A5074234171- Pulmonary Hypertension Research and Treatments
- Circular RNAs in diseases
- Cardiac Fibrosis and Remodeling
- Genomics, phytochemicals, and oxidative stress
- Mitochondrial Function and Pathology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mechanical Circulatory Support Devices
- Cancer therapeutics and mechanisms
- Oil and Gas Production Techniques
- Cancer, Lipids, and Metabolism
- Signaling Pathways in Disease
- Cholesterol and Lipid Metabolism
- Cancer, Hypoxia, and Metabolism
- Cardiac Valve Diseases and Treatments
- Cardiac Ischemia and Reperfusion
- Nitric Oxide and Endothelin Effects
- Macrophage Migration Inhibitory Factor
- Synthesis and biological activity
- Hydraulic and Pneumatic Systems
- High Altitude and Hypoxia
- Agriculture and Farm Safety
- Infective Endocarditis Diagnosis and Management
- Heart Failure Treatment and Management
- Orthopedic Infections and Treatments
- Ferroptosis and cancer prognosis
Central South University
2024-2025
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Sun Yat-sen University
2021-2024
Qinghai Red Cross Hospital
2024
Changsha Medical University
2024
Second Xiangya Hospital of Central South University
2024
Xiangya Hospital Central South University
2024
Qinghai Provincial Peoples Hospital
2021
<title>Abstract</title> <bold>Background:</bold>Over 80 million people reside above 2,500 meters, where hypobaric hypoxia elevates the risk of hypoxic pulmonary hypertension (HPH). In Qinghai, China (>3,000 m), over 5 face a high HPH burden amid scarce medical resources. <bold>Objective: </bold>To assess factors and clinical correlates severity mortality in high-altitude residents using echocardiography. <bold>Methods: </bold>This retrospective study included 627 patients diagnosed with...
Background The early mortality after surgery for infective endocarditis is high. Although risk models help identify patients at high risk, most current scoring systems are inaccurate or inconvenient. objective of this study was to construct an accurate and easy‐to‐use prediction model endocarditis. Methods Results A total 476 consecutive with who underwent 2 centers were included. development cohort consisted 276 patients. Eight variables selected from 89 potential predictors as input the...
Sodium-glucose cotransporter-2 (SGLT2) inhibitors, a novel class of hypoglycemic drugs, show excellent cardiovascular benefits, and have further improved heart failure outcomes, significantly reducing all-cause mortality irrespective diabetes status. However, the efficacy SGLT2 inhibitors in pulmonary arterial hypertension (PAH) right ventricular (RV) dysfunction remains unknown. This study aimed to evaluate effects dapagliflozin rats with PAH RV dysfunction. was induced by monocrotaline...
Introduction Current targeted pulmonary arterial hypertension (PAH) therapies have improved lung hemodynamics, cardiac function, and quality of life; however, none these reversed the ongoing remodeling blood vessels. Considering notopterol, a linear furocoumarin extracted from root traditional Chinese medicine Qiang-Huo ( Notopterygium incisum ), had shown antiproliferative anti-inflammatory properties in previous studies, we hypothesized that it could play role ameliorating PAH. Methods In...
Cardiac fibrosis is thought to be the hallmark of pathological hypertrophic remodeling, which myofibroblast transdifferentiation key cell biological event. However, there still no specific and effective therapeutic agent approved for cardiac fibrosis. To investigate effects belumosudil, first ρ-associated kinase-2 (ROCK2)-specific inhibitor, on hypertrophy, fibrosis, dysfunction induced by pressure overload, transverse aortic constriction (TAC) or sham operation was carried out wild-type...
Pulmonary arterial hypertension is a progressive angio-proliferative disease associated with high morbidity and mortality rates. Although the histopathology of pulmonary well described, its therapeutic option remains unsatisfactory. This study investigated effect celastrol treatment on right ventricular dysfunction, remodeling, vascular remodeling in rats as possible mechanisms.Pulmonary was induced male Sprague-Dawley by single subcutaneously injection monocrotaline. After daily delivery (1...
This study investigated the effects of hydroxycitric acid tripotassium hydrate on right ventricular function, myocardial and pulmonary vascular remodeling in rats with hypertension, possible mechanisms. Methods: Pulmonary hypertension was induced male Sprague-Dawley by a single subcutaneous injection monocrotaline or hypoxic chamber. In vivo, inflammatory cytokine (including TNF-α, IL-1β, IL-6, TGF-β, level SOD) expression, superoxide dismutase hydrogen peroxide levels, p-IκBα p65...
Non-small cell lung cancer (NSCLC), the most prevalent subtype, presents significant treatment challenges. Cisplatin (CP)-based regimens are central to of multiple solid tumors, but its use is restricted due dose-related renal toxicity. We previously found that fluorofenidone {1-[3-fluorophenyl]-5-methyl-2-[(1H)]-pyridone (AKF-PD)} effectively reverses CP-induced acute kidney injury (AKI). However, it remains unclear whether AKF-PD can synergistically ameliorate NSCLC when used together with...
Globally, non-small cell lung cancer (NSCLC) is the most fatal form of malignancy. Numerous studies have shown that people living at high altitudes are a higher risk for cancer. Hypoxia one important features in altitude area. Compared with normal cells, cells more adapted to hypoxia atmosphere. However, altitudes, hypoxic conditions also accompanied by other altered environmental conditions. To identify single influence hypoxia, we performed second-generation sequencing gene expression...
Background: Vitamins, and their metabolic processes play essential regulatory roles in controlling proliferation, differentiation, growth carcinogenesis. However, the role of vitamin metabolism lung adenocarcinoma (LUAD) has rarely been reported. Here, we established a novel prognostic model based on metabolism-related genes LUAD. Methods: In this research, aimed to identify associated with differentially expressed (DEGs) LUAD utilizing The Cancer Genome Atlas (TCGA)-LUAD, GSE68465 GSE72094...
Pulmonary hypertension (PH) is a life-threatening condition characterized by pulmonary vascular remodeling and endothelial dysfunction. Current therapies primarily target vasoactive imbalances but often fail to address adverse remodeling. Long non-coding RNA (lncRNA), which are key regulators of various cellular processes, remain underexplored in the context PH. To investigate role lncRNA PH, we performed comprehensive analysis using Weighted Gene Co-expression Network Analysis (WGCNA) on...
Abstract Normally in pump-storage power plant, spherical valve is installed the terminal of penstock. Spherical used to block water flow or involving regulation guarantee. The stability great importance for safe operation plant and unit. In this literature, two kinds implementation hydrodynamic closure method were discussed, comparisons methods made. On emphasis safety, shut-down unit was employed case For data achieved with rated load, characteristic analysis time domain spectrum frequency...
Abstract PurposePulmonary arterial hypertension (PAH) is a progressive angio-proliferative disease with high morbidity and mortality. Although the histopathology well described, its therapeutic effect still unsatisfactory. This study investigated treatment of celastrol on PAH rats right ventricular (RV) dysfunction, RV remodeling pulmonary vascular possible mechanisms.MethodsPAH in was induced by monocrotaline (MCT) single subcutaneously injection. After daily delivery Celastrol (1mg/kg) or...
Abstract Background: Pulmonary arterial hypertension (PAH) is a progressive angio-proliferative disease associated with high morbidity and mortality rates. Although the histopathology of PAH well described, its therapeutic option remains unsatisfactory. This study investigated effect celastrol treatment on right ventricular (RV) dysfunction, RV remodeling pulmonary vascular in rats as possible mechanisms. Methods: was induced by single subcutaneously injection monocrotaline (MCT). After...