In February 2020, a novel coronavirus (SARS-COV2) broke out in Wuhan city of China. The Chinese government decisively imposed nationwide confinement. This study comprised structured, online questionnaire, based on 40 items inquiring about socio-demographic information and anthropometric data (reporting weight height), as well changes food intake, physical activity, sleep during the COVID-19 outbreak. Questionnaires were distributed to residents Jiangsu other provinces from 29 March 5 April....

Bone marrow mesenchymal cells (MSCs) have attracted increasing research interest due to their possible use as support for nerve tissue-engineering approaches. We developed a novel design of tissue-engineered grafts consisting chitosan/poly(lactic-co-glycolic acid) (PLGA)-based neural scaffold included with autologous MSCs. The graft was used an alternative autografts bridging 50-mm-long gaps in dog sciatic nerve, and the repair outcome at 6 months after grafting evaluated by combination...

Lipid metabolism is closely related to the occurrence and development of breast cancer. Our purpose was establish a novel model based on lipid metabolism-related long noncoding RNAs (lncRNAs) evaluate potential clinical value in predicting prognosis for patients suffering from cancer.RNA data information cancer were obtained genome atlas (TCGA) database. lncRNAs identified via criteria correlation coefficient |R2 | > 0.4 p < 0.001, prognostic through Cox regression analysis. The training set...

Objective: This study aimed to determine whether changes in sleep duration are associated with a higher risk of mild cognitive impairment (MCI) older adults.Results: By the 3-year follow-up, 592 participants developed MCI.Compared individuals who had an unchanged duration, odds ratio (95% confidence interval) for MCI was 1.44 (1.08-1.91)for those whose increased by ≥2 h after multivariate adjustments.Moreover, changing from long moderate, but not short, negatively incidence (odds ratio:...

Aims：S-propargyl-cysteine (SPRC) is an endogenous hydrogen sulfide (H2S) donor obtained by modifying the structure of S-allyl cysteine in garlic. This study aims to investigate effect SPRC on mitigating cardiac aging and involvement JMJD3, a histone demethylase, which represents primary risk factor major related diseases, this process, elucidating preliminary mechanism through regulation JMJD3. Results：In vitro, mitigated elevated levels reactive oxygen species (ROS), senescence-associated...

To investigate the role of vascular endothelial growth factor-A (VEGF-A) isoforms in neovascular age-related macular degeneration.Choroidal membranes (CNV) were excised 24 patients, 8 them underwent previous photodynamic therapy. All procedures performed before anti-VEGF therapies implemented Germany. Normal human donor eyes served as controls. Messenger RNA expression total VEGF-A and was measured.Vascular factor-A121 is most abundant isoform CNV control tissues. In controls, VEGF-A121...

Abstract We aimed to compare child body mass index (BMI) in prediction of hypertension early adulthood with 4 other adiposity indices (waist circumference [WC], waist circumference‐to‐height ratio [WHtR], waist‐to‐hip [WHR], and triceps skinfold [TSF]). The cohort from the China Health Nutrition Survey 1993‐2011 consisted 1444 adults aged 18‐36 years who were examined childhood adulthood. Child adult blood pressure (BP) transformed into age‐, sex‐, survey year‐specific Z ‐scores. Adult was...

Numerous studies have demonstrated the ability of body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height (WHtR) to predict risk type 2 diabetes mellitus (T2DM) cardiovascular diseases (CVD). This study aimed evaluate predictive value these anthropometries for metabolic abnormalities related in Chinese adults.A cross-sectional was conducted 477 men 3 107 women at 20-79 years old who were randomly selected from Pudong New Area Shanghai, China, through a...

Previous studies have found that LMX1B rs10733682 polymorphism is associated with Body Mass Index (BMI) in European and American Indian adults. In this study, the association of obesity-related indicators, its interaction macronutrients dietary patterns (DPs) were explored Chinese children (n = 798). The was genotyped by improved Multiple Ligase Detection Reaction (iMLDR). Four DPs identified factor analysis. AA genotype had a higher incidence overweight/obesity than GG+GA genotypes (P...

