A5026646519- Cardiac Valve Diseases and Treatments
- Cardiac Ischemia and Reperfusion
- Infective Endocarditis Diagnosis and Management
- Cardiac Fibrosis and Remodeling
- Atrial Fibrillation Management and Outcomes
- Cardiac and Coronary Surgery Techniques
- Mechanical Circulatory Support Devices
- Pulmonary Hypertension Research and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- MicroRNA in disease regulation
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
- Cardiac Arrest and Resuscitation
- Circular RNAs in diseases
- Signaling Pathways in Disease
- Heart Failure Treatment and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Adipokines, Inflammation, and Metabolic Diseases
- Peptidase Inhibition and Analysis
- Coronary Interventions and Diagnostics
- Acute Kidney Injury Research
- Aortic Disease and Treatment Approaches
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Wangjing Hospital of China Academy of Chinese Medical Sciences
2023-2025
Wuhan University
2023-2024
Renmin Hospital of Wuhan University
2023-2024
Beihang University
2023-2024
Society of Thoracic Surgeons
2022
National Health and Family Planning Commission
2022
University of California, Davis
2022
Circular RNAs are a subclass of non-coding detected within mammalian cells. This study was designed to test the roles circular RNA circ-Foxo3 in senescence using vitro and vivo approaches.Using approaches molecular cellular biology, we show that generated from member forkhead family transcription factors, Foxo3, namely circ-Foxo3, highly expressed heart samples aged patients mice, which correlated with markers senescence. Doxorubicin-induced cardiomyopathy aggravated by ectopic expression...
As central nodes in cardiomyocyte signaling, nuclear AKT appears to play a cardio-protective role cardiovascular disease. Here we describe circular RNA, circ-Amotl1 that is highly expressed neonatal human cardiac tissue, and potentiates AKT-enhanced survival. We hypothesize binds PDK1 AKT1, leading AKT1 phosphorylation translocation. In primary cardiomyocytes, epithelial cells, endothelial found forced expression increased the fraction of pAKT. further detected pAKT circ-Amotl1-treated...
Abstract Background The triglyceride-glucose (TyG) index and its combination with obesity indicators can predict cardiovascular diseases (CVD). However, there is limited research on the relationship between changes in triglyceride glucose-waist height ratio (TyG-WHtR) CVD. Our study aims to investigate change TyG-WHtR risk of Methods Participants were from China Health Retirement Longitudinal Study (CHARLS). CVD was defined as self-reporting heart disease stroke. divided into three groups...
Objective There is some evidence for an association between gut microbiota and nonalcoholic fatty liver disease (NAFLD), alcoholic (ALD), viral hepatitis, but no studies have explored their causal relationship. Methods Instrumental variables of the (N = 13266) microbiota-derived metabolites 7824) were acquired, a Mendelian randomization study was performed to explore influence on NAFLD (1483 European cases 17,781 controls), ALD (2513 332,951 hepatitis risk (1971 340,528 controls). The main...
Pulmonary artery hypertension (PAH) is characterized by vascular remodeling, high pulmonary blood pressure, and right ventricular hypertrophy. Oxidative stress, inflammation remodeling are important components in PAH. Ellagic acid (EA) a phenolic compound with anti-oxidative, anti-inflammatory, anti-proliferative properties. This study aimed to investigate whether EA could prevent the development of monocrotaline (MCT)-induced PAH rats.Male Sprague-Dawley rats received (30 50mg/kg/day) or...
Monocytes or macrophages have been assessed as potential therapeutics to ameliorate myocardial ischemic diseases, but the results controversial. As regulatory macrophages, M2b could enhanced protective effects. We tested hypothesis that transplantation of ischemia/reperfusion (I/R) injury. The mechanisms involved in it were investigated.M2b polarized by lipopolysaccharide (LPS) and immune complex (IC) from bone marrow-derived (BMDMs) C57BL/6 mice. They identified based on surface marker...
Conditional graphic layout generation, which generates realistic layouts according to user constraints, is a challenging task that has not been well-studied yet. First, there limited discussion about how handle diverse constraints flexibly and uniformly. Second, make the conform existing work often sacrifices generation quality significantly. In this work, we propose LayoutFormer++ tackle above problems. constraint serialization scheme, represents different as sequences of tokens with...
Macrophages play an important role in the development of cardiac fibrosis. However, roles different macrophage subtypes fibroblast (CF) activation and fibrosis are unknown.
