediators and NSAID effects
- Acute Myocardial Infarction Research
- Global Health Care Issues
- Cardiac Imaging and Diagnostics
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Advanced Glycation End Products research
- Redox biology and oxidative stress
- Biomarkers in Disease Mechanisms
- Cardiac electrophysiology and arrhythmias
- Air Quality and Health Impacts
- Cardiovascular Function and Risk Factors
- Plant-based Medicinal Research
- Sleep and related disorders
- Traditional Chinese Medicine Studies
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
First Affiliated Hospital of Xinxiang Medical University
2017-2025
Xinxiang Medical University
2007-2025
Changzhi Medical College
2021-2025
Beijing Anzhen Hospital
2024
Capital Medical University
2024
Guangzhou Medical University
2022
Beijing University of Posts and Telecommunications
2009-2020
Tongji Hospital
2007-2008
Huazhong University of Science and Technology
2007-2008
Observational studies have suggested strong associations between sleep duration and many cardiovascular diseases (CVDs), but causal inferences not been confirmed. We aimed to determine the genetically predicted 12 CVDs using both linear nonlinear Mendelian randomization (MR) designs.Genetic variants associated with continuous, short (≤6 h) long (≥9 durations were used examine among 404 044 UK Biobank participants of White British ancestry. Linear MR analyses showed that was negatively...
Abstract Context Insomnia is associated with insulin resistance (IR) in observational studies; however, whether insomnia causally IR remains unestablished. Objective This study aims to estimate the causal associations of and its related traits. Methods In primary analyses, multivariable regression (MVR) 1-sample Mendelian randomization (1SMR) analyses were performed (triglyceride-glucose index triglyceride high-density lipoprotein cholesterol [TG/HDL-C] ratio) traits (glucose level, TG,...
Coronary heart disease (CHD) is a major cause of morbidity and mortality an important public health problem globally, but the mechanism CHD still complex unclear. The purpose current study was to explore underlying using high‑throughput technology. participants were patients with coronary angiography (CAG)‑proven severity artery stenosis. Patients divided into control test group based on specific inclusion criteria, data collected regarding results routine inspection Gensini score (GS). We...
This study sought to investigate whether reactive oxygen species (ROS)-generating reduced nicotinamide adenine dinucleotide phosphate oxidase 2 (Nox2) contributes calcific aortic valve disease (CAVD) or celastrol, a natural Nox2 inhibitor, may provide potential therapeutic target for CAVD. CAVD is an active and cellular-driven fibrocalcific process characterized by differentiation of valvular interstitial cells (AVICs) toward osteogenic-like phenotype. ROS levels increase in calcified...
Background: Resolvin D2 (RvD2), which exhibits anti-inflammatory properties, is neuroprotective. This study aimed to ascertain the potential of serum RvD2 level as a prognostic predictor moderate-to-severe traumatic brain injury (msTBI). Methods: In this prospective cohort study, levels were measured in 136 patients with msTBI and 100 healthy controls. The severity scoring systems encompassed Rotterdam computed tomography classification Glasgow Coma Scale (GCS). Post-trauma six-month outcome...
The effect of the diurnal temperature range (DTR) on human health in diverse geographic areas and potential confounding factors are not fully understood. Additionally, while a robust association has been reported between cardiomyopathy (CM), evidence impact DTR is relatively limited. Here, we determined whether an exists CM hospitalisations vulnerable populations. admission data (2016-2021) were collected from seven tertiary hospitals Henan.We used GAM combined with distributed lag...
Purpose: Ginkgolide B (GB) is a terpene lactone component found in Ginkgo biloba , which has protective role on ischemia reperfusion (I/R) injury. This study was aimed at exploring the mechanism of GB myocardial I/R. Patients and methods: Myocardial I/R model established Sprague Dawley rats. The levels cardiac troponin I, T, lactic dehydrogenase, myoglobin were determined by 200FR NEO automatic biochemical analyzer. Histological examination performed through HE terminal deoxynucleotidyl...
Background . With the development of biological technology, biomarkers for prevention and diagnosis acute coronary syndrome (ACS) have become increasingly evident. However, study novel circular RNAs (circRNAs) in ACS is still progress. This aimed to investigate whether regulation circRNA‐miRNA networks involved pathogenesis. Methods We used microarray analysis detect significantly expressed circRNAs miRNAs peripheral blood patients control group (CG) groups, including an unstable angina...