A5013973785- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Ocular Surface and Contact Lens
- Angiogenesis and VEGF in Cancer
- Retinal Imaging and Analysis
- Ophthalmology and Visual Impairment Studies
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- RNA Interference and Gene Delivery
- Ocular Infections and Treatments
- Retinal and Macular Surgery
- Advanced Drug Delivery Systems
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebral Venous Sinus Thrombosis
- Lymphatic System and Diseases
- interferon and immune responses
- RNA regulation and disease
- Nanoparticle-Based Drug Delivery
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Hypoxia, and Metabolism
Creative Commons
2023
Pacific Northwest University of Health Sciences
2023
Western University of Health Sciences
2023
University of Oregon
2021-2022
St. Vincent's Hospital
2012-2022
Oregon Center For Applied Science (United States)
2022
Impact Technology Development (United States)
2022
University of Utah
2011-2020
Loma Linda University
2020
Eye Institute of Utah
2010-2020
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized nations, affecting 30–50 million people worldwide. The earliest clinical hallmark AMD presence drusen, extracellular deposits that accumulate beneath retinal pigmented epithelium. Although drusen nearly always precede and increase risk choroidal neovascularization (CNV), late vision-threatening stage AMD, it unknown whether contribute to development CNV. Both patients with a recently...
To investigate the role of macrophages in development laser-induced choroidal neovascularization (CNV) by selective depletion with liposomal clodronate (Cl(2)MDP-LIP).Laser photocoagulation was used to induce CNV wild-type C57BL/6J mice. Animals were treated intravenous (IV) and/or subconjunctival (SC) Cl(2)MDP-LIP or PBS-LIP at following time points: 2 days before, immediately after, before and after laser injury. responses compared on basis en masse volumetric measurements fluorescein...
There is strong evidence that overproduction of soluble fms-like tyrosine kinase-1 (sFLT1) in the placenta a major cause vascular dysfunction preeclampsia through sFLT1-dependent antagonism VEGF. However, placental sFLT1 upregulation not known. Here we demonstrated women with preeclampsia, upregulated trophoblasts, while VEGF adjacent maternal decidual cells. In response to VEGF, expression sFlt1 mRNA, but full-length Flt1 increased cultured murine trophoblast stem We developed method for...
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly. Wet AMD includes typical choroidal neovascularization (CNV) and polypoidal vasculopathy (PCV). The etiology pathogenesis CNV PCV are not well understood. Genome-wide association studies have linked a multifunctional serine protease, HTRA1, to AMD. However, precise role HTRA1 remains elusive. By transgenically expressing human mouse retinal pigment epithelium, we showed that increased induced...
Neovascularization in response to tissue injury consists of the dual invasion blood (hemangiogenesis) and lymphatic (lymphangiogenesis) vessels. We reported recently that 21-nt or longer small interfering RNAs (siRNAs) can suppress hemangiogenesis mouse models choroidal neovascularization dermal wound healing independently RNA interference by directly activating Toll-like receptor 3 (TLR3), a double-stranded immune receptor, on cell surface endothelial cells. Here, we show nontargeted siRNA...
Microglia serve key homeostatic roles, and respond to neuronal perturbation decline with a high spatiotemporal resolution. The course of all chronic CNS pathologies is thus paralleled by local microgliosis microglia activation, which begin at early stages the disease. However, possibility using live monitoring during disease progression predict severity neurodegeneration has not been explored. Because retina allows tracking fluorescent in their intact niche, here we investigated changes...
Abstract An intractable challenge in glaucoma treatment has been to identify druggable targets within the conventional aqueous humor outflow pathway, which is thought be regulated/dysregulated by elusive mechanosensitive protein(s). Here, biochemical and functional analyses localized putative cation channel TRPV4 plasma membrane of primary immortalized human TM (hTM) cells, mouse tissue. Selective agonists substrate stretch evoked TRPV4-dependent cation/Ca 2+ influx, thickening F-actin...
Rationale: The availability of therapeutics to treat pregnancy complications is severely lacking, mainly due the risk harm fetus. In placental malaria, Plasmodium falciparum-infected erythrocytes (IEs) accumulate in placenta by adhering chondroitin sulfate A (CSA) on surfaces trophoblasts. Based this principle, we have developed a method for targeted delivery payloads using synthetic CSA-binding peptide (plCSA-BP) derived from VAR2CSA, protein expressed IEs. Methods: biotinylated plCSA-BP...
Flagellin is the major structural protein of flagella Gram-negative bacteria and a potent trigger innate immune responses in number eukaryotic cells organisms. In this study, we sought to determine whether flagellin induces an inflammation response cultured human corneal epithelial (HCE) underlying mechanisms.Flagellin was purified from Pseudomonas aeruginosa (PA) strain PAO1 with ammonium sulfate gradient precipitation lipopolysaccharide preparation removed by ion exchange chromatography....
To investigate the role of leukocyte adhesion molecules CD18 and intercellular molecule (ICAM)-1 in development choroidal neovascularization (CNV).Laser photocoagulation was used to induce CNV wild-type C57BL/6J mice species-specific counterparts with targeted homozygous disruption or ICAM-1 gene. Expression after laser injury assessed by immunostaining. responses were compared on basis en masse volumetric measurements obtained confocal microscopy 2 weeks determination fluorescein...