A5031677577- Nerve injury and regeneration
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Psoriasis: Treatment and Pathogenesis
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Surgical Sutures and Adhesives
- T-cell and B-cell Immunology
- Pancreatic function and diabetes
- Immunotherapy and Immune Responses
- Nanocomposite Films for Food Packaging
- IL-33, ST2, and ILC Pathways
- Diabetes Treatment and Management
- Silk-based biomaterials and applications
- Pediatric Pain Management Techniques
- Electrohydrodynamics and Fluid Dynamics
- Photodynamic Therapy Research Studies
- Whipple's Disease and Interleukins
- Inflammasome and immune disorders
- Advanced Cellulose Research Studies
- Erythropoietin and Anemia Treatment
- Magnetic and Electromagnetic Effects
- Nerve Injury and Rehabilitation
Wuhan University
2012-2024
Wuhan Donghu University
2024
Sichuan University of Science and Engineering
2023
University of Louisville
2017-2020
Wuchang University of Technology
2018
Peking University
2009
Jiangsu Province Blood Center
2005
Macrophages have been linked to tumor initiation, progression, metastasis, and treatment resistance. However, the transcriptional regulation of macrophages driving protumor function remains elusive. Here, we demonstrate that transcription factor c-Maf is a critical controller for immunosuppressive macrophage polarization in cancer. controls many M2-related genes has direct binding sites within conserved noncoding sequence Csf-1r gene promotes M2-like macrophage–mediated T cell suppression...
Interleukin-17F (IL-17F), produced by Th17 cells and other immune cells, is a member of IL-17 cytokine family with highest homology to IL-17A. IL-17F has been shown have multiple functions in inflammatory responses. While IL-17A plays important roles cancer development, the function tumorigenesis not yet elucidated. In current study, we found that expressed normal human colonic epithelial but this expression greatly decreased colon tissues. To examine cancer, used over-expressing cell lines...
Peripheral nerve regeneration requires stepwise and well-organized establishment of microenvironment. Since local delivery VEGF-A in peripheral repair is expected to promote angiogenesis the microenvironment Schwann cells (SCs) play critical role repair, combination VEGF may lead efficient regeneration. overexpressing were established loaded into inner wall hydroxyethyl cellulose/soy protein isolate/polyaniline sponge (HSPS) conduits. When HSPS mechanically distorted, it still has high...
Peripheral nerve regeneration and functional recovery remain major challenges in clinical practice. Nerve guidance conduits (NGCs) which can regulate the regenerative microenvironment are beneficial for peripheral repair. Platelet-rich plasma (PRP) secrete multiple growth factors to microenvironment. However, current administration methods of PRP rapidly activated followed by burst release factors, causing low therapeutic efficiency vivo. To overcome these disadvantages, a composite conduit...
β-Glucans have been shown to reduce the risk of obesity and diabetes. However, they often contain diverse polysaccharides other ingredients, leading elusive experimental data mechanisms. In this study, a pure β-glucan was obtained from crude Baker's yeast for investigating its effect on metabolic disorders in high-fat diet induced obese (DIO)/type 2 diabetic (T2D) mice underlying mechanism.The Fourier transform infrared spectroscopy nuclear magnetic resonance indicated that (BYGlc) linear...
Dendritic cells (DCs) are important in tumor immunology. Identifying DC subset markers the peripheral blood, which informative for gastric cancer stages, is not only useful prognosis but may also provide mechanistic insights into processes facilitating therapy. The present study investigated plasmacytoid dendritic (pDCs) and myeloid CD1c+ (mDC1s) blood of patients with healthy controls using flow cytometry. Using staining analysis, were identified to have substantially higher numbers pDCs...
Repair and regeneration of peripheral nerve defect by engineered conduits have greatly advanced in the past decades while still facing great challenges.In this work, we fabricated a new highly oriented poly(L-lactic acid) (PLLA)/soy protein isolate (SPI) nanofibrous conduit (HO-PSNC) for regeneration.Firstly, observed that SPI could efficiently modify PLLA electrospinning PLLA/SPI nanofibers with enhanced physical biological properties. Incorporation decreased fiber diameter ductility films...
