A5022024517- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Mesenchymal stem cell research
- Atherosclerosis and Cardiovascular Diseases
- Coronary Artery Anomalies
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Tissue Engineering and Regenerative Medicine
- Elasticity and Material Modeling
- NF-κB Signaling Pathways
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Advanced Glycation End Products research
- Protease and Inhibitor Mechanisms
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pulmonary Hypertension Research and Treatments
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Advanced MRI Techniques and Applications
Zhongda Hospital Southeast University
2015-2024
Southeast University
2008-2015
Jiangsu Province Hospital
2002
Nanjing Medical University
1994-2002
Objective: To explore the role of neutrophil-to-lymphocyte ratio (NLR) in predicting short-term prognosis NSTEMI and STEMI. Methods: This study was a single-center, retrospective observational study. 2618 patients including 1289 NSTMI 1329 STEMI were enrolled from June 2013 to February 2018 Zhongda Hospital, Southeast University. The demographic information, clinical characteristics, medical history, laboratory examination, treatment, outcome individuals at admission during hospitalization...
Background Coronary tortuosity (CT) is a common coronary angiography finding. The exact pathogenesis, clinical implication and long-term prognosis of CT are not fully understood. purpose this study to investigate the characteristics in patients with suspected artery disease(CAD) Chinese population. Methods A total 1010 consecutive underwent complaints chest pain or related symptoms were included present (544 male, mean age: 64±11 years). was defined by finding ≥3 bends (defined as ≥45°...
Background and aims: In Chinese patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS), it is essential to evaluate the net clinical benefit (NCB) of fondaparinux compared low molecular weight heparin (LMWH) in NSTE-ACS varying bleeding ischemic risks. Methods: This multicenter, prospective, open-label, real-world study enrolled 8066 adult undergoing non-emergency percutaneous intervention (PCI) at 88 hospitals from July 2019 2021. Patients received (2.5 mg/d) or LMWH (1...
Background Tinnitus, a common auditory disorder, significantly impacts patient quality of life and lacks universally effective treatments. The integration advanced imaging technology like ultrasound in therapeutic interventions offers new possibilities healthcare. Objective This study evaluated the efficacy ultrasound-guided stellate ganglion block as an innovative approach to managing tinnitus. Methods Eighty patients with tinnitus were randomly assigned either control group receiving...
Atherosclerosis is the leading cause of cardiovascular disease worldwide, including in China. Primary prevention, through lipid-lowering, could avert development atherosclerosis. Carotid intima-media thickness (CIMT) a well-validated measure atherosclerosis used intervention studies as primary outcome and alternative end point for events.This randomized, double-blind, placebo-controlled, multicenter, parallel-group study assessed effects rosuvastatin 20 mg/d compared with placebo on...
Acute myocardial infarction (AMI) is a leading cause of death and disability worldwide. Early diagnosis AMI interventional treatment can significantly reduce damage. However, owing to limitations in sensitivity specificity, existing markers are not efficient for early identification AMI. Transcriptome-wide association studies (TWASs) have shown excellent performance identifying significant gene-trait associations several cardiovascular diseases (CVDs). Furthermore, ferroptosis major driver...
The aim of this study was to evaluate the roles fibroblast growth factor 21 (FGF21) in heart failure patients with reduced ejection fraction and its association Heart Failure Ejection Fraction (HFrEF). level FGF21 measured by enzyme-linked immunosorbent assay (ELISA) 199 subjects enrolled study, including 128 HFrEF 71 control subjects. mean follow-up time 13.36 months. left ventricular end-diastolic diameter (LVEDD) (LVEF) percentage were evaluated 2D echocardiography. Serum brain...
This study aimed to evaluate the potential associations of intermediate monocytes (CD14(++)CD16(+)) with myocardial remodelling in ST segment elevation infarction (STEMI) patients diabetes.A total 67 STEMI diabetes were enrolled. The control group consisted 65 without diabetes. All received emergency medical services for reperfusion therapy less than 12 hours after onset AMI. Blinded patient clinical characteristics, monocyte subset analysis was performed using flow cytometry immediately...
Cardiovascular magnetic resonance based tissue tracking (CMR-TT) was reported to provide detailed insight into left ventricular (LV) contractile function and deformation with both of two- three-dimensional (2/3D) algorithms. This study designed investigate the feasibility reproducibility these two techniques for measuring LV global segmental strain, establish gender- age-related reference values multi-dimensional peak strains among large healthy population.We retrospectively recruited 150...
Background The triglycerides-glucose index (TyG) and the triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) are simple indicators for assessing insulin resistance in epidemiological studies. We aimed clarify relationship between of prognosis non-diabetic acute myocardial infarction (AMI) patients. Methods A total 1,648 AMI patients without diabetes were enrolled from Department Cardiology, Zhongda Hospital, 2012.03 2018.12. medical history, laboratory imaging data collected...
Atherosclerotic plaque progression and rupture are believed to be associated with mechanical stress conditions. In this paper, patient-specific in vivo intravascular ultrasound (IVUS) coronary image data were used construct computational models fluid-structure interaction (FSI) cyclic bending investigate correlations between wall thickness both flow shear conditions.IVUS acquired from 10 patients after voluntary informed consent. The X-ray angiogram was obtained prior the pullback of IVUS...
Heart disease is one of the most important causes death in developed countries. Nε-carboxymethyllysine (CML) a major advanced glycation end product formed by combined reactions non-enzymatic and oxidation (glycoxidation), it represents general marker oxidative stress. CML has been suggested to be involved pathogenesis heart disease. Plasma elevated aging, atherosclerosis and/or diabetes. In this study, we measured cardiac levels elucidate its role Cardiac tissues were collected from 105...
Accurate cap thickness quantification is of fundamental importance for vulnerable plaque detection in cardiovascular research. A segmentation method intracoronary optical coherence tomography (OCT) image based on least squares support vector machine (LS-SVM) was performed to characterize component borders and quantify fibrous thickness. Manual OCT images were by experts combination virtual-histology intravascular ultrasound (VH-IVUS) used as gold standard. The methods LS-SVM provided...
The role of tripartite motif (TRIM) 38, a ubiquitin E3 ligase regulating various pathophysiological processes, in cardiac fibrosis remains unclear. Here, model angiotensin II and myocardial infarction (MI)-induced was established to explore its underlying mechanisms. Cardiac the mouse MI mitigated by TRIM38 overexpression, but aggravated depletion. Consistently, vitro overexpression or knockdown ameliorated proliferation secretion fibroblasts (CFs) exposed fibrotic stimulation, respectively....
In patients undergoing percutaneous coronary intervention after acute myocardial infarction, hyperglycaemia on admission is associated with an increased risk of contrast-induced nephropathy (CIN). However, the effects and elevated glycosylated haemoglobin (HbA1c) CIN have remained to be fully elucidated. Therefore, a prospective cohort study was performed, comprising 258 who underwent angiography between May 2017 November at Zhongda Hospital affiliated Southeast University (Nanjing, China)....
Acute myocardial infarction (AMI) remains one of the leading causes mortality worldwide; however, endothelial progenitor cell (EPC) transplantation has been proposed as a promising treatment strategy for EPC. High levels tumor necrosis factor-related weak inducer apoptosis (TWEAK) have reported in AMI, although its effect on EPCs not reported. In present study, immunofluorescence and flow cytometry were performed to assess TWEAK isolated mouse EPCs. Echocardiography was used evaluate cardiac...