A5054322049- HIV Research and Treatment
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Immune cells in cancer
- RNA Research and Splicing
- Prion Diseases and Protein Misfolding
- Cancer-related Molecular Pathways
- Neurogenesis and neuroplasticity mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Ocular Oncology and Treatments
- Antifungal resistance and susceptibility
- Immune Cell Function and Interaction
- Oral Health Pathology and Treatment
- Cancer Research and Treatments
- Hepatitis C virus research
- Photoreceptor and optogenetics research
- Retinal Diseases and Treatments
- Protease and Inhibitor Mechanisms
Kunming Medical University
2021-2025
University of North Texas Health Science Center
2014-2024
University of North Texas
2014-2024
Tianjin Medical University General Hospital
2022-2024
Huazhong University of Science and Technology
2023
Tongji Hospital
2023
Stomatology Hospital
2020-2021
Smith-Kettlewell Eye Research Institute
2017
Harbin Medical University
2015
Indiana University School of Medicine
2009-2014
Endothelial-monocyte activating polypeptide II (EMAP II) was initially identified in the supernatant of murine methylcholanthrene A-induced fibrosarcomas (Meth A) by its capacity to activate host effector cells (Kao, J., Ryan, Brett, Chen, Shen, H., Fan, Y-G., Godman, G., Familletti, P., Wang, F., Pan, Y-C., Stern, D., and Clauss, M. (1992) J. Biol. Chem. 267, 20239-20247). Based on NH2-terminal protein sequence, a full-length cDNA has been cloned which indicates that precursor EMAP is...
An important means by which tumor cells influence the vasculature is through production of soluble mediators altering vascular properties. A approximately 22-kDa polypeptide was purified to homogeneity from conditioned medium murine methylcholanthrene (meth A) fibrosarcoma ion-exchange chromatography and preparative sodium dodecyl sulfate-polyacryl-amide gel electrophoresis (SDS-PAGE), based on its ability induce tissue factor procoagulant activity in endothelial (ECs). The final product...
HIV-1 Tat is a major culprit for HIV/neuroAIDS. One of the consistent hallmarks HIV/neuroAIDS reactive astrocytes or astrocytosis, characterized by increased cytoplasmic accumulation intermediate filament glial fibrillary acidic protein (GFAP). We have shown that induces GFAP expression in and activation indispensable astrocyte-mediated neurotoxicity. However, underlying molecular mechanisms are not known. In this study, we showed led to formation aggregates induction unfolded response (UPR)...
Aims: Cellular response to hypoxia can include transition from respiration glycolysis via upregulation of glycolytic enzymes and transporters, as well mitophagy induction eliminate surplus mitochondria. Our purpose was evaluate the impact hypoxia-inducible factor-1α (HIF-1α) stabilization on mitochondrial homeostasis oxidative stress in a chronic model glaucoma. Results: Retina optic nerve (ON) were evaluated young aged DBA/2J (D2) glaucoma mice control strain, DBA/2-Gpnmb+. Hypoxic retinal...
Alterations in adult neurogenesis have been noted the brain of HIV-infected individuals and are likely linked to HIV-associated neurocognitive deficits, including those learning memory. But underlying molecular mechanisms not fully understood. In study, we took advantage doxycycline-inducible astrocyte-specific HIV-1 Tat transgenic mice (iTat) determined relationship between expression neurogenesis. astrocytes was associated with fewer neuron progenitor cells (NPCs), immature neurons, mature...
Abstract Spinal cord injury (SCI) seriously affects the health of humans and quality life, causing disabilities. Due to ever-increasing traffic cases natural disasters, such as earthquakes, incidence SCI increases every year, thus a huge economic burden society patients. The lack neurotrophic factors in area affected by presence inhibitory for axonal regeneration are important reasons that make spinal repair extremely difficult. Additionally, correct projection axons also plays an role. As...
Endothelial-monocyte-activating polypeptide II (EMAP II) is a novel mediator isolated from conditioned medium of methylcholanthrene A-induced tumor cells which modulates properties endothelial cells, mononuclear phagocytes (MPs), and polymorphonuclear leukocytes (PMNs) in vitro induces an acute inflammatory response vivo. A synthetic peptide comprising 15 residues the N-terminal region (residues 6-20) was shown to induce directional migration MPs PMNs, with half-maximal effect at...
HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Several recent studies including ours have demonstrated that can be transferred to neighboring cells and alters the function of these cells. However, how intercellular transfer occurs in dispute. In current study, we attempted address this issue using several complementary strategies, a panel exosomal markers, human CD4+ T lymphocyte cell line Jurkat commonly used 293T. First, showed was from Nef-expressing or...
HIV-1 Tat protein is an important pathogenic factor in HIV-1-associated neurological diseases. One hallmark of infection the central nervous system (CNS) astrocytosis, which characterized by elevated glial fibrillary acidic (GFAP) expression astrocytes. We have shown that activates GFAP astrocytes [Zhou et al., (2004) Mol Cell Neurosci 27:296-305] and regulator neurotoxicity [Zou (2007) Am J Pathol 171:1293-1935]. However, underlying mechanisms for Tat-mediated up-regulation are not...
HIV-1 infection enhances HCV replication and as a consequence accelerates HCV-mediated hepatocellular carcinoma (HCC). However, the precise molecular mechanism by which this takes place is currently unknown. Our data showed that infectious failed to replicate in human hepatocytic cell lines. No discernible virus was observed, even when lines transfected with proviral DNA were co-cultured Jurkat T cells, indicating problem of liver deterioration co-infected patient not due hepatocytes...
Hypoxia often occurs under various physiological and pathophysiological conditions, including solid tumors; it is linked to malignant transformation, metastatic progression, treatment failure or resistance. Tip110 protein plays important roles in several known processes, cancers. Thus, the present study we investigated regulation of expression hypoxia. led degradation through ubiquitin-proteasome system. Under hypoxia, stabilized p53, which return destabilized Tip110. In addition, regulated...
Human immunodeficiency virus type 1 (HIV-1) Tat protein is a major pathogenic factor in HIV-associated neurological diseases; it exhibits direct neurotoxicity and indirect astrocyte-mediated neurotoxicity. We have shown that alone capable of activating glial fibrillary acidic (GFAP) expression inducing astrocytosis involving sequential activation early growth response (Egr-1) p300. In this study, we determined the roles signal transducer activator transcription 3 (STAT3) Tat-induced GFAP...
Patients with eosinophilic asthma react well to conventional treatment of while individualized therapy for non-eosinophilic endotypes have yet be developed. Dysregulated sphingosine metabolites are associated the pathophysiology different their receptors involved. However, whether sphingosine-1-phosphate receptor 4 (S1PR4) contributes disease progression remains underappreciated. In this study, we demonstrated that metabolism was disturbed in it could not used distinguish between asthma....
Therapeutic successes following treatment of murine tumors with tumor necrosis factor-α (TNF) have not been easily applied to clinical oncology because the concentrations TNF required in humans induces systemic toxicity. This has led us identify mediators which could sensitize effects TNF, permitting administration lower doses and possible realization therapeutic potential this cytokine. Our study reports ability a novel cytokine, endothelial-monocyte-activating polypeptide II (EMAP II),...