A5069403604- Heat Transfer and Optimization
- Monoclonal and Polyclonal Antibodies Research
- Refrigeration and Air Conditioning Technologies
- Biosensors and Analytical Detection
- Metal Alloys Wear and Properties
- HER2/EGFR in Cancer Research
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Advanced biosensing and bioanalysis techniques
- Welding Techniques and Residual Stresses
- RNA Interference and Gene Delivery
- Advanced materials and composites
- Natural product bioactivities and synthesis
- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Aluminum Alloys Composites Properties
- Advanced Welding Techniques Analysis
- Advanced Cellulose Research Studies
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Advanced Sensor and Energy Harvesting Materials
- Phase Equilibria and Thermodynamics
- Fuel Cells and Related Materials
- Bacteriophages and microbial interactions
- Rocket and propulsion systems research
- DNA and Nucleic Acid Chemistry
Shantou University
2024-2025
Hunan Academy of Traditional Chinese Medicine
2024
Hefei University of Technology
2024
Fujian Medical University
2023
Xi'an Jiaotong University
2015-2022
Novartis (China)
2020
Jiangxi Academy of Sciences
2003-2019
Shenzhen Bioeasy Biotechnology (China)
2012
Wuhan University
2006
Shanghai Liangyou (China)
2004
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has become a serious burden on global public health. Although therapeutic drugs against COVID‐19 have been used in many countries, their efficacy is still limited. We here reported nanobody (Nb) phage display libraries derived from four camels immunized with the SARS‐CoV‐2 spike receptor‐binding domain (RBD), which 381 Nbs were identified to recognize SARS‐CoV‐2‐RBD. Furthermore, seven shown block interaction of human...
BackgroundKN026 is a novel human epidermal growth factor receptor 2 (HER2)-targeted bispecific antibody that binds two distinct domains of HER2. We report the safety and efficacy results phase trial in patients with advanced HER2-expressing gastric or gastroesophageal junction cancer who failed from at least one prior line standard treatment.Material methodsIn this open-label, multicentre, trial, eligible were enrolled high-level HER2 cohort low-level assigned to receive KN026 10 mg/kg (once...
Impact of crowding: Molecular crowding with poly(ethylene glycol) (PEG) induces the formation a G-quadruplex structure in guanine-rich strand telomeric DNA at K+-ion concentration that is unable to induce alone. The picture shows folding and unfolding DNA, revealed by fluorescence resonance energy transfer (FRET), efficiency which inversely dependent on distance between donor (D) acceptor (A).
Printed circuit heat exchanger (PCHE) is a promising candidate of coolers used for SCO2 Brayton cycle. The thermal-hydraulic performance in PCHE depends on the structure as well operating conditions due to its dramatic variation thermal physical properties near pseudo-critical point. This work experimentally investigated characteristics zigzag-channel PCHEs between and water at pressures that ranged from 8.0 11.0 MPa. Results showed increasing flow rate might affect more pronouncedly...
Abstract The outbreak of COVID-19 has emerged as a global pandemic. unprecedented scale and severity call for rapid development effective prophylactics or therapeutics. We here reported Nanobody (Nb) phage display libraries derived from four camels immunized with the SARS-CoV-2 spike receptor-binding domain (RBD), which 381 Nbs were identified to recognize SARS-CoV-2-RBD. Furthermore, seven shown block interaction human angiotensin converting enzyme 2 (ACE2) SARS-CoV-2-RBD-variants,...
3621 Background: Besides breast cancer (BC) and gastric cancer, HER2 is also widely expressed in other solid tumors, such as colorectal (CRC), NSCLC, gallbladder (GBC), renal pelvis (RPC), pancreatic ductal adenocarcinoma (PDAC), etc. The reports of immunotherapy combined with HER2-targeted therapy are limited. KN026 a novel bispecific antibody that simultaneously binds to two distinct epitopes. KN046 blocks both PD-L1 interaction PD-1 CTLA-4 CD80/CD86. Methods: KN026-203 study (NCT04521179)...
Background: Vitamins, and their metabolic processes play essential regulatory roles in controlling proliferation, differentiation, growth carcinogenesis. However, the role of vitamin metabolism lung adenocarcinoma (LUAD) has rarely been reported. Here, we established a novel prognostic model based on metabolism-related genes LUAD. Methods: In this research, aimed to identify associated with differentially expressed (DEGs) LUAD utilizing The Cancer Genome Atlas (TCGA)-LUAD, GSE68465 GSE72094...
Superhydrophobic surfaces have been used in various fields of engineering due to their resistance corrosion and fouling ability control fluid movement. Traditionally, superhydrophobic are fabricated via chemical methods changing the surface energy or mechanical controlling topology. Many conventional use a top-to-bottom scheme topolopy. Here, we develop novel fabrication method substrates using bottom-to-top polymer OSTE, which is prototyping material developed for microchips its superior...
Verhalten in der Masse: Räumliche Beengung durch Polyethylenglycol (PEG) induziert im Guanin-reichen Strang telomerer DNA die Bildung einer G-Quadruplex-Struktur bei K+-Konzentration, für sich alleine keine G-Quadruplex-Bildung auslöst. Das Falten und Entfalten von (siehe Bild) ist resonanten Fluoreszenzenergietransfer (FRET) nachweisbar, dessen Effizienz invers vom Abstand zwischen Donor- (D) Acceptoreinheiten (A) abhängt.