Peripheral nerve injury is a common clinical neurological disease. In our previous study, highly oriented poly (L-lactic acid) (PLLA)/soy protein isolate (SPI) nanofiber conduits were constructed and exhibited certain repair capacity for peripheral injury. order to further improve their repairing efficiency, the bone marrow mesenchymal stem cells (BMSCs) overexpressing brain derived neurotrophic factor (BDNF) glial cell line-derived (GDNF) introduced into as seed then used 10-mm sciatic...
The objective of this work was to develop nerve guidance conduits from natural polymers, cellulose and soy protein isolate (SPI), by evaluating the effects cellulose/SPI film-based conduit (CSFC) sponge-based (CSSC) on regeneration defects in rats. CSFC CSSC with same chemical components were fabricated SPI. Effects defective comparatively investigated rats a 10 mm long gap sciatic nerve. outcomes peripheral repair evaluated combination electrophysiological assessment, Fluoro-Gold retrograde...
The combination of anti-angiogenic treatment and immunotherapy presents a promising strategy against colon cancer. Interleukin-17F (IL-17F) emerges as critical immune cell cytokine expressed in colonic epithelial cells, demonstrating potential inhibiting angiogenesis. In order to clarify the roles IL-17F cancer microenvironment elucidate its mechanism, we established mouse carcinoma line CT26 overexpressing transplanted it subcutaneously into syngeneic BALB/c mice. We also analyzed induced...
Summary Interleukin‐17 ( IL ‐17) is a cytokine with critical functions in multiple autoimmune diseases. However, its roles type I diabetes and the underlying mechanisms remain to be fully elucidated. In current study, we investigated impact of ‐17 deficiency on streptozotocin STZ ) ‐induced diabetes. Il‐17 −/− mice exhibited attenuated hyperglycaemia insulitis after treatment compared control mice. The had fewer CD 8 + cells infiltrating pancreas than wild‐type controls injection. Wild‐type...
The treatment and repair of serious peripheral nerve injuries remain challenging in the clinical practice, while application multifunctional guidance conduits (NGCs) based on naturally derived polymers has attracted much attention recent years because their excellent physicochemical properties biological characteristics. Flammulina velutipes (Curt. ex FV) is a popular edible mushroom characterized by hollow tubular structures, antibacterial activities, high nutritional properties. In this...
Soy protein isolate (SPI) is green, high-yield natural plant protein, which widely applied in industry (packing material and adhesives) tissue engineering. It meaningful to improve the antibacterial property of soy fabricate versatile safe products meet people's requirements. In this study, quaternized (QSPI) was synthesized by reaction between 2,3-epoxypropyltrimethylammonium chloride (EPTMAC) SPI. The positive charged (17.8 ± 0.23 mV) quaternary ammonium groups endow QSPI with superior...
Innate γδ T cells play critical roles in mucosal immunity such as regulating intestinal epithelial homeostasis. In addition, are significantly increased the inflamed mucosa of patients with ulcerative colitis. However, a heterogeneous population. IL-17-producing versus IFNγ-producing differential different disease settings. Therefore, dissecting exact role subsets colitis is essential for understanding immunopathogenesis. current study, we found that TCR δ-deficient mice had more severe...
Metastasis is the leading cause of death in breast cancer patients. Recent evidence suggests that inflammation-related cytokine tumor necrosis factor-alpha (TNF-α) implicated invasion and metastasis, but mechanism its involvement remains elusive. In this study, we employed MCF-7 cells as an experimental model to demonstrate TNF-α inhibits cell adhesion proliferation through hypoxia inducible factor-1alpha (HIF-1α) mediated suppression vasodilator-stimulated phosphoprotein (VASP). We observed...
Regenerated cellulose/SPI composite beads fabricated by a high-voltage electrostatic technique exhibited good cytocompatibility.
A series of composite films were prepared from glycerol-plasticized starch and zein by intensive mixing hot press. The structure physical properties the starch/zein (SZ) characterized scanning electron microscope (S