Whether the preoperative anemia affects prognosis and therapeutic choice between coronary artery bypass grafting (CABG) or medical therapy alone in patients with ischemic cardiomyopathy (ICM) remains unclear. We assess influence of on long-term outcomes ICM treated without CABG. Patients hemoglobin were included from Surgical Treatment Ischemic Heart Failure (STICH) trial. The primary outcome was all-cause mortality. A total 1,209 enrolled, 320 (26.5%) anemia, 889 (73.5%) anemia. median...
To evaluate the short-term clinical efficacy of external fixation and internal with steel plate in treatment unstable distal radius fractures (AO-23C type), based on principles Chinese osteosynthesis (CO). Forty-eight patients between January 2022 February 2023 were retrospectively analyzed divided into CO group group. consisted 25 patients, including 7 males 18 females, aged from 37 to 56 years old an average ( 52.6±11.3) old. Among them, there traffic accidents falls, resulting a total...
Structural changes of the left and right atria associated with atrial fibrillation (AF) in mitral stenosis (MS) patients are well known, alterations microRNA (miRNA) expression profiles have also been investigated. However, miRNA still require delineation. This study evaluated tissues from MS AF relative to those normal sinus rhythm (NSR). Sample appendages were obtained 12 (6 AF) during valve replacement surgery. From these tissues, created analyzed using a human microarray. Results...
As an effective anticancer drug, the clinical limitation of doxorubicin (Dox) is time- and dose-dependent cardiotoxicity. Yes-associated protein 1 (YAP1) interacts with transcription factor TEA domain (TEAD1) plays important role in cell proliferation survival. However, YAP1 Dox-induced cardiomyopathy has not been reported. In this study, expression was reduced human failing hearts dilated vivo vitro cardiotoxic model. Ectopic Yap1 significantly blocked cardiomyocytes apoptosis TEAD1...
Objective Doxorubicin (DOX) is an anthracycline antibiotic which widely used for the treatment of various cancers, while dose-related cardiotoxicity limits its potential therapeutic application. The underlying mechanism DOX induced complex and remains elusive. Our previous studies have shown that M2b macrophage plays important role in reducing inflammation due to ischemic reperfusion injury myocardium. purpose this study was investigate protective macrophages cardiotoxicity. Methods In vivo,...
The atrial fibrillation (AF) associated microRNAs (miRNAs) were found in the right atrium (RA) and left (LA) from patients with rheumatic mitral valve disease (RMVD). However, most studies only focus on RA; potential differences of AF-associated miRNAs between RA LA are still unknown. aim this study was to perform miRNA expression profiles analysis compare appendages (RAA) (LAA) RMVD patients.Samples tissues RAA LAA obtained 18 (10 AF) during replacement surgery. From these tissues, created...
Cardiac fibrosis is a significant global health problem with limited treatment choices. Although previous studies have shown that imatinib (IMA) inhibited cardiac fibrosis, the anti-fibrotic mechanisms not been clearly uncovered. The aim of this study to evaluate whether IMA attenuates by inhibiting platelet-derived growth factor receptors (PDGFR) on isoproterenol (ISO)-induced mice. Adult male C57BL/6 mice were treated vehicle or ISO ± for one week. After echocardiography examination,...
Therapeutic lymphangiogenesis is a new treatment for cardiovascular diseases. Our previous study showed M2b macrophages can alleviate myocardial ischaemia/reperfusion injury (MI/RI). However, the relation between and not clear.To investigate effects of on after MI/RI.Forty male Sprague-Dawley (SD) rats were randomized into Sham operation group (control, n = 8), MI/RI (n 16) macrophage transplantation 16). (1 × 106) in 100 μL normal saline or same volume vehicle was injected cardiac ischaemic...
Background The early mortality after surgery for infective endocarditis is high. Although risk models help identify patients at high risk, most current scoring systems are inaccurate or inconvenient. objective of this study was to construct an accurate and easy‐to‐use prediction model endocarditis. Methods Results A total 476 consecutive with who underwent 2 centers were included. development cohort consisted 276 patients. Eight variables selected from 89 potential predictors as input the...
Heart rate variability (HRV) is the most frequently used noninvasive diagnostic method in assessment of cardiac autonomic control. The clinical relevance HRV, especially nonlinear HRV CPB patients has not been well studied. Short brief myocardial ischemia reported to influence HRV. We therefore hypothesis that protective mechanism ischemic preconditioning (IP) may involve regulation.Eighty-six CABG were randomized into a control and an IP group. received two periods 2-min followed by 3-min...