Background: The potential effects of excess weight status in childhood on later adult cardiometabolic risk factors have been undetermined a Chinese population. Additionally, the mitigation these if returns to normalcy has unresolved. Accordingly, we aimed assess association and its long-term change with factors. Methods: A cohort study from China Health Nutrition Survey 1991-2009 consisted 541 participants who were measured (≥6 <18 years) underwent laboratory assessment adulthood (≥18...

A genome-wide association study (GWAS) in the Han Chinese population had found that single nucleotide polymorphism (SNP) on CMTM7 gene rs347134 was significantly associated with Body Mass Index (BMI). In present study, of SNP obesity and its interaction dietary patterns (DPs) were explored children. This cross-sectional group included 1292 children, whom obesity-related indicators evaluated, genotyped by improved Multiple Ligase Detection Reaction (iMLDR), DPs identified principal component...

The aim of this study was to observe the effect Rehmannia glutinosa oligosaccharide (RGO) on differentiation bone marrow mesenchymal stem cells (MSCs) into cardiomyocyte-like . Rat MSCs were isolated, treated, and grouped as follows: RGO treatment group, 5-azacytidine (5-aza) + 5-aza control group. Following a four-week induction period, cardiac troponin I (cTnI) levels in quantified by chemiluminescence, myocardial enzymes creatine kinase (CK) isoenzyme-MB (CK-MB) measured using dry...

Objectives: Our objective was to analyze changes in lifestyle patterns of Chinese college students at home during the COVID-19 outbreak. Methods: According a structured online questionnaire covering socio- demographic information, anthropometric data, and food intake, physical activity, sleep outbreak, relationships between above data before outbreak were analyzed. Results: Among 781 participants, 38.5% had significantly increased their total intake 29.1% decreased activity. Overall, 44%...

Objective: Vitamin D is thought to be deficient in patients with bipolar disorder. The purpose of this study use latent profile analysis identify the patterns vitamin levels episodes depression, and examine relationship among these profiles demographic clinical characteristics.

Previous studies have found that TLR4 rs1928295 polymorphism is associated with Body Mass Index in European and American Indian adults. This study evaluates the relationship between this locus polymorphism, obesity-related parameters dietary patterns Chinese Han Children. A total of 798 children aged 7-12 years were included cross-sectional study. An improved Multiple Ligase Detection Reaction was used for genotyping. Dietary identified by principal component factor analysis. The...

Objective: To investigate the current bedtime routine among Chinese children less than 3 years of age and explore its dose-dependent association with sleep duration quality. Method: Healthy full-term born aged 0-35 months were selected by stratified cluster random sampling method from 8 provinces in China following "Hospital Province-City-County" technical route during 2012-2013.Brief Infant Sleep Questionnaire(BISQ) was used to assess conditions these children.Children's personal family...

Abstract Purpose: This study focused on different exercise motivations, especially mood regulation and their relation to the possible influencing factors of adults in China.Methods: 5242 participants aged 20-69 years from 2016 2018 were recruited this finish questionnaire Guangdong National Physique Monitoring organized by Guangzhou Institute Sports Science. Multiple statistical analyses methods used each motivation its sociodemographic characteristics (gender, age, education job),...

Abstract Objective: To explore the relevant factors of perimenopausal symptoms. Method: Community female subjects conforming to criteria were recruited through advertising. Modified Kupperman Index(KI) was used for evaluation symptoms, Zung Self-Rating Depression Scale (SDS)for depressive symptoms and Anxiety (SAS)for anxiety Eysenck Personality Questionnaire(EPQ) is evaluate individual mental characteristics subjects,including Extraversion(E), Neuroticism (N),Psychoticism(P),and Lie(